Synthesis of [C2H3]methotrexate and [C2H3]7-hydroxymethotrexate

Journal of Labelled Compounds and Radiopharmaceuticals

Volumn 45, Issue 1, 2002, Pages 29-36

  Elmore, Charles S ^a   Dean, Dennis C ^a   Zhang, Yong ^a   Gibson, Carter ^a   Jenkins, Herb ^a   Jones, Allen N ^a   Melillo, David G ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

7 hydroxymethotrexate; Cyclooxygenase II; Methotrexate; Reductive amination; Rofecoxib

Indexed keywords

ALKYLATION; AMINATION; AMINES; SODIUM COMPOUNDS;

7-HYDROXYMETHOTREXATE; CYCLOOXYGENASE II; CYCLOOXYGENASES; INTERNAL STANDARDS; MASS INCREASE; METHOTREXATE; OH -; REDUCTIVE AMINATION; ROFECOXIB; STABLE ISOTOPES;

METHYLATION;

7 HYDROXYMETHOTREXATE; AMINOPTERIN; ANILINE; CARBROMAL; METHOTREXATE; ROFECOXIB; SILANE DERIVATIVE;

ALKYLATION; AMINATION; ARTICLE; DRUG STRUCTURE; DRUG SYNTHESIS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; METHYLATION; PURIFICATION; QUANTITATIVE ASSAY;

EID: 0036151055     PISSN: 03624803     EISSN: None     Source Type: Journal    
DOI: 10.1002/jlcr.537     Document Type: Article

References (10)

1. Chapter 60: Folate antagonists