Synthesis and biological activity of 5-alkyl-6-(alkylsulfanyl)- or 5-alkyl-6-(arylsulfanyl)pyrazine-2-carboxamides and corresponding thioamides

Farmaco

Volumn 57, Issue 1, 2002, Pages 71-78

  Krinková, Jana ^a   Doležal, Martin ^a   Hartl, Jiří ^a   Buchta, Vladimír ^a   Pour, Milan ^a  

^a Charles University in Prague Faculty of Pharmacy   (Czech Republic)

Author keywords

Antifungal evaluation; Antimycobacterial activity; Nucleophilic substitution; Pyrazines; Structure activity relationships

Indexed keywords

5 BUTYL 6 (BUTYLSULFANYL)PYRAZINE 2 CARBOXAMIDE; 5 BUTYL 6 (ETHYLSULFANYL)PYRAZINE 2 CARBOXAMIDE; 5 BUTYL 6 (METHYLSULFANYL)PYRAZINE 2 CARBOXAMIDE; 5 BUTYL 6 (PHENYLSULFANYL)PYRAZINE 2 CARBOTHIOAMIDE; 5 BUTYL 6 (PHENYLSULFANYL)PYRAZINE 2 CARBOXAMIDE; 5 BUTYL 6 (PROPYLSULFANYL)PYRAZINE 2 CARBOXAMIDE; 5 ISOBUTYL 6 (METHYLSULFANYL)PYRAZINE 2 CARBOXAMIDE; 5 ISOBUTYL 6 (PHENYLSULFANYL)PYRAZINE 2 CARBOXAMIDE; 5 ISOBUTYL 6 (PROPYLSULFANYL)PYRAZINE 2 CARBOXAMIDE; 5 PROPYL 6 (PROPYLSULFANYL)PYRAZINE 2 CARBOXAMIDE; 5 TERT BUTYL 6 (BUTYLSULFANYL)PYRAZINE 2 CARBOXAMIDE; 5 TERT BUTYL 6 (ETHYLSULFANYL)PYRAZINE 2 CARBOXAMIDE; 5 TERT BUTYL 6 (METHYLSULFANYL)PYRAZINE 2 CARBOXAMIDE; 5 TERT BUTYL 6 (PHENYLSULFANYL)PYRAZINE 2 CARBOXAMIDE; 5 TERT BUTYL 6 (PROPYLSULFANYL)PYRAZINE 2 CARBOXAMIDE; 6 (BUTYLSULFANYL) 5 ISOBUTYLPYRAZINE 2 CARBOXAMIDE; 6 (BUTYLSULFANYL) 5 PROPYLPYRAZINE 2 CARBOXAMIDE; 6 (ETHYLSULFANYL) 5 ISOBUTYLPYRAZINE 2 CARBOTHIOAMIDE; 6 (ETHYLSULFANYL) 5 ISOBUTYLPYRAZINE 2 CARBOXAMIDE; 6 (ETHYLSULFANYL) 5 PROPYLPYRAZINE 2 CARBOTHIOAMIDE; 6 (ETHYLSULFANYL) 5 PROPYLPYRAZINE 2 CARBOXAMIDE; 6 (METHYLSULFANYL) 5 PROPYLPYRAZINE 2 CARBOTHIOAMIDE; 6 (METHYLSULFANYL) 5 PROPYLPYRAZINE 2 CARBOXAMIDE; 6 (PHENYLSULFANYL) 5 PROPYLPYRAZINE 2 CARBOXAMIDE; AMIDE; UNCLASSIFIED DRUG;

ABSIDIA; ANTIBACTERIAL ACTIVITY; ANTIFUNGAL ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG SYNTHESIS; IN VITRO STUDY; LIPOPHILICITY; MOLECULAR WEIGHT; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; TRICHOPHYTON MENTAGROPHYTES;

ANTI-INFECTIVE AGENTS; ANTIFUNGAL AGENTS; MICROBIAL SENSITIVITY TESTS; PYRAZINES; STRUCTURE-ACTIVITY RELATIONSHIP; THIOAMIDES;

EID: 0036166412     PISSN: 0014827X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-827X(01)01156-9     Document Type: Article

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