Twenty-six-week repeat-dose toxicity study of a recombinant human granulocyte colony-stimulating factor derivative (nartograstim) in cynomolgus monkeys

Toxicological Sciences

Volumn 65, Issue 2, 2002, Pages 246-255

  Okasaki, Keikou ^a,b   Funato, Mamoru ^b   Kashima, Masatoshi ^b   Nakama, Kazuhiro ^b   Inoue, Takatoshi ^c   Hiura, Masanori ^c   Kato, Yuzuru ^c   Nagata, Ryoichi ^a,b  

^a SNBL USA Ltd   (United States)

^b SHIN NIPPON BIOMEDICAL LABORATORIES LTD   (Japan)

^c KYOWA HAKKO KOGYO CO LTD   (Japan)

Author keywords

Anemia; Cynomolgus monkey; Granulocytosis; Nartograstim; No observed adverse effect level; rhG CSF derivative

Indexed keywords

ALKALINE PHOSPHATASE; CHOLESTEROL; NEUTRALIZING ANTIBODY; RECOMBINANT GRANULOCYTE COLONY STIMULATING FACTOR;

ANEMIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBODY DETECTION; ANTIBODY TITER; ARTICLE; BONE MARROW; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; DOSE RESPONSE; ENZYME ACTIVITY; ERYTHROCYTE COUNT; FEMALE; GRANULOCYTOSIS; LEUKOCYTOSIS; MALE; MONKEY; NEUTROPHIL; NONHUMAN; RETICULOCYTE; SPLENOMEGALY;

ALKALINE PHOSPHATASE; ANEMIA; ANIMALS; ANTINEOPLASTIC AGENTS; BONE MARROW; CHOLESTEROL; CLINICAL CHEMISTRY TESTS; DOSE-RESPONSE RELATIONSHIP, DRUG; ERYTHROCYTE INDICES; FEMALE; GRANULOCYTE COLONY-STIMULATING FACTOR; INJECTIONS, SUBCUTANEOUS; MACACA FASCICULARIS; MALE; NEUTROPHILS; NO-OBSERVED-ADVERSE-EFFECT LEVEL; SPLEEN;

ANIMALIA; MACACA FASCICULARIS;

EID: 0036161098     PISSN: 10966080     EISSN: None     Source Type: Journal    
DOI: 10.1093/toxsci/65.2.246     Document Type: Article

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