Evaluation of genotoxic and cytotoxic potential of thiola (N-2-mercaptopropionylglycine), a medicine used in the treatment of humans contaminated with mercury

Environmental and Molecular Mutagenesis

Volumn 39, Issue 1, 2002, Pages 18-21

  Formigli, Lia M ^a   Ferrari, Iris ^a   Grisolia, Cesar K ^a  

^a INSTITUTO DE CIÊNCIAS BIOLÓGICAS   (Brazil)

Author keywords

Chromosomal aberrations; Mercaptopropionylglycine; Micronucleus; Thiola; Tiopronin

Indexed keywords

BLEOMYCIN; CYCLOPHOSPHAMIDE; MERCURY; TIOPRONIN;

ADULT; ANIMAL EXPERIMENT; ANTIOXIDANT ACTIVITY; ARTICLE; CHROMOSOME ABERRATION; CONTROLLED STUDY; CYTOTOXICITY; FEMALE; FISH; FOOD CONTAMINATION; GENOTOXICITY; HUMAN; HUMAN CELL; MALE; MERCURIALISM; MICRONUCLEUS; MINAMATA DISEASE; MOUSE; NONHUMAN; POLLUTION;

ANIMALS; BLEOMYCIN; CHROMOSOME ABERRATIONS; CYCLOPHOSPHAMIDE; FEMALE; HUMANS; LYMPHOCYTES; MALE; MERCURY POISONING; MICE; MICRONUCLEUS TESTS; THIOPRONINE;

EID: 0036160082     PISSN: 08936692     EISSN: None     Source Type: Journal    
DOI: 10.1002/em.10035     Document Type: Article

References (17)

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7. Sporadic chromosome abnormalities in human lymphocytes and previous exposure to chemicals
8. Trimmed Spearman-Karber method for estimating median lethal concentration in toxicity bioassays
9. The pharmacokinetics of tiopronin and its principal metabolite (2-mercaptopropionic acid) after oral administration to healthy volunteers
10. Distribution of human chromosome counts in relation to age
11. Ten model mutagens evaluated by the micronucleus test
12. Chromosomes preparations of leukocytes cultured from human peripheral blood
13. Chronic toxicities of alpha-mercaptopropionylglycine (Thiola) and alpha(S-benzoylmercapto) propionylglycine (Benzoylthiola) on rat orally administered
14. Genetic toxicological testing of some plant flavonoids by the micronucleus test
15. The micronucleus test
16. Thiopronin reduces the frequencies of neocarzinostatin-induced chromosomal aberrations and sister chromatid exchanges in Chinese hamster ovary cells