Tumor-specific mutations in p53: The acid test

Nature Medicine

Volumn 8, Issue 1, 2002, Pages 21-23

  Hainaut, Pierre ^a  

^a INTERNATIONAL AGENCY FOR RESEARCH ON CANCER   (France)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN P53;

ADRENAL CORTEX CARCINOMA; DNA BINDING MOTIF; DNA DAMAGE; FAMILIAL CANCER; GENE MUTATION; HUMAN; HYPOXIA; PENETRANCE; PH; PRIORITY JOURNAL; SHORT SURVEY; TUMOR SUPPRESSOR GENE;

ADRENAL CORTEX NEOPLASMS; ADRENOCORTICAL CARCINOMA; CHILD; GENES, P53; GERM-LINE MUTATION; HUMANS; LI-FRAUMENI SYNDROME; LIVER NEOPLASMS;

EID: 0036155002     PISSN: 10788956     EISSN: None     Source Type: Journal    
DOI: 10.1038/nm0102-21     Document Type: Short Survey

References (8)

1. The p53 tumor suppressor gene: The first ten thousand mutations
2. Germ line p53 mutations in a familial syndrome of breast cancer, sarcomas, and other neoplasms
3. A novel mechanism of tumorigenesis involving pH-dependent destabilization of a mutant p53 tetramer
4. An inherited p53 mutation that contributes in a tissue-specific manner to pediatric adrenal cortical carcinoma
5. Characterization of p53 oligomerization domain mutations isolated from Li-Fraumeni and Li-Fraumeni like family members
6. Crystal structure of the tetramerization domain of the p53 tumor suppressor at 1.7 angstroms
7. Proliferation and apoptosis in the human adrenal cortex during the fetal and perinatal periods: Implications for growth and remodeling
8. Relative frequency and morphology of cancers in carriers of germline TP53 mutations