Protective immune responses to the 42-kilodalton (kDa) region of Plasmodium yoelii merozoite surface protein 1 are induced by the C-terminal 19-kDa region but not by the adjacent 33-kDa region

Infection and Immunity

Volumn 70, Issue 2, 2002, Pages 820-825

  Ahlborg, Niklas ^a   Ling, Irene T ^a   Howard, Wendy ^a   Holder, Anthony A ^a   Riley, Eleanor M ^a  

^a LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

GLUTATHIONE TRANSFERASE; HYBRID PROTEIN; IMMUNOGLOBULIN G; MEROZOITE SURFACE PROTEIN 1;

AMINO TERMINAL SEQUENCE; ANIMAL MODEL; ANTIBODY RESPONSE; ANTIBODY TITER; ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL COUNT; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; GENETIC CODE; HELPER CELL; IMMUNE RESPONSE; IMMUNOFLUORESCENCE; MOUSE; NONHUMAN; PLASMODIUM YOELII; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; VACCINE PRODUCTION;

ANIMALS; ANTIBODIES, PROTOZOAN; ENZYME-LINKED IMMUNOSORBENT ASSAY; EPITOPES, B-LYMPHOCYTE; FEMALE; FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT; GLUTATHIONE TRANSFERASE; MALARIA; MEROZOITE SURFACE PROTEIN 1; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; MOLECULAR WEIGHT; PLASMODIUM YOELII; RECOMBINANT FUSION PROTEINS; VACCINATION;

EID: 0036156061     PISSN: 00199567     EISSN: None     Source Type: Journal    
DOI: 10.1128/IAI.70.2.820-825.2002     Document Type: Article

References (38)

1. 19
2. A single fragment of a malaria merozoite surface protein remains on the parasite during red cell invasion and is the target of invasionblocking antibodies
3. 33 as a noncovalently associated complex with other fragments of the MSP1
4. Antibodies inhibit the protease-mediated processing of a malaria merozoite surface protein
5. Immunization of Aotus nancymai with recombinant C terminus of Plasmodium falciparum merozoite surface protein 1 in liposomes and alum adjuvant does not induce protection against a challenge infection
6. A recombinant baculovirus 42-kilodalton C-terminal fragment of Plasmodium falciparum merozoite surface protein 1 protects Aotus monkeys against malaria
7. Humoral response to a carboxyl-terminal region of the merozoite surface protein-1 plays a predominant role in controlling blood-stage infection in rodent malaria
8. A recombinant 15-kilodalton carboxylterminal fragment of Plasmodium yoelii yoelii 17XL merozoite surface protein 1 induces a protective immune response in mice
9. Antibody levels to conserved parts of Plasmodium falciparum merozoite surface protein 1 (PfMSP1) in Ghanaian children are not associated with protection from clinical malaria
10. Characterization of human T- and B-cell epitopes in the C terminus of Plasmodium falciparum merozoite surface protein 1: Evidence for poor T-cell recognition of polypeptides with numerous disulfide bonds
11. Vaccine efficacy of recombinant Plasmodium falciparum merozoite surface protein 1 in malarianaive, -exposed and/or -rechallenged Aotus vociferans monkeys
12. 19, the carboxy-terminal fragment of the major merozoite surface protein of Plasmodium falciparum
13. Calculation of protein extinction coefficients from amino acid sequence data
14. Antibodies that inhibit malaria merozoite surface protein-1 processing and erythrocyte invasion are blocked by naturally acquired human antibodies
15. Complete protective immunity induced in mice by immunization with the 19-kilodalton carboxyl-terminal fragment of the merozoite surface protein-1 (MSP1[19]) of Plasmodium yoelii expressed in Saccharomyces cerevisiae: Correlation of protection with antigen-specific antibody titer, but not with effector CD4+ T cells
16. Absolute requirement for an active immune response involving B cells and Th cells in immunity to Plasmodium yoelii passively acquired with antibodies to the 19-kDa carboxyl-terminal fragment of merozoite surface protein-1
17. Characterization of a high molecular weight protective antigen of Plasmodium yoelii
18. Processing of the precursor to the major merozoite surface antigens of Plasmodium falciparum
19. Immunogenicity and in vivo efficacy of recombinant Plasmodium falciparum merozoite surface protein-I in Aotus monkeys
20. Cloning and analysis of the gene encoding the 230kilodalton merozoite surface antigen of Plasmodium yoelii
21. Immunization against malaria with a recombinant protein
22. Immunization against the murine malaria parasite Plasmodium yoelii using a recombinant protein with adjuvants developed for clinical use
23. Passive immunization against murine malaria with an IgG3 monoclonal antibody
24. Fragments of the polymorphic Mr185,000 glycoprotein from the surface of isolated Plasmodium falciparum merozoites form an antigenic complex
25. Chemotherapy of Plasmodium chabaudi infection in albino mice
26. A longitudinal study of naturally acquired cellular and humoral immune responses to a merozoite surface protein (MSP1) of Plasmodium falciparum in an area of seasonal malaria transmission
27. Fc receptors are not required for antibody-mediated protection against lethal malaria challenge in a mouse model
28. Natural immune response to the C-terminal 19-kilodalton domain of Plasmodium falciparum merozoite surface protein 1
29. Merozoite surface coat precursor protein completely protects Aotus monkeys against Plasmodium falciparum malaria
30. Single step purification of polypeptides expressed in Escherichia coli as fusions with glutathione S-transferase
31. Passive immunization with antibodies against three distinct epitopes on Plasmodium yoelii merozoite surface protein 1 suppresses parasitemia
32. Efficacy of two alternate vaccines based on Plasmodium falciparum merozoite surface protein 1 in an Aotus challenge trial
33. Genetic regulation of protective immune response in congenic strains of mice vaccinated with a subunit malaria vaccine
34. Comparison of protection induced by immunization with recombinant proteins from different regions of merozoite surface protein 1 of Plasmodium yoelii
35. Prospective study of the association between the human humoral immune response to Plasmodium falciparum blood stage antigen gp190 and control of malaria infections
36. Identification of T and B cell epitopes recognized by humans in the C-terminal 42-kDa domain of the Plasmodium falciparum merozoite surface protein (MSP)-1
37. Inhibitory and blocking monoclonal antibody epitopes on merozoite surface protein 1 of the malaria parasite Plasmodium falciparum
38. Sudden increase in virulence in a strain of Plasmodium berghei yoelii