Comparative pharmacodynamics of azithromycin roxithromycin with S. pyogenes and S. pneumoniae in a model that simulates in vitro pharmacokinetics in human tonsils

Journal of Antimicrobial Chemotherapy

Volumn 49, Issue 1, 2002, Pages 113-119

  Firsov, Alexander A ^a,b   Zinner, Stephen H ^c   Vostrov, Sergey N ^a,b   Kononenko, Olga V ^a   Portnoy, Yury A ^a,b   Shustova, Larissa V ^a   Kadenatsi, Igor B ^a  

^a INSTITUTE OF BIOMEDICAL CHEMISTRY   (Russian Federation)

^b GAUSE INSTITUTE OF NEW ANTIBIOTICS   (Russian Federation)

^c HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AZITHROMYCIN; CIPROFLOXACIN; MACROLIDE; ROXITHROMYCIN;

ANTIBACTERIAL ACTIVITY; ARTICLE; BACTERIAL COUNT; BACTERIAL GROWTH; BACTERIUM ISOLATE; COMPARTMENT MODEL; CONTROLLED STUDY; DOSE TIME EFFECT RELATION; DRUG BLOOD LEVEL; DRUG PENETRATION; DRUG TISSUE LEVEL; GROWTH CURVE; IN VITRO STUDY; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; SIMULATION; STEADY STATE; STREPTOCOCCUS PNEUMONIAE; STREPTOCOCCUS PYOGENES; TONSIL;

EID: 0036151472     PISSN: 03057453     EISSN: None     Source Type: Journal    
DOI: 10.1093/jac/49.1.113     Document Type: Article

References (15)

1. Pharmacology
2. Azithromycin penetration into sinus mucosa and tonsillar tissue
3. The diffusion of clarithromycin and roxithromycin into nasal mucosa, tonsil and lung in humans
4. Determination of roxithromycin concentration in the mucosa of the maxillary sinus
5. Azithromycin: The first of the tissue-selective azalides
6. Comparative pharmacodynamics of clarithromycin and azithromycin against respiratory pathogens
7. Comparison of pharmacodynamics of azithromycin and erythromycin in vitro and in vivo
8. Concentrations of azithromycin in human tonsillar tissue
9. Validation of optimal ampicillin/sulbactam ratio in dosage forms using in-vitro dynamic model
10. Pharmacokinetic approaches to rational antibiotic therapy
11. Parameters of bacterial killing and regrowth kinetics and antimicrobial effect examined in terms of area under the concentration-time curve relationships: Action of ciprofloxacin against Escherichia coli in an in vitro dynamic model
12. Predictors of effect of ampicillin-sulbactam against TEM-1 β-lactamase-producing Escherichia coli in an in vitro dynamic model: Enzyme activity versus MIC
13. Tissue-directed pharmacokinetics
14. The role of newer macrolides in the treatment of community-acquired respiratory tract infections: A review of experimental and clinical data
15. Azithromycin. A review of its antimicrobial activity, pharmacokinetic properties and clinical efficacy