Human and Drosophila UDP-galactose transporters transport UDP-N-acetylgalactosamine in addition to UDP-galactose

European Journal of Biochemistry

Volumn 269, Issue 1, 2002, Pages 128-138

  Segawa, Hiroaki ^a,c   Kawakita, Masao ^a,b   Ishida, Nobuhiro ^a  

^a TOKYO METROPOLITAN INSTITUTE OF MEDICAL SCIENCE   (Japan)

^b KOGAKUIN UNIVERSITY   (Japan)

^c UNIVERSITY OF KENTUCKY MEDICAL CENTER   (United States)

Author keywords

Nucleotide sugar transporter; Site directed mutagenesis; UDP galactose; UDP galactose transporter; UDP N acetylgalactosamine

Indexed keywords

ALANINE; AMINO ACID; CARRIER PROTEIN; CYTIDINE PHOSPHATE; MUTANT PROTEIN; THREONINE; URIDINE DIPHOSPHATE GALACTOSE; URIDINE DIPHOSPHATE N ACETYLGALACTOSAMINE;

ARTICLE; CARBOHYDRATE TRANSPORT; CELL STRAIN; CELLULAR DISTRIBUTION; CONTROLLED STUDY; DROSOPHILA MELANOGASTER; GOLGI COMPLEX; MAMMAL CELL; MICROSOME; MOLECULAR RECOGNITION; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN STABILITY; PROTEIN STRUCTURE; SACCHAROMYCES CEREVISIAE; SEQUENCE HOMOLOGY; YEAST;

AMINO ACID SEQUENCE; ANIMALS; BASE SEQUENCE; BIOLOGICAL TRANSPORT; CLONING, MOLECULAR; DROSOPHILA MELANOGASTER; HUMANS; MOLECULAR SEQUENCE DATA; MONOSACCHARIDE TRANSPORT PROTEINS; MUTAGENESIS, SITE-DIRECTED; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTRATE SPECIFICITY; URIDINE DIPHOSPHATE GALACTOSE; URIDINE DIPHOSPHATE N-ACETYLGLUCOSAMINE;

DROSOPHILA MELANOGASTER; MAMMALIA; MELANOGASTER; MURINAE; SACCHAROMYCES; SACCHAROMYCES CEREVISIAE; SCHIZOSACCHAROMYCES POMBE; SIA;

EID: 0036151183     PISSN: 00142956     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.0014-2956.2001.02632.x     Document Type: Article

References (29)

1. Nucleotide sugar transporters: Elucidation of their molecular identity and its implication for future studies
2. Function and structure of Drosophila glycans
3. Three proteins involved in Caenorhabditis elegans vulval invagination are similar to components of a glycosylation pathway
4. Molecular cloning of the Golgi apparatus uridine diphosphate-N-acetyl-glucosamine transporter from Kluyveromyces lactis
5. The VRG4 gene is required for GDP-mannose transport into the lumen of the Golgi in the yeast, Saccharomyces cerevisiae
6. Schizosaccharomyces pombe UDP-galactose transporter: Identification of its functional form through cDNA cloning and expression in mammalian cells
7. Characterization of Yeast Yea4p, a uridine diphosphate-N-acetyl-glucosamine transporter localized in the endoplasmic reticulum and required for chitin synthesis
8. Golgi GDP-mannose uptake requires Leishmania LPG2: A member of a eukaryotic family of putative nucleotide-sugar transporters
9. sqv mutants of Caenorhabditis elegans are defective in vulval epithelial invagination
10. Human UDP-galactose translocator: Molecular cloning of a complementary DNA that complements the genetic defect of a mutant cell line deficient in UDP-galactose translocator
11. Molecular cloning and characterization of a novel isoform of the human UDP-galactose transporter, and of related complementary DNAs belonging to the nucleotide-sugar transporter gene family
12. Expression cloning of the Golgi CMP-sialic acid transporter
13. Molecular cloning of the hamster CMP-sialic acid transporter
14. Functional expression of human Golgi CMP-sialic acid transporter in the Golgi complex of a transporter-deficient Chinese hamster ovary cell mutant
15. Molecular cloning and functional expression of the human Golgi UDP-N-acetylglucosamine transporter
16. Molecular characterization of human UDP-glucuronic acid/UDP-N-acetylgalactosamine transporter, a novel nucleotide sugar transporter with dual substrate specificity
17. The 'megaprimer' method of site-directed mutagenesis
18. Transformation of intact yeast cells treated with alkali cations
19. Functional expression of the human UDP-galactose transporters in the yeast Saccharomyces cerevisiae
20. Expression of the human UDP-galactose transporter in the Golgi membranes of murine Had-1 cells that lack the endogenous transporter
21. Substrate recognition by UDP-galactose and CMP-sialic acid transporters: Different sets of transmembrane helices are utilized for the specific recognition of UDP-galactose and CMP-sialic acid
22. Transporters of nucleotide sugars, ATP, and nucleotide sulfate in the endoplasmic reticulum and Golgi apparatus
23. The Leishmania GDP-mannose transporter is an autonomous, multi-specific, hexameric complex of LPG2 subunits
24. Lectin histochemistry of the Drosophila embryo
25. Genetic evidence that heparin-like glycosaminoglycans are involved in wingless signaling
26. Use of dsRNA-mediated genetic interference to demonstrate that frizzled and frizzled 2 act in the wingless pathway
27. Membrane topology of the mammalian CMP-sialic acid transporter
28. Expression and activity of chimeric molecules between human UDP-galactose transporter and CMP-sialic acid transporter
29. A simple method for displaying the hydropathic character of a protein