Impurity profiling of pholcodine by liquid chromatography electrospray ionization mass spectrometry (LC-ESI-MS)

Journal of Pharmacy and Pharmacology

Volumn 54, Issue 1, 2002, Pages 87-98

  Denk, Oliver M ^a   Skellern, Graham G ^a   Watson, David G ^a  

^a UNIVERSITY OF STRATHCLYDE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

10 HYDROXYPHOLCODINE; 3 CHLOROPERBENZOIC ACID; CHROMIC ACID; HYDROXYL GROUP; MORPHINE; PHOLCODINE; PHOLCODINE DI N,N' OXIDE; PHOLCODINE N OXIDE; UNCLASSIFIED DRUG;

ARTICLE; DRUG DETERMINATION; DRUG IDENTIFICATION; DRUG IMPURITY; DRUG ISOLATION; DRUG STRUCTURE; DRUG SYNTHESIS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; MICELLAR ELECTROKINETIC CHROMATOGRAPHY; OXIDATION; STRUCTURE ANALYSIS;

ANTITUSSIVE AGENTS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CHROMATOGRAPHY, LIQUID; CODEINE; DRUG CONTAMINATION; MORPHOLINES; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION;

EID: 0036162496     PISSN: 00223573     EISSN: None     Source Type: Journal    
DOI: 10.1211/0022357021771788     Document Type: Article

References (12)

1. Some tenets pertaining to electrospray ionisation mass spectrometry
2. Isolation and identification of three potential impurities of pholcodine bulk drug substance
3. Micellar electrokinetic and high-performance liquid chromatographic determination of potential manufacturing impurities in pholcodine
4. The use of hypenated LC-MS technique for characterisation of impurity profiles during drug development
5. Drug impurity profiling strategies
6. Synthetic drugs with morphine action
7. N-oxides of morphine, codeine and thebaine and their occurrence in Papaver species
8. Separation of morphine and its oxidation products by capillary zone electrophoresis
9. 10-Hydroxymorphine
10. (2-Morpholinoethyl)-morphine