Cytokine signaling in sepsis: Redundancy, crosstalk, and regulatory mechanisms

Critical Care Medicine

Volumn 30, Issue 1, 2002, Pages 262-263

  Cooney, Robert N ^a   Yumet, Gladys ^a  

^a PENNSYLVANIA STATE UNIVERSITY   (United States)

Author keywords

Cytokine signaling; Endotoxin; Interleukin 6; Janus kinases; Signal transducers and activators of transcription

Indexed keywords

CYTOKINE; ENDOTOXIN; INTERLEUKIN 1; INTERLEUKIN 6; JANUS KINASE; TUMOR NECROSIS FACTOR;

ACUTE PHASE RESPONSE; CYTOKINE PRODUCTION; EDITORIAL; ENDOTOXEMIA; HUMAN; HUMAN CELL; INFLAMMATION; PHOSPHORYLATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; REACTION ANALYSIS; SEPSIS; SIGNAL TRANSDUCTION;

EID: 0036152712     PISSN: 00903493     EISSN: None     Source Type: Journal    
DOI: 10.1097/00003246-200201000-00048     Document Type: Editorial

References (17)

1. Biologic control of inflammation: Much more than too little or too late
2. Acute-phase proteins and other systemic responses to inflammation
3. Shock and tissue injury induced by recombinant human cachectin
4. Interleukin-1 induces a shock-like state in rabbits. Synergism with tumor necrosis factor and the effect of cyclooxygenase inhibition
5. Anticachectin/TNF monoclonal antibodies prevent septic shock during lethal bacteremia
6. IL-Ira attenuates sepsis-induced alterations in the IGF system and protein synthesis
7. Effects of cytokine antagonists on the hepatic acute phase response
8. Tumor necrosis factor binding protein does not attenuate hepatic protein synthesis in sepsis
9. Recombinant human interleukin-1 receptor antagonist in the treatment of patients with sepsis syndrome
10. Double-blind randomized controlled trial of monoclonal antibody to human tumour necrosis factor in treatment of septic shock
11. Prevention of skeletal muscle catabolism in sepsis does not impair visceral protein metabolism
12. Inhibition of interleukin-6-activated janus kinase/signal transducers and activators of transcription but not mitogen-activated protein kinase signaling in liver of endotoxin-treated rats
13. Endotoxin-induced inhibition of growth hormone signaling in rat liver in vivo
14. A novel cytokine-inducible gene CIS encodes an SH2-containing protein that binds to tyrosinephosphorylated interleukin 3 and erythropoietin receptors
15. A family of cytokine-inducible inhibitors of signaling
16. A new protein containing an SH2 domain that inhibits JAK kinases
17. Structure and function of a new family of STAT-induced STAT inhibitor