Uptake of lamivudine by rat renal brush border membrane vesicles

Journal of Pharmacy and Pharmacology

Volumn 54, Issue 1, 2002, Pages 111-117

  Takubo, T ^a   Kato, T ^a   Kinami, J ^a   Hanada, K ^b   Ogata, H ^b  

^a Development and Medical Affairs Division   (Japan)

^b MEIJI PHARMACEUTICAL UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE; ANTIPORTER; ANTIVIRUS AGENT; CATION; CIMETIDINE; DEOXYADENOSINE; DIPYRIDAMOLE; FLOXURIDINE; LAMIVUDINE; LAMIVUDINE H 3; NITROBENZYLTHIOINOSINE; NUCLEOSIDE ANALOG; RADIOPHARMACEUTICAL AGENT; TRIMETHOPRIM; UNCLASSIFIED DRUG; ZALCITABINE; ZIDOVUDINE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; COMPETITIVE INHIBITION; CONTROLLED STUDY; DOSE RESPONSE; DRUG ANTAGONISM; DRUG EXCRETION; DRUG TRANSPORT; INHIBITION KINETICS; ISOTOPE LABELING; KIDNEY CORTEX; KIDNEY TUBULE EPITHELIUM; KIDNEY TUBULE EXCRETION; NONHUMAN; NUCLEOSIDE TRANSPORT; PH MEASUREMENT; RAT; REGULATORY MECHANISM;

ANIMALS; ANTI-HIV AGENTS; ANTIMALARIALS; BIOLOGICAL TRANSPORT; CIMETIDINE; DRUG INTERACTIONS; ION TRANSPORT; KIDNEY CORTEX; LAMIVUDINE; METABOLIC CLEARANCE RATE; MICROVILLI; RATS; TRIMETHOPRIM;

EID: 0036162333     PISSN: 00223573     EISSN: None     Source Type: Journal    
DOI: 10.1211/0022357021771814     Document Type: Article

References (34)

1. Effect of probenecid and cimetidine on the renal excretion of 3′-azido-3′-deoxythymidine in rats
2. +-independent nucleoside transporters in Xenopus laevis oocyte
3. Deoxycytidine deaminase-resistant stereoisomer is the active form of (±)-2′,3′-dideoxy-3′-thiacytidine in the inhibition of hepatitis B virus replication
4. Role of organic cation transporters in the renal secretion of nucleosides
5. (-)-2′-Deoxy-3′-thiacytidine is a potent, highly selective inhibitor of human immunodeficiency virus type 1 and type 2 replication in vitro
6. The high and low affinity transport systems for dipeptides in kidney brush border membrane respond differently to alterations in pH gradient and membrane potential
7. +/organic cations in the rat proximal tubule
8. Inhibition of the replication of hepatitis B virus in vitro by 2′-3′-dideoxy-3′-thiacytidine and related analogues
9. Nucleoside and nucleobase transport systems of mammalian cells
10. Effect of 3′-azido-3′-deoxythymidine (AZT) on organic ion transport in rat renal brush border membrane vesicles
11. Repeated administration of trimethoprim/sulfadiazine in the horse - Pharmacokinetics, plasma protein binding and influence on the intestinal microflora
12. Effects of (-)-2′-deoxy-3′-thiacytidine (3TC) 5′-triphosphate on human immunodeficiency virus reverse transcriptase and mammalian DNA polymerase alpha, beta, and gamma
13. Transport of bestatin in rat renal brush-border membrane vesicles
14. Interactions of organic anions with the organic cation transporter in renal BBMV
15. Phamacokinetics of 2′3′-dideoxycytidine after high-dose administration to rats
16. Clinical pharmacokinetics of lamivudine
17. Role of p-glycoprotein in the renal transport of dideoxynucleoside analog drugs
18. Uptake properties of lamivudine (3TC) by a continuous renal epithelial cell line
19. Identification of p-glycoprotein in renal brush border membranes
20. Transport of organic cation in renal brush-border membrane from rats with renal ischemic injury
21. Pharmacokinetics of lamivudine administered alone and with trimethoprim-sulfamethoxazole
22. Transport studies in plasma membrane vesicles isolated from renal cortex
23. Renal transepithelial transport of nucleoside
24. Pharmacokinetics of a sulphamethoxazole/trimethoprim formulation in pigs after intravenous administration
25. Pharmacokinetics and saturable renal tubular secretion of zidovudine in rats
26. Renal disposition and drug interaction screening of (-)-2′-deoxy-3′-thiacytidine (3TC) in the isolated perfused rat kidney
27. The transport mechanism of an organic cation, disopyramide, by brush-border membranes
28. Studies on the metabolic fate of lamivudine (I)
29. Effect of trimethoprim on the renal clearance of lamivudine in rats
30. Effect of lamivudine on uptake of organic cations by rat renal brush-border and basolateral membrane vesicles
31. Phase I study of GG714 (lamivudine): Evaluation of safety and pharmacokinetics of single and multiple dose administration
32. Pharmacokinetics of trimethoprim in the rat
33. Rat multispecific organic anion transporter 1 (rOAT1) transports zidovudine, acyclovir, and other antiviral nucleoside analogs
34. + exchanger of the renal luminal membrane