Activation of the cardiac endothelin system in left ventricular hypertrophy before onset of heart failure in TG(mREN2)27 rats

Cardiovascular Research

Volumn 53, Issue 2, 2002, Pages 363-371

  Zolk, Oliver ^a   Quattek, Jessika ^b   Seeland, Ute ^b   El Armouche, Ali ^a   Eschenhagen, Thomas ^a   Böhm, Michael ^b  

^a UNIVERSITY HOSPITAL ERLANGEN   (Germany)

^b SAARLAND UNIVERSITY   (Germany)

Author keywords

Endothelins; Hypertension; Hypertrophy; Renin angiotensin system

Indexed keywords

ANGIOTENSIN; DIPEPTIDYL CARBOXYPEPTIDASE; ENDOTHELIN; ENDOTHELIN A RECEPTOR; ENDOTHELIN B RECEPTOR; ENDOTHELIN CONVERTING ENZYME; ENZYME; MESSENGER RNA;

AGE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BINDING SITE; CONGESTIVE CARDIOMYOPATHY; CONTROLLED STUDY; DISEASE ASSOCIATION; DISEASE COURSE; DISEASE SEVERITY; ENZYME ACTIVITY; GENE OVEREXPRESSION; HEART FAILURE; HEART LEFT VENTRICLE FAILURE; HEART LEFT VENTRICLE HYPERTROPHY; HYPERTENSION; MUTATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN SYNTHESIS; RAT; RAT STRAIN; RECEPTOR UPREGULATION; REGULATORY MECHANISM; RENIN ANGIOTENSIN ALDOSTERONE SYSTEM;

ANGIOTENSIN II; ANIMALS; ANIMALS, GENETICALLY MODIFIED; ASPARTIC ENDOPEPTIDASES; COLLAGEN; ENDOTHELIN-1; HYPERTENSION; HYPERTROPHY, LEFT VENTRICULAR; IMMUNOHISTOCHEMISTRY; MALE; METALLOENDOPEPTIDASES; MODELS, ANIMAL; MYOCARDIUM; PEPTIDYL-DIPEPTIDASE A; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, ENDOTHELIN; RENIN; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER;

EID: 0036162403     PISSN: 00086363     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0008-6363(01)00468-0     Document Type: Article

References (30)

1. Role of blood pressure in the development of congestive heart failure. The Framingham study
2. Natriuretic peptides inhibit angiotensin II-induced proliferation of rat cardiac fibroblasts by blocking endothelin-1 gene expression
3. Endothelin-1 is an autocrine/paracrine factor in the mechanism of angiotensin II-induced hypertrophy in cultured rat cardiomyocytes
4. Differential modulation of the renal and myocardial endothelin system by angiotensin II in vivo. Effects of chronic selective ETA receptor blockade
5. Interactions between endothelin-1 and the renin-angiotensin-aldosterone system
6. Short- and long-term determinants of cardiovascular function and therapy: Contributions of circulating and tissue renin-angiotensin systems
7. 2+ uptake
8. Validity of an indirect tail-cuff method for determining systolic arterial pressure in unanesthetized normotensive and spontaneously hypertensive rats
9. Expression of endothelin-1, endothelin-converting enzyme, and endothelin receptors in chronic heart failure
10. Spectrophotometric assay and properties of the angiotensin-converting enzyme of rabbit lung
11. 2+-ATPase expression in the sarcoplasmic reticulum in hypertensive cardiomyopathy
12. Effects of quinapril, losartan and hydralazine on cardiac hypertrophy and beta-adrenergic neuroeffector mechanisms in transgenic (mREN2)27 rats
13. Differential gene expression of renin and angiotensinogen in the TGR(mREN-2)27 transgenic rat
14. Endogenous endothelin-1 participates in the maintenance of cardiac function in rats with congestive heart failure. Marked increase in endothelin-1 production in the failing heart
15. Expression of endothelin-1, ETA and ETB receptors, and ECE and distribution of endothelin-1 in failing rat heart
16. Cardiac endothelin-1 plays a critical role in the functional deterioration of left ventricles during the transition from compensatory hypertrophy to congestive heart failure in salt-sensitive hypertensive rats
17. Endothelin system-dependent cardiac remodeling in renovascular hypertension
18. Endothelin ETA receptor antagonist blocks cardiac hypertrophy provoked by hemodynamic overload
19. Endothelin-1 and its binding sites are upregulated in pressure overload cardiac hypertrophy
20. Angiotensin II stimulates cardiac myocyte hypertrophy via paracrine release of TGF-beta 1 and endothelin-1 from fibroblasts
21. B receptor subtype mRNA by angiotensin II in rat cardiomyocytes
22. Angiotensin II up-regulates the expression of type A endothelin receptor in human vascular smooth muscle cells
23. Induction of immediate-early genes by angiotensin II and endothelin-1 in adult rat cardiomyocytes
24. Effects of endothelins on collagen turnover in cardiac fibroblasts
25. Myocardial remodeling in hypertensive Ren-2 transgenic rats
26. Contractile systolic and diastolic dysfunction in renin-induced hypertensive cardiomyopathy
27. Cardiovascular end-organ damage in Ren-2 transgenic rats compared to spontaneously hypertensive rats
28. 2+ ATPase (SERCA2) gene expression and calcium reuptake
29. Mechanical strain increases endothelin-1 gene expression via protein kinase C pathway in human endothelial cells
30. Endothelin-1 is involved in mechanical stress-induced cardiomyocyte hypertrophy