Lisofylline: Anti-acute respiratory distress syndrome or just anti-inflammatory?

Critical Care Medicine

Volumn 30, Issue 1, 2002, Pages 246-247

  Lynch, Robert E ^a  

^a SAINT LOUIS UNIVERSITY   (United States)

Author keywords

Acute respiratory distress syndrome; Acyl ratio; Anti inflammatory; Lisophylline; Phosphatidic acid; Sepsis

Indexed keywords

BACTERIUM LIPOPOLYSACCHARIDE; ENDOTOXIN; INTERLEUKIN 12; INTERLEUKIN 1BETA; INTERLEUKIN 6; LISOFYLLINE; PENTOXIFYLLINE; PHOSPHATIDIC ACID; TUMOR NECROSIS FACTOR ALPHA;

ANTIINFLAMMATORY ACTIVITY; CLINICAL TRIAL; CYTOKINE PRODUCTION; DRUG EFFICACY; DRUG MECHANISM; EDITORIAL; HEART RATE; HUMAN; LEUKEMIA CELL; LEUKOCYTE ACTIVATION; LUNG INJURY; MEDICAL RESEARCH; METHODOLOGY; MORTALITY; NONHUMAN; PEER REVIEW; PRIORITY JOURNAL; QT INTERVAL; RESPIRATORY DISTRESS; TH1 CELL; TREATMENT OUTCOME; TREATMENT PLANNING;

EID: 0036156866     PISSN: 00903493     EISSN: None     Source Type: Journal    
DOI: 10.1097/00003246-200201000-00037     Document Type: Editorial

References (16)

1. Randomized, placebo-controlled trial of lisofylline for early treatment of acute lung injury and acute respiratory distress syndrome
2. Protection from endotoxic shock in mice by pharmacologic inhibition phosphatidic acid
3. CT-1501R selectively inhibits induced inflammatory monokines in human whole blood ex vivo
4. Potential role for phosphatidic acid in mediating the inflammatory responses to TNFα and IL-1β
5. Selective pharmacologic inhibition of murine and human IL-12-dependent Th1 differentiation and IL-12 signaling
6. Lisofylline suppresses ex vivo release by murine spleen cells of hemopoietic inhibitors induced by cancer chemotherapeutic agents
7. Selective downregulation of neutrophils by a phosphatidic acid generation inhibitor in a porcine sepsis model
8. Lisofylline ameliorates intestinal and hepatic injury induced by hemorrhage and resuscitation in rats
9. Perioperative treatment with phosphatidic acid inhibitor (Lisofylline) leads to prolonged survival of hearts in the guinea pig to rat xenotransplant model
10. Prevention of experimental allergic encephalomyelitis via inhibition of IL-12 signaling and IL-12-mediated Th1 differentiation: An effect of the novel anti-inflammatory drug lisofylline
11. Phosphatidic acid signaling mediates lung cytokine expression and lung inflammatory injury after hemorrhage in mice
12. Lisofylline decreases white cell adhesiveness and improves survival after experimental hemorrhagic shock
13. The effects of post-treatment with lisofylline, a phosphatidic acid generation inhibitor, on sepsis-induced acute lung injury in pigs
14. Effects of lisofylline on hyperoxia-induced lung injury
15. A randomized placebo-controlled trial of lisofylline in HLA-identical, sibling-donor, allogenic bone marrow transplant recipients
16. An increase in serum C18 unsaturated free fatty acids as a predictor of the development of acute respiratory distress syndrome