Is there a genetic basis for resistance to atherosclerosis?

Atherosclerosis

Volumn 160, Issue 1, 2002, Pages 1-10

  Stein, Olga ^a   Thiery, Joachim ^b   Stein, Yechezkiel ^c  

^a HEBREW UNIVERSITY   (Israel)

^b UNIVERSITY HOSPITAL LEIPZIG   (Germany)

^c HADASSAH HEBREW UNIVERSITY MEDICAL CENTER   (Israel)

Author keywords

ABC; Apoprotein E; Hypercholesterolemia; LXR; Macrophages; Scavenger receptors

Indexed keywords

APOLIPOPROTEIN E; CHEMOKINE RECEPTOR CCR2; CHOLESTEROL; CHOLESTEROL ACYLTRANSFERASE; COLONY STIMULATING FACTOR 1; GENE PRODUCT; HIGH DENSITY LIPOPROTEIN; LOW DENSITY LIPOPROTEIN; MONOCYTE CHEMOTACTIC PROTEIN 1; SCAVENGER RECEPTOR; VASCULAR CELL ADHESION MOLECULE 1;

ATHEROGENESIS; ATHEROSCLEROSIS; CELL CULTURE; CHOLESTEROL BLOOD LEVEL; CHOLESTEROL INTAKE; CHOLESTEROL TRANSPORT; DIETARY INTAKE; FAMILIAL HYPERCHOLESTEROLEMIA; GENE CASSETTE; HUMAN; INTESTINE ABSORPTION; LIFESPAN; LIVER; MACROPHAGE; MULTIGENE FAMILY; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; REVIEW;

ANIMALS; ANTIGENS, CD36; APOLIPOPROTEINS E; ARTERIOSCLEROSIS; CARRIER PROTEINS; CHEMOKINE CCL2; CHOLESTEROL; CHOLESTEROL, DIETARY; CORONARY DISEASE; DNA-BINDING PROTEINS; GENE EXPRESSION REGULATION; GENETIC MARKERS; GENETIC PREDISPOSITION TO DISEASE; HUMANS; HYPERCHOLESTEROLEMIA; MACROPHAGE COLONY-STIMULATING FACTOR; MEMBRANE PROTEINS; RECEPTORS, CHEMOKINE; RECEPTORS, CYTOPLASMIC AND NUCLEAR; RECEPTORS, IMMUNOLOGIC; RECEPTORS, LIPOPROTEIN; RECEPTORS, RETINOIC ACID; RECEPTORS, SCAVENGER; RECEPTORS, THYROID HORMONE; SCAVENGER RECEPTORS, CLASS B; STEROL O-ACYLTRANSFERASE; VASCULAR CELL ADHESION MOLECULE-1; VASCULAR RESISTANCE;

EID: 0036147481     PISSN: 00219150     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0021-9150(01)00664-5     Document Type: Review

References (112)

1. Alternative projections of mortality and disability by cause 1990-2020: Global Burden of Disease Study
2. The influence of dietary fats on serum-lipid levels in man
3. Variability in individual serum cholesterol response to change in diet
4. Existence of resistent hypo- and hyperresponders to dietary cholesterol in man
5. Hypo- and hyperresponders: Individual differences in the response of serum cholesterol concentration to changes in diet
6. Congruence of individual responsiveness to dietary cholesterol and to saturated fat in humans
7. Individual responses to a cholesterol-lowering diet in 50 men with moderate hypercholesterolemia
8. Efficacy of a National Cholesterol Education Program Step 2 diet in normolipidemic and hypercholesterolemic middle-aged and elderly men and women
9. Cholesterol absorption and synthesis related to low density lipoprotein metabolism during varying cholesterol intake in men with different apoE phenotypes
10. Effect of apolipoprotein E phenotype on diet-induced lowering of plasma low density lipoprotein cholesterol
11. Apolipoprotein E alleles and risk of coronary disease. A meta-analysis
12. Apolipoprotein E genotype and cardiovascular disease in the Framingham Heart Study
13. ApoA-IV phenotype affects diet-induced plasma LDL cholesterol lowering
14. Genetic determinants of plasma lipid response to dietary intervention: The role of the APOA1/C3/A4 gene cluster and the APOE gene
15. Regulation of absorption and ABC1 mediated efflux of cholesterol by RXR heterodimers
16. Regulation of the cholesterol efflux gene, ABCA1
17. Mutations in ABC1 in Tangier disease and familial high-density lipoprotein deficiency
18. The gene encoding ATP-binding cassette transporter 1 is mutated in Tangier disease
19. Tangier disease is caused by mutations in the gene encoding ATP-binding cassette transporter 1
20. ABC1 gene expression and apoA-I-mediated cholesterol efflux are regulated by LXR
21. Accumulation of dietary cholesterol in sitosterolemia caused by mutations in adjacent ABC transporters
22. The correlation of ATP-binding cassette 1 mRNA levels with cholesterol efflux from various cell lines
23. Localization of human ATP-binding cassette transporter 1 (ABC1) in normal and atherosclerotic tissues
24. Normal plasma cholesterol in an 88-year-old man who eats 25 eggs a day: Mechanism of adaptation
25. Relationships between dietary cholesterol, cholesterol absorption, cholesterol synthesis, and plasma cholesterol in rhesus monkeys
26. Development and partial metabolic characterization of a dietary cholesterol-resistant colony of rabbits
27. Dietary cholesterol absorption, and sterol and bile acid excretion in hypercholesterolemia-resistant white rabbits
28. Sterol balance and cholesterol absorption in inbred strains of rabbits hypo- or hyperresponsive to dietary cholesterol
29. Effect of sucrose polyester on plasma lipids and cholesterol absorption in African green monkeys with variable hypercholesterolemic response to dietary cholesterol
30. Identification of a metabolic difference accounting for the hyper- and hyporesponder phenotypes of cynomolgus monkey
31. Hyper- and hypo-responsiveness to dietary fat and cholesterol among inbred mice: Searching for level and variability genes
32. Biliary cholesterol excretion: A novel mechanism that regulates dietary cholesterol absorption
33. Hepatic cholesterol and bile acid metabolism and intestinal cholesterol absorption in scavenger receptor class B type I-deficient mice
34. Apolipoprotein E regulates dietary cholesterol absorption and biliary cholesterol excretion: Studies in C57BL/6 apolipoprotein E knockout mice
35. Genetic differences in cholesterol absorption in 129/Sv and C57BL/6 mice: Effect on cholesterol responsiveness
36. A locus conferring resistance to diet-induced hypercholesterolemia and atherosclerosis on mouse chromosome 2
37. Resistance to diet-induced hypercholesterolemia and gallstone formation in ACAT2-deficient mice
38. Familial hypercholesterolemia
39. Coronary disease in familial hypercholesterolemia
40. Risks of ischaemic heart disease in familial hyperlipo-proteinaemic states
41. The risk of atherosclerotic vascular disease in subjects with xanthomatosis
42. Coronary artery disease in 116 kindreds with famlial type II hyperlipoproteinemia
43. Ischaemic disease in men and women with familial hypercholesterolaemia and xanthomatosis. A comparative study of genetic and environmental factors in 274 heterozygous cases
44. Essential familial hypercholesterolemia and xanthomatosis
45. Evidence that men with familial hypercholesterolemia can avoid early coronary death. An analysis of 77 gene carriers in four Utah pedigrees
46. The risk of atherosclerotic vascular disease in subjects with xanthomatosis
47. Intrafamilial variability in the clinical expression of familial hypercholesterolemia: Importance of risk factor determination for genetic counselling
48. Characteristic features of long-living patients with familial hypercholesterolemia in Japan
49. A host of hypercholesterolaemic homozygotes in South Africa
50. Experiences with the homozygous cases of familial hypercholesterolemia. A report of 52 patients
51. Familial defective apolipoprotein B-100: Detection in the United Kingdom and Scandinavia, and clinical characteristics of ten cases
52. Familial defective apolipoprotein B-100: Comparison with familial hypercholesterolemia in 18 cases detected in Munich
53. Clinical signs of familial hypercholesterolemia in patients with familial defective apolipoprotein B-100 and normal low density lipoprotein receptor function
54. Evidence for a dominant gene that suppresses hypercholesterolemia in a family with defective low density lipoprotein receptors
55. Evidence for a cholesterol-lowering gene in a French-Canadian kindred with familial hypercholesterolemia
56. Familial lipoprotein disorders in patients with premature coronary artery disease
57. Atherosclerosis susceptibility differences among progenitors of recombinant inbred strains of mice
58. Quantitative assessment of atherosclerotic lesions in mice
59. Genetics of responsiveness to high-fat and high-cholesterol diets in the mouse
60. Phenotypic characterization of the Ath-1 gene controlling high density lipoprotein levels and susceptibility to atherosclerosis
61. Complex genetic control of HDL levels in mice in response to an atherogenic diet: Coordinate regulation of HDL levels and bile acid metabolism
62. Macrophage cholesterol metabolism, apolipoprotein E, and scavenger receptor AI/II mRNA in atherosclerosis-susceptible and -resistant mice
63. High density lipoprotein metabolism
64. Atheroprotective mechanisms of HDL
65. Cholesterol efflux in vivo from a depot of cationized LDL injected into a thigh muscle of small rodents
66. Effect of atherogenic diet on reverse cholesterol transport in vivo in atherosclerosis susceptible (C57BL/6) and resistant (C3H) mice
67. Effect of dietary cholesterol and taurocholate on cholesterol 7 alpha-hydroxylase and hepatic LDL receptors in inbred mice
68. Genetic control of inflammatory gene induction and NF-kappa B-like transcription factor activation in response to an atherogenic diet in mice
69. Complex genetic control of HDL levels in mice in response to an atherogenic diet. Coordinate regulation of HDL levels and bile acid metabolism
70. Endothelial response to oxidized lipoproteins determine genetic susceptibility to atherosclerosis in mice
71. Determinants of atherosclerosis susceptibility in the C3H and C57BL/6 mouse model. Evidence for involvement of endothelial cells but not blood cells or cholesterol metabolism
72. Genetic susceptibility to atherosclerosis. Insights from mice
73. Genetic background determines the extent of atherosclerosis in ApoE-deficient mice
74. High density lipoproteins and arteriosclerosis. Role of cholesterol efflux and reverse cholesterol transport
75. Influence of age on the metabolism of plasma low density lipoproteins in healthy males
76. Lipoprotein receptors and cholesterol homeostasis
77. Age-related changes in the metabolism of acetylated low-density lipoproteins by peritoneal macrophages from C57BL/6CrScl mice
78. Scavenger receptor activity and expression of apolipoprotein E mRNA in monocyte-derived macrophages of young and old healthy men
79. In hypercholesterolemia, lower peripheral monocyte count is unique among the major predictors of atherosclerosis
80. Low atherosclerotic response of a strain of rabbits to diet-induced hypercholesterolemia
81. Study of causes underlying the low atherosclerotic response to dietary hypercholesterolemia in a selected strain of rabbits
82. Expression of vascular cell adhesion molecule-1 (VCAM-1) in the aortae of hypercholesterolemic rabbits with high (HAR) and low (LAR) atherosclerotic response
83. Scavenger receptor activity is increased in macrophages from rabbits with low atherosclerosis response: Studies in normocholesterolemic high and low atherosclerotic response rabbits
84. Scavenger receptors in atherosclerosis. New answers, new questions
85. Scavenging new insights into atherogenesis
86. Recent progress in defining role of scavenger receptors in lipid transport, atherosclerosis and host defence
87. Reduced atherosclerotic lesions in mice deficient for total or macrophage-specific expression of scavenger receptor-A
88. Scavenger receptor deficiency leads to more complex atherosclerotic lesions in APOE3Leiden transgenic mice
89. Effect of human scavenger receptor class A overexpression in bone marrow-derived cells on cholesterol levels and atherosclerosis in apoE-deficient mice
90. Effect of human scavenger receptor class A overexpression in bone marrow-derived cells on lipoprotein metabolism and atherosclerosis in low density lipoprotein receptor knockout mice
91. The binding of oxidized low density lipoprotein to mouse CD36 is mediated by phospholipids that are associated with both the lipid and protein moieties
92. Different patterns of 1231-BMIPP myocardial accumulation in patients with type I and II CD36 deficiency
93. Targeted disruption of the class B scavenger receptor, CD36, protects against atherosclerotic lesion development in mice
94. Peroxisone proliferator-activated receptor γ ligands inhibit development of atherosclerosis in LDL receptor-deficient mice
95. Troglitazone inhibits formation of early atherosclerotic lesions in diabetic and nondiabetic low density lipoprotein receptor-deficient mice
96. CLA-1/SR-BI is expressed in atherosclerotic lesion macrophages and regulated by activators of peroxisome proliferator-activated receptors
97. Identification of scavenger receptor SR-BI as a high density lipoprotein receptor
98. Scavenger receptor B1 promotes high density lipoprotein-mediated cellular cholesterol efflux
99. Decreased atherosclerosis in mice deficient in both macrophage colony-stimulating factor (op) and apolipoprotein E
100. Heterozygous osteopetrotic (op) mutation reduces atherosclerosis in LDL receptor-deficient mice
101. Absence of monocyte chemoattractant protein-1 reduced atherosclerosis in low density receptor-deficient mice
102. -/- mice reveals a role for chemokines in the initiation of atherosclerosis
103. MCP-1 deficiency reduces susceptibility to atherosclerosis in mice that overexpress human apolipoprotein B
104. Reduction of atherosclerosis despite hypercholesterolemia in lyn-deficient mice fed a high-fat diet
105. Prevention of atherosclerosis in apolipoprotein E-deficient mice by bone marrow transplantation
106. Treatment of severe hypercholesterolemia in apolipoprotein E-deficient mice by bone marrow transplantation
107. Bone marrow transplantation in apolipoprotein E-deficient mice. Effect of ApoE gene dosage on serum lipid concentrations, (beta)VLDL catabolism, and atherosclerosis
108. Macrophage-specific expression of human apoprotein E reduces atherosclerosis in hypercholesterolemic apolipoprotein E-null mice
109. Hepatic expression of apolipoprotein E inhibits progression of atherosclerosis without reducing cholesterol levels in LDL receptor-deficient mice
110. Apolipoprotein E prevents the progression of atherosclerosis in Watanabe heritable rabbits
111. Low levels of extrahepatic nonmacrophage apoE inhibit atherosclerosis without correcting hypercholesterolemia in apoE-deficient mice
112. Synthetic low and high fat diets for the study of atherosclerosis in the mouse