Enhancement by cyclosporine A and tacrolimus of serotonin-induced formation of small platelet aggregation

Bone Marrow Transplantation

Volumn 29, Issue 2, 2002, Pages 107-111

  Suehiro, A ^a   Sawada, A ^a   Hasegawa, Y ^a   Takatsuka, H ^a   Higasa, S ^a   Kakishita, E ^a  

^a HYOGO COLLEGE OF MEDICINE   (Japan)

Author keywords

Cyclosporine A; Platelets; Serotonin; Tacrolimus

Indexed keywords

ADENOSINE DIPHOSPHATE; CYCLOSPORIN A; SEROTONIN; SEROTONIN ANTAGONIST; TACROLIMUS;

ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; HUMAN; HUMAN CELL; HUMAN EXPERIMENT; INCIDENCE; LIGHT SCATTERING; NORMAL HUMAN; PRIORITY JOURNAL; SEROTONINERGIC SYSTEM; THROMBOCYTE AGGREGATION; THROMBOSIS;

ADENOSINE DIPHOSPHATE; BONE MARROW TRANSPLANTATION; CYCLOSPORINE; DRUG SYNERGISM; HUMANS; IMMUNOSUPPRESSIVE AGENTS; LIGHT; PLATELET AGGREGATION; SCATTERING, RADIATION; SEROTONIN; SEROTONIN ANTAGONISTS; TACROLIMUS; THROMBOPHILIA;

EID: 0036166217     PISSN: 02683369     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bmt.1703335     Document Type: Article

References (20)

1. Cyclosporine-related encephalopathy following allogeneic bone marrow transplantation
2. Cyclosporine A nephrotoxicity: Role of thromboxane and reactive oxygen species
3. Transforming growth factor (TGF)-β mimics and anti-TGF-β antibody abrogates the in vivo effects of cyclosporine: Demonstration of a direct role of TGF-β in immunosuppression and nephrotoxicity of cyclosporine
4. Cyclosporin A enhances platelet aggregation
5. Cyclosporin A augments human platelet sensitivity to aggregating agents by increasing fibrinogen receptor availability
6. The effect of cyclosporine on calcium, protein kinase C, and sodium-proton exchange in platelets
7. The effect of tacrolimus (FK506) and cyclosporin A (CyA) on peripheral serotonergic mechanisms in uremic rats
8. Effects of cyclosporine and FK506 on in vitro high shear-induced platelet reactivity in rat and human non-anticoagulated blood
9. Platelet activation is increased in cyclosporin A-induced hypertensive rats
10. Severe cerebellar swelling and thrombotic thrombocytopenic purpura associated with FK506
11. Aggregation of blood platelets by adenosine diphosphate and its reversal
12. Detection of platelet aggregates with a particle counting method using light scattering
13. Intracellular levels of cyclic AMP and cyclic GMP differentially modify platelet aggregate size in human platelets activated with epinephrine or ADP
14. Platelet aggregating activity of plasma in patients with thrombotic thrombocytopenic purpura evaluated by a particle counting method using light scattering
15. Factors that affect the size of platelet aggregates in epinephrine-induced activation: A study using the particle counting method based upon light scattering
16. Development of large platelet aggregates from small aggregates as determined by laser-light scattering: Effects of aggregant concentration and antiplatelet medication
17. 2A) receptors
18. Cyclosporine-associated thrombotic microangiopathy in renal allografts
19. Pharmacokinetic and pharmacodynamic studies of cyclosporin in bone marrow transplantation
20. Comparative tacrolimus pharmacokinetics: Normal versus mildly hepatically impaired subjects