Synthesis, structure investigations, and antimicrobial activity of selected s-trans-6-aryl-4-isopropyl-2-{2-[(E)-1-phenylalkylidene]-(E)-hydrazino}-1,4- dihydropyrimidine hydrochlorides

European Journal of Pharmaceutical Sciences

Volumn 15, Issue 1, 2002, Pages 49-61

  Gößnitzer, Edith ^a   Feierl, Gebhard ^a   Wagner, Ute ^a  

^a UNIVERSITY OF GRAZ   (Austria)

Author keywords

(E) 1 Phenylalkylideneaminoguanidines; Antimicrobial activity; NMR analyses; s trans 6 Aryl 4 isopropyl 2 2 (E) 1 phenylalkylidene (E) hydrazino 1,4 dihydropyrimidine hydrochlorides, synthesis and structure investigations

Indexed keywords

BACTERIOLOGY; CONDENSATION; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY;

RING CLOSURE REACTIONS;

ORGANIC COMPOUNDS;

1,4 DIHYDROPYRIDINE DERIVATIVE;

ANTIFUNGAL ACTIVITY; ANTIMICROBIAL ACTIVITY; ARTICLE; CANDIDA ALBICANS; DRUG EFFECT; DRUG RESEARCH; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; GRAM NEGATIVE BACTERIUM; GRAM POSITIVE BACTERIUM; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PRIORITY JOURNAL; STRUCTURE ANALYSIS;

ANTI-BACTERIAL AGENTS; ANTI-INFECTIVE AGENTS; ANTIFUNGAL AGENTS; CANDIDA ALBICANS; GRAM-NEGATIVE BACTERIA; GRAM-POSITIVE BACTERIA; GUANIDINES; HYDROCARBONS; METHANE; MICROBIAL SENSITIVITY TESTS; PYRIMIDINES;

EID: 0036166849     PISSN: 09280987     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0928-0987(01)00202-0     Document Type: Article

References (36)

1. Studies on methylglyoxal bis(guanylhydrazone) analogues II. Structural variations on methylglyoxal bis(guanylhydrazone)
2. Procedures and theoretical considerations for testing antimicrobial agents in agar media
3. Correlation of proton chemical shifts by two-dimensional Fourier transform NMR
4. 13C assignments from sensitivity-enhanced detection of heteronuclear multiple-bond connectivity by 2D multiple quantum NMR
5. Evaluation of the thiosemicarbazones of some aryl alkyl ketones and related compounds for anticonvulsant activities
6. 3-Cyclohexyl-2-(cyclohexylidenemethyl)-1,5-diaryl-1,5-pentanediones: Synthesis and reactions with methylamine and amidines
7. Unerwartete (2:1)- und (2:2)-kondensate aus aldehyden und alkanonen bzw. Cycloalkanonen: Synthese, strukturaufklärung mit nmr und biologische wirkungen
8. (2:1)-Kondensate aus α,β-ungesättigten ketonen und guanidin: Synthese, strukturanalyse mit NMR und pharmakologische wirkungen
9. 7-isomerase
10. Synthese und strukturaufklärung von pyrimidobenzimidazolen und kondensierten derivativen III. Decahydropyrimido-[1,2-a]benzimidazol-2-ole und octahydropyrimido[1,2-a]benzimidazole
11. Special reactions of α,β-unsaturated ketones, III. Structure and stereochemistry of perhydro-5a,11a-epoxydibenz[b,f]oxepin-4a-ol, a bridged Diels-Alder dimer of 2-methylenecyclohexanone
12. Guanylhydrazones of (hetero)aryl methyl ketones: Structure and reaction with acetic anhydride
13. 13C spectra to establish configurations of oximes
14. Azinyl and diazinyl hydrazones derived from aryl N-heteroaryl ketones: Synthesis and antiproliferative activity
15. Investigation of exchange processes by two-dimensional NMR spectroscopy
16. Pure absorption gradient enhanced heteronuclear single quantum correlation spectroscopy with improved sensitivity
17. Improved frequency selectivity in nuclear Overhauser effect difference spectroscopy
18. Chemotherapeutics XXXIV. Synthesis of some heterocyclic hydrazine compounds an their action on Tubercle bacilli
19. Cationic antiprotozoal drugs. Trypanocidal activity of 2-(4′-formylphenyl)imidazo[1,2-a]pyridinium guanylhydrazones and related derivatives of quaternary heteroaromatic compounds
20. Bis-cationic heteroaromatics as macrofilaricides: Synthesis of bis-amidine and bis-guanylhydrazone derivatives of substituted imidazo[1,2-a]pyridines
21. The perfume group I. Condensation capacity of isobutyraldehyde
22. Utilization of operational schemes for analog synthesis in drug design
23. A manual method for applying the Hansch approach to drug design
24. Über m-nitroguanazylmethan und verwandte körper
25. 2-Substituted 2-pyrimidinamines and dihydro-2-pyrimidinamines by reaction of phenylbutenones and monosubstituted guanidines
26. Synthese, reaktivität und pharmakologische bzw. biologische Wirkungen von teilhydrierten. Pyrimidinen und kondensierten derivaten
27. Über synthese, reaktivität und pharmakologische bzw. biologische Wirkungen von di- und tetrahydropyrimidinen
28. Synthese und pharmakologische wirkung von benzo[h]chinolinaminen
29. Synthesis and structure elucidation of pyrimidobenzimidazoles and fused derivatives II. Dodecahydro-benzimidazo[2,1-b]quinazolines and decahydrobenzimidazo[2,1-b]benzo[h]quinazolines
30. Substituted chalcones
31. Gradient selection in inverse heteronuclear correlation spectroscopy