Inhibitors of fibrinolytic components play different roles in the formation and removal of arterial thrombus in mice

Journal of Cardiovascular Pharmacology

Volumn 39, Issue 2, 2002, Pages 278-286

  Matsuno, Hiroyuki ^a   Kozawa, Osamu ^a   Okada, Kiyotaka ^a   Ueshima, Shigeru ^a   Matsuo, Osamu ^a   Uematsu, Toshihiko ^a  

^a GIFU UNIVERSITY   (Japan)

Author keywords

2 Anti plasmin; Gene inactived mice; Plasminogen activator inhibitor 1; Reperfusion; Thrombus

Indexed keywords

ANTIPLASMIN; PLASMINOGEN ACTIVATOR INHIBITOR; THROMBIN INHIBITOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTERY THROMBOSIS; ARTICLE; BLOOD CLOT LYSIS; CONTROLLED STUDY; DRUG EFFECT; ENDOTHELIUM INJURY; FIBRINOLYSIS; GENE INACTIVATION; GRAFT PATENCY; MOUSE; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; REPERFUSION;

ANIMALS; ANTIPLASMIN; BLEEDING TIME; BLOOD COAGULATION; CAROTID ARTERY INJURIES; ENDOTHELIUM, VASCULAR; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; PIPECOLIC ACIDS; PIPERAZINES; PIPERIDINES; PLASMINOGEN ACTIVATOR INHIBITOR 1; PLATELET AGGREGATION; PLATELET AGGREGATION INHIBITORS; PLATELET GLYCOPROTEIN GPIIB-IIIA COMPLEX; SERINE PROTEINASE INHIBITORS; THROMBIN; THROMBIN TIME; THROMBOSIS; VASCULAR PATENCY;

EID: 0036146626     PISSN: 01602446     EISSN: None     Source Type: Journal    
DOI: 10.1097/00005344-200202000-00015     Document Type: Article

References (32)

1. Basic and clinical aspects of fibrinolysis and thrombolysis
2. Purification of a protein from bovine plasma that binds to type 1 plasminogen activator inhibitor and prevents its interaction with extracellular matrix: Evidence that the protein is vitronectin
3. Regulation of fibrinolysis by platelet-released plasminogen activator inhibitor 1: Light scattering and ultrastructural examination of lysis of a model platelet-fibrin thrombus
4. Inhibition of plasminogen activator inhibitor-1 activity results in promotion of endogenous thrombolysis and inhibition of thrombus extension in models of experimental thrombosis
5. Plasminogen activator inhibitor-1 released from activated platelets plays a key role in thrombolysis resistance: Studies with thrombi generated in the Chandler loop
6. Plasminogen activator inhibitor (PAI-1) in plasma and platelets
7. Proteins of the fibrinolytic system in human thrombi
8. Attenuation of thrombolysis by release of plasminogen activator inhibitor type-1 from platelets
9. Differential role of components of the fibrinolytic system in the formation and removal of thrombus induced by endothelial injury
10. Plasminogen activator inhibitor-1 is a major determinant of arterial thrombolysis resistance
11. Identification and some properties of a new fast-reacting plasmin inhibitor in human plasma
12. On the mechanism of the reaction between human alpha 2-antiplasmin and plasmin
13. Elevated levels of plasmin-alpha2 antiplasmin complexes in unstable angina
14. Photochemically induced thrombosis model in rat femoral artery and evaluation of effects of heparin and tissue-type plasminogen activator with use of this model
15. Effects of vapiprost, a novel thromboxane receptor antagonist, on thrombus formation and vascular patency after thrombolysis by tissue-type plasminogen activator
16. A comparative study of the antithrombotic effect of aurintricarboxylic acid on arterial thrombosis in rats and guinea pigs
17. Lack of tPA significantly affects antithrombotic therapy by a GPIIb/IIIa antagonist, but not by a thrombin inhibitor in mice
18. Inhibition of integrin function by a cyclic RGD-containing peptide prevents neointima formation
19. Plasminogen activator inhibitor-1 gene-deficient mice: I: Generation by homologous recombination and characterization
20. Characterization and targeting of the murine alpha2-antiplasmin gene
21. Plasminogen activator inhibitor-1 gene-deficient mice: II: Effects on hemostasis, thrombosis, and thrombolysis
22. Physiological consequences of loss of plasminogen activator gene function in mice
23. Long-term prognosis of late spontaneous reperfusion after failed thrombolysis for acute myocardial infarction
24. Spontaneous reperfusion after ischemic stroke is associated with improved outcome
25. Both circulating and clot-bound plasminogen activator inhibitor-1 inhibit endogenous fibrinolysis in the rat
26. Suppression of thrombolysis in a canine model of pulmonary embolism
27. Characterization of wild-type and mutant alpha2-antiplasmins: Fibrinolysis enhancement by reactive site mutant
28. Vascular release of plasminogen activator inhibitor-1 impairs fibrinolysis during acute arterial thrombosis in mice
29. Comparison of the antithrombotic effects and bleeding risk of fractionated aurin tricarboxylic acid and the GPIIb/IIIa antagonist GR144053 in a hamster model of stenosis
30. T-686, a novel inhibitor of plasminogen activator inhibitor-1, inhibits thrombosis without impairment of hemostasis in rats
31. Thrombolysis and reocclusion in experimental jugular vein and coronary artery thrombosis: Effects of a plasminogen activator inhibitor type 1-neutralizing monoclonal antibody
32. Induction of plasminogen activator inhibitor by products released from platelets