trans-complementation rescue of cyclophilin A-deficient viruses reveals that the requirement for cyclophilin A in human immunodeficiency virus type 1 replication is independent of its isomerase activity

Journal of Virology

Volumn 76, Issue 5, 2002, Pages 2255-2262

  Saphire, Andrew C S ^a   Bobardt, Michael D ^a   Gallay, Philippe A ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLOPHILIN A; CYCLOSPORIN; GAG PROTEIN; ISOMERASE; VIRUS PROTEIN; VPR PROTEIN;

ARTICLE; CHIMERA; CONTROLLED STUDY; ENZYME ACTIVE SITE; ENZYME ACTIVITY; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN PROTEIN INTERACTION; VIRUS GENOME; VIRUS INFECTIVITY; VIRUS MUTANT; VIRUS REPLICATION;

CELL LINE; CYCLOPHILIN A; GENE PRODUCTS, VPR; GENETIC COMPLEMENTATION TEST; HELA CELLS; HIV INFECTIONS; HIV-1; HUMANS; ISOMERASES; MUTATION; RECOMBINANT FUSION PROTEINS; TRANSFECTION; VIRUS ASSEMBLY; VIRUS REPLICATION;

EID: 0036168738     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/jvi.76.5.2255-2262.2002     Document Type: Article

References (41)

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3. Cyclophilin A is required for an early step in the life cycle of human immunodeficiency virus type 1 before the initiation of reverse transcription
4. The hydrophobic pocket of cyclophilin is the binding site for the human immunodeficiency virus type 1 Gag polyprotein
5. Cyclophilin A regulates HIV-1 infectivity, as demonstrated by gene targeting in human T cells
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