Protective effect of thiaton, an antispasmodic drug, against indomethacin-induced intestinal damage in rats

Japanese Journal of Pharmacology

Volumn 88, Issue 1, 2002, Pages 45-54

  Kunikata, Tomonori ^a   Miyazawa, Tohru ^a   Kanatsu, Kenji ^a   Kato, Shinichi ^a   Takeuchi, Koji ^a  

^a KYOTO PHARMACEUTICAL UNIVERSITY   (Japan)

Author keywords

Antispasmodic drug; Enterobacterial translocation; Indomethacin induced intestinal lesion; Intestinal motility; Thiaton

Indexed keywords

16,16 DIMETHYLPROSTAGLANDIN E2; ATROPINE; INDOMETACIN; MYELOPEROXIDASE; NITRIC OXIDE SYNTHASE; SPASMOLYTIC AGENT; TIQUIZIUM BROMIDE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BACTERIAL TRANSLOCATION; CONTROLLED STUDY; DIGESTIVE SYSTEM INFLAMMATION; DRUG EFFECT; ENZYME ACTIVITY; ENZYME INHIBITION; INTESTINE FLUID; INTESTINE INJURY; INTESTINE MOTILITY; INTESTINE MUCOSA; MALE; NONHUMAN; PROTECTION; RAT; SECRETION; SMALL INTESTINE DISEASE; SUPPLEMENTATION;

EID: 0036170056     PISSN: 00215198     EISSN: None     Source Type: Journal    
DOI: 10.1254/jjp.88.45     Document Type: Article

References (30)

1. Resistance of germ-free rats to indomethacin-induced intestinal inflammation
2. Indomethacin induced intestinal inflammation
3. Nonsteroidal anti-inflammatory drug-induced intestinal inflammation in humans
4. Temporal relationship between cyclooxygenase inhibition, as measured by prostacyclin biosynthesis, and the gastrointestinal damage induced by indomethacin in rat
5. Indomethacin-increased gastrointestinal lesions in relation to tissue concentration, food intake and bacterial invasion in the rat
6. 2
7. Mechanisms of acute and chronic intestinal inflammation induced by indomethacin
8. Inducible nitric oxide synthase and microvascular injury in the rat jejunum provoked by indomethacin
9. The induction of nitric oxide synthase and intestinal vascular permeability by endotoxin in the rat
10. Nitric oxide, superoxide radicals and mast cells in pathogenesis of indomethacin-induced small intestinal lesions in rats
11. Dual action of nitric oxide in pathogenesis of indomethacin-induced small intestinal ulceration in rats
12. E type prostaglandin inhibits indomethacin-induced small intestinal lesions through EP3 and EP4 receptors: A study using rats and knockout mice
13. Pharmacological studies on antispasmodics. I. Selectivity to antispasmodic activity of diarylmethylene-5-methyl-trans-quinolizidinium bromides
14. Pharmacological studies on antispasmodics. III. Antispasmodic activity of 3-(di-2-thienylmethylene)-5-methyl-trans-quinolizidinium bromide (HSR-902) on smooth organs and its organ selectivity
15. Cytoprotective activity of tiquizium bromide (HSR-902) and its mechanism
16. Studies on the affinity and selectivity of tiquizium bromide (HSR-902), a novel spasmolytic agent, for muscarinic receptors
17. Measurement of cutaneous inflammation: Estimation of neutrophil content with an enzyme marker
18. Differential distribution of nitric oxide synthase between cell fractions isolated from the rat gastric mucosa
19. Involvement of endogenous nitric oxide in the regulation of rat intestinal motility in vivo
20. Correlation of quantitative changes of gastric mucosal glycoproteins with aspirin-induced gastric damage in rats
21. Enteropooling assay: A test for diarrhea produced by prostaglandins
22. Oxygen free radicals and lipid peroxidation in the pathogenesis of gastric mucosal lesions induced by indomethacin in rats
23. The pathogenesis of ischemic gastroenterocolitis of the neonate: Selective gut mucosal ischemia in asphyxiated neonatal piglets
24. Microcirculatory disturbance in indomethacin-induced intestinal ulcer
25. Early histological features of small intestinal injury induced by indomethacin
26. Vascular anatomy defines sites of indomethacin induced jejunal ulceration along the mesenteric margin
27. Importance of gastric motility in the pathogenesis of indomethacin-induced gastric lesions in rats
28. Nitric oxide in gastrointestinal physiology and pathology
29. Increase in tumor necrosis factor-α production linked to the toxicity of indomethacin for the rat small intestine
30. Role of TNF-α and nitric oxide in the protective effect of tiquizium bromide on indomethacin-induced gastric mucosa injury in rats