Ageing changes the cellular basis of the "fight-or-flight" response in human adrenal chromaffin cells

Neurobiology of Aging

Volumn 23, Issue 2, 2002, Pages 287-293

  Elhamdani, Abdeladim ^a   Palfrey, Clive H ^b   Artalejo, Cristina R ^a  

^a WAYNE STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF CHICAGO   (United States)

Author keywords

Amperometry recording; Calcium channels; Catecholamine release; Dense core vesicles; Fight or flight; Human adrenal chromaffin cells; Stress

Indexed keywords

CALCIUM CHANNEL L TYPE; CALCIUM CHANNEL N TYPE; CALCIUM CHANNEL P TYPE; CATECHOLAMINE; NISOLDIPINE;

ADOLESCENT; ADULT; AGING; AMPEROMETRY; ANIMAL TISSUE; ARTICLE; CALCIUM CURRENT; CATECHOLAMINE RELEASE; CELL SECRETION; CHROMAFFIN CELL; CONTROLLED STUDY; FACILITATION; FEMALE; HUMAN; HUMAN TISSUE; MALE; NONHUMAN; NORMAL HUMAN; PRIORITY JOURNAL; STRESS;

ACTION POTENTIALS; ADOLESCENT; ADRENAL GLANDS; ADULT; AGGRESSION; AGING; CALCIUM CHANNELS; CELLS, CULTURED; CHROMAFFIN CELLS; ELECTROPHYSIOLOGY; FEMALE; HUMANS; KINETICS; MALE; MIDDLE AGED; PATCH-CLAMP TECHNIQUES;

EID: 0036170299     PISSN: 01974580     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0197-4580(01)00275-5     Document Type: Article

References (22)

1. Three types of Ca2+ channel trigger secretion with different efficacies in chromaffin cells
2. 2+ currents are found in bovine chromaffin cells: Facilitation is due to the recruitment of one type
3. Three types of bovine chromaffin cell Ca2+ channels: Facilitation increases the opening probability of a 27 pS channel
4. 2+ current facilitation in chromaffin cells
5. Ageing changes in voltage-gated calcium currents in hippocampal CA1 neurons
6. Delay in vesicle fusion revealed by electrochemical monitoring of single secretory events in adrenal chromaffin cells
7. Ageing is associated in the 344/N Fischer rat with decreased stress responsivity of central and peripheral catecholaminergic systems and impairment of the hypothalamic-pituitary-adrenal axis
8. Facilitation of Ca2+ current in excitable cells
9. Timing of dense-core vesicle exocytosis depends on the facilitation L-type Ca channel in adrenal chromaffin cells
10. 2+-dependent activator protein for secretion is critical for the fusion of dense-core vesicles with the membrane in calf adrenal chromaffin cells
11. Effects of ageing on epinephrine secretion and regional release of epinephrine from the human heart
12. Chromaffin cell action potentials and their possible role in adrenaline secretion from rat adrenal medulla
13. Calcium currents in aged rat dorsal root ganglion neurones
14. Stress, ageing, and memory. Involvement of peripheral catecholamines
15. Aged rats: Diminished sympathetic-adrenal medullary responses to acute stress
16. Regulation of peripheral catecholamine responses to acute stress in young adult and aged F-344 rats
17. Rapid exocytosis in single chromaffin cells recorded from mouse adrenal slices
18. Timing of synaptic transmission
19. Spatio-temporal resolution of exocytosis from individual cells
20. Temporally resolved catecholamine spikes correspond to single vesicle release from individual chromaffin cells