A new laser pain threshold model detects a faster onset of action from a liquid formulation of 1 g paracetamol than an equivalent tablet formulation

British Journal of Clinical Pharmacology

Volumn 53, Issue 1, 2002, Pages 43-47

  Kilminster, S G ^a   Sutton, J A ^a   Gillin, W P ^b   Clarke, G D ^c   Grattan, T J ^c  

^a ROYAL SURREY COUNTY HOSPITAL   (United Kingdom)

^b QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

^c GLAXOSMITHKLINE   (United Kingdom)

Author keywords

Consistency of laser pain threshold; Paracetamol liquid vs tablet formulations

Indexed keywords

CAPLETS; PARACETAMOL;

ADULT; AGED; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DOSE RESPONSE; DOUBLE BLIND PROCEDURE; DRUG ABSORPTION; DRUG MECHANISM; FEMALE; FOREARM; HUMAN; INFRARED RADIATION; LIQUID; MALE; NORMAL HUMAN; PAIN THRESHOLD; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; TABLET FORMULATION;

ACETAMINOPHEN; ADOLESCENT; ADULT; AGED; ANALGESICS, NON-NARCOTIC; ANALYSIS OF VARIANCE; CAPSULES; CHEMISTRY, PHARMACEUTICAL; CONFIDENCE INTERVALS; CROSS-OVER STUDIES; DOUBLE-BLIND METHOD; FEMALE; HUMANS; INFRARED RAYS; LASERS; MALE; MIDDLE AGED; PAIN THRESHOLD; PHARMACEUTICAL SOLUTIONS; TABLETS; THERAPEUTIC EQUIVALENCY;

EID: 0036159703     PISSN: 03065251     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.0306-5251.2001.01527.x     Document Type: Article

References (16)

1. Comparison of four laser types for experimental pain stimulation on oral mucosa and hairy skin
2. A comparison of the hypoalgesic effect of paracetamol in slow release and plain tablets on laser induced pain
3. Analgesic efficacy of non-steroidal anti-inflammatory drugs in experimental pain in humans
4. Perceived control and the cold pressor test
5. A new model of laser induced pain differentiates between onset times of analgesia from liquid and capsule formulations of a codeine-paracetamol combination
6. Impaired absorption of paracetamol in vegetarians
7. Kinetics of acetaminophen absorption and gastric emptying in man
8. Analgesic efficacy of immediate and sustained release paracetamol and plasma concentration of paracetamol. Double blind, placebo controlled evaluation using painful laser stimulation
9. A comparison of the absorption of two formulations of paracetamol
10. A comparison of the absorption of effervescent paracetamol and penicillin V (phenoxymethylpenicillin) with solid dose forms of these drugs
11. A study of human absorption of an effervescent preparation of paracetamol
12. The analgesic effect of paracetamol depends on its method of administration
13. Comparative bioavailability of aspirin and paracetamol following single dose administration of soluble and plain tablets