Potentiation of cell killing by low-dose-rate radiation by camptothecin is related to an increase in the level of DNA double-strand breaks

Radiation Research

Volumn 157, Issue 2, 2002, Pages 149-157

  Owen, Daron G ^a   McNamee, James P ^a   Raaphorst, G Peter ^a   Ng, Cheng E ^a  

^a OTTAWA REGIONAL CANCER CENTRE   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CAMPTOTHECIN; DOUBLE STRANDED DNA;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL DESTRUCTION; CANCER RADIOTHERAPY; CELL KILLING; CELL SURVIVAL; CONCENTRATION RESPONSE; CONTROLLED STUDY; DNA STRAND BREAKAGE; HUMAN; HUMAN CELL; LOW ENERGY RADIATION; MELANOMA CELL; PRIORITY JOURNAL; RADIATION DOSE;

EID: 0036158255     PISSN: 00337587     EISSN: None     Source Type: Journal    
DOI: 10.1667/0033-7587(2002)157[0149:POCKBL]2.0.CO;2     Document Type: Article

References (27)

1. Pelvic radiation with concurrent chemotherapy compared with pelvic and para-aortic radiation for high risk cervical cancer
2. Chemoradiation of locally advanced esophageal cancer: Long-term follow up of a prospective randomized trial
3. Improving adjuvant therapy for rectal cancer by combining protracted infusion of fluorouracil with radiation therapy after curative surgery
4. The inhibition of cellular recovery in human tumor cells by inhibitors of topoisomerase
5. Posttreatment exposure to camptothecin enhances the lethal effects of X-rays on radioresistant human malignant melanoma cells
6. Inhibition of potentially lethal and sublethal damage repair by camptothecin and etoposide in human melanoma cell lines
7. Mammalian DNA topoisomerase I mediates the enhancement of radiation cytotoxicity by camptothecin derivatives
8. Potentiation of radiation response in human carcinoma cells in vitro and murine fibrosarcoma in vivo by topotecan
9. Potentiation of murine MCa-4 carcinoma response by 9-amino-20(S)CPT
10. Radiation enhancement by 9-aminocamptothecin: The effect of fractionation and timing of administration
11. Enhancement of tumor radioresponse by irinotecan in human lung tumor xenografts
12. Camptothecin radiation sensitivity: Mechanisms, schedules and timing
13. Review of phase I clinical studies with topotecan
14. Interaction of ionizing radiation with the topoisomerase I poison camptothecin in growing V-79 and HeLa cells
15. Potentiation of radioimmunotherapy by inhibition of topoisomerase I
16. The dose-rate effect revisited: Radiobiological considerations of importance in radiotherapy
17. DNA topoisomerase content of a pair of human melanoma cell lines with very different radiosensitivities correlates with their in vitro sensitivities to camptothecin
18. Effect of protracted mild hyperthermia on polymerase activity in a human melanoma cell line
19. Exploitable mechanisms in combined radiotherapy-chemotherapy
20. Rejoining of DNA singleand double-strand breaks in human white blood cells exposed to ionizing radiation
21. Comet assay: Rapid processing of multiple samples
22. Gamma irradiation as a probe of chromatin structure: Damage and repair of chromatin in the metaphase chromosome
23. Detection of subpopulations resistant to DNA-damaging agents in spheroids and murine tumours