Pharmacokinetics of ABT-773, a new semi-synthetic ketolide in neutropenic lung-infected mice: A population approach

Journal of Pharmacy and Pharmacology

Volumn 54, Issue 1, 2002, Pages 71-75

  Xuan, D ^a   Ye, M ^a   Kim, M ^a   Nightingale, C H ^a   Nicolau, D P ^a  

^a HARTFORD HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALCOHOL; ANTIINFECTIVE AGENT; BUFFER; CETHROMYCIN; CYCLOPHOSPHAMIDE; KETOLIDE; PHOSPHATE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBIOTIC RESISTANCE; ANTIBIOTIC SENSITIVITY; AREA UNDER THE CURVE; ARTICLE; BACTERICIDAL ACTIVITY; BLOOD SAMPLING; COMPARTMENT MODEL; COMPUTER PROGRAM; CONTROLLED STUDY; DATA ANALYSIS; DOSE RESPONSE; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG DISTRIBUTION; DRUG ELIMINATION; DRUG HALF LIFE; DRUG SCREENING; FEMALE; FLUORESCENCE ANALYSIS; IN VITRO STUDY; LUNG INFECTION; MOUSE; NEUTROPENIA; NONHUMAN; NONLINEAR SYSTEM; POPULATION MODEL; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; STREPTOCOCCUS PNEUMONIA; STREPTOCOCCUS PNEUMONIAE;

ADMINISTRATION, ORAL; ANIMALS; AREA UNDER CURVE; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; ERYTHROMYCIN; FEMALE; HALF-LIFE; INTESTINAL ABSORPTION; KETOLIDES; METABOLIC CLEARANCE RATE; MICE; MICE, INBRED ICR; NEUTROPENIA; RESPIRATORY TRACT INFECTIONS; TISSUE DISTRIBUTION;

EID: 0036165919     PISSN: 00223573     EISSN: None     Source Type: Journal    
DOI: 10.1211/0022357021771940     Document Type: Article

References (10)

1. In vivo activities of amoxicillin and amoxicillin-clavulanate against Streptococcus pneumoniae: Application to breakpoint determinations
2. In vivo pharmacodynamics of ABT-773, a new ketolide antibiotic
3. Ketolides: New semisynthetic 14-membered-ring macrolides
4. In vitro and in vivo metabolism of ABT-773
5. Pharmacokinetics and safety of single doses of ABT-773 in healthy subjects
6. Use of a new mouse model of Acinetobacter baumannii pneumonia to evaluate the postantibiotic effect of imipenem
7. Influence of adjunct azithromycin on the outcome of experimental Pseudomonas aeruginosa pneumonia
8. Pharmacodynamic assessment of cefprozil against Streptococcus pneumoniae: Implications for breakpoint determinations
9. The in vitro activities of ABT-773, telithromycin and other macrolides against Canadian Streptococci
10. ABT-773 demonstrates excellent in vitro activity against macrolide-resistant respiratory isolates of Streptococcus pneumoniae with mefA or ermB genotypes