Functional coupling of rat metabotropic glutamate 1a receptors to phospholipase D in CHO cells: Involvement of extracellular Ca2+, protein kinase C, tyrosine kinase and Rho-A

Neuropharmacology

Volumn 42, Issue 1, 2002, Pages 1-8

  Kanumilli, S ^a   Toms, N J ^b   Venkateswarlu, K ^a   Mellor, H ^a   Roberts, P J ^a  

^a UNIVERSITY OF BRISTOL   (United Kingdom)

^b UNIVERSITY OF SURREY   (United Kingdom)

Author keywords

Calcium; Metabotropic glutamate receptor; Phospholipase D; Protein kinase C; Small G proteins; Tyrosine kinase

Indexed keywords

1 AMINO 1,3 CYCLOPENTANEDICARBOXYLIC ACID; 2 [1 (3 DIMETHYLAMINOPROPYL) 3 INDOLYL] 3 (3 INDOLYL)MALEIMIDE; 3,5 DIHYDROXYPHENYLGLYCINE; ADENOSINE DIPHOSPHATE RIBOSYLATION FACTOR; ALPHA METHYL 4 CARBOXYPHENYLGLYCINE; BREFELDIN A; CALCIUM ION; EXOENZYME C3; GENISTEIN; GLUTAMATE RECEPTOR AGONIST; GLUTAMATE RECEPTOR ANTAGONIST; GLUTAMIC ACID; LANTHANUM; METABOTROPIC RECEPTOR; MUTANT PROTEIN; PHOSPHOLIPASE D; PROTEIN INHIBITOR; PROTEIN KINASE C; PROTEIN KINASE C INHIBITOR; PROTEIN TYROSINE KINASE; PROTEIN TYROSINE KINASE INHIBITOR; QUISQUALIC ACID; RHO GUANINE NUCLEOTIDE BINDING PROTEIN; UNCLASSIFIED DRUG; ZINC;

ANIMAL CELL; ARTICLE; CALCIUM CELL LEVEL; CALCIUM TRANSPORT; CHO CELL; COMPARATIVE STUDY; CONTROLLED STUDY; DRUG EFFECT; DRUG POTENCY; DRUG SELECTIVITY; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME REGULATION; EXTRACELLULAR CALCIUM; GENE CONSTRUCT; GENETIC TRANSFECTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION;

ANIMALS; CALCIUM; CHO CELLS; CRICETINAE; DOWN-REGULATION; EXCITATORY AMINO ACID ANTAGONISTS; EXTRACELLULAR SPACE; GTP-BINDING PROTEINS; PHOSPHOLIPASE D; PROTEIN KINASE C; PROTEIN-TYROSINE KINASES; RATS; RECEPTORS, METABOTROPIC GLUTAMATE; RHOA GTP-BINDING PROTEIN; TRANSFECTION;

EID: 0036144253     PISSN: 00283908     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0028-3908(01)00161-7     Document Type: Article

References (43)

1. 2+ signal transduction
2. Antagonist pharmacology of metabotropic glutamate receptors coupled to phospholipase D activation in adult rat hippocampus: Focus on (2R,1′S,2′R,3′S)-2-(2′-carboxy-3′- phenylcyclopropyl)glycine versus 3,5-dihydroxyphenylglycine
3. Signal transduction and pharmacological characteristics of a metabotropic glutamate receptor, mGluR1, in transfected CHO cells
4. Metabotropic glutamate receptor mGluR5 in astrocytes: Pharmacological properties and agonist regulation
5. Aroleror philospolipase D in the control of mitogenesis
6. 2+ and protein kinase C in receptor mediated phospholipase D activation in Chinese hamster ovary cells expressing the cholecystokinin-A receptor
7. Metabotropic excitatory amino acid receptor activation stimulates phospholipase D in hippocampal slices
8. L-Cysteine sulfinic acid as an endogenous agonist of a novel metabotropic receptor coupled to stimulation of phospholipase D activity
9. ADP-ribosylation factor, a small GTP-dependent regulatory protein, stimulates phospholipase D activity
10. Opposite influence of the metabotropic glutamate receptor subtypes mGlu3 and -5 on astrocyte proliferation in culture
11. The regulation of phospholipase D activity and its role in sn-1,2-diradylglycerol formation in bombesin- and phorbol 12-myristate 13-acetate-stimulated Swiss 3T3 cells
12. Pharmacology and functions of metabotropic glutamate receptors
13. Regulation of phospholipase D
14. 2+ channels by two different mechanisms
15. Glutamate activates phospholipase D in hippocampal slices of newborn and adult rats
16. Regulation of phospholipase D by phosphorylation-dependent mechanisms
17. Muscarinic receptor-stimulated cytosol-membrane translocation of Rho-A
18. Ontogenetic and pharmacological studies on metabotropic glutamate receptors coupled to phospholipase D activation
19. Glutamatergic activation of hippocampal phospholipase D: Postnatal fading and receptor desensitization
20. Ethanol inhibits astroglial cell proliferation by disruption of phospholipase D-mediated signalling
21. Activation of astroglial phospholipase D activity by phorbol ester involves ARF and Rho proteins
22. 2+-sensing function of the metabotropic glutamate receptors
23. The roles of protein kinase C and tyrosine kinases in mediating endothelin-1-stimulated phospholipase D activity in rat myometrium: Differential inhibition by ceramides and cyclic AMP
24. Activation of phospholipase D in Chinese hamster ovary cells expressing platelet-activating factor receptor
25. PLD activation in Chinese hamster ovary (CHO) cells transfected with PGF2 receptor cDNA
26. Differential regulation of phospholipases C and D by phorbol esters and the physiological activators carbachol and glutamate in astrocytes from chicken embryo cerebrum and cerebellum
27. PRK1 is targeted to endosomes by the small GTPase, RhoB
28. Molecular biology of glutamate receptors in the central nervous system and their role in excitotoxicity, oxidative stress and aging
29. Rhodopsin-family receptors associate with small G proteins to activate phospholipase D
30. Store depletion and calcium influx
31. (+)-MCPG induces PKC translocation in cortical synaptosomes through a PLD-coupled mGluR
32. Pharmacological characterization of metabotropic glutamate receptors coupled to phospholipase D in the rat hippocampus
33. Purinergic and muscarinic receptor activation activates a common calcium entry pathway in rat neocortical neurons and glial cells
34. Tyrosine-phosphorylation-dependent and Rho-protein-mediated control of cellular phosphatidylinositol 4,5-bisphosphate levels
35. 1 and endothelin ETB receptors mediate phospholipase D stimulation in rat brain hippocampal slices
36. 2+ on type 1alpha metabotropic glutamate receptor-mediated signalling
37. A role for Rho-kinase in Rho-controlled phospholipase D stimulation by the M3 muscarinic acetylcholine receptor
38. Group I metabotropic glutamate receptors mediate phospholipase D stimulation in rat cultured astrocytes
39. Activation of phospholipase D by metabotropic glutamate receptor agonists in rat cerebrocortical synaptosomes
40. Functional coupling of the NK1 tachykinin receptor to phospholipase D in Chinese hamster ovary cells and astrocytoma cells
41. The bisindolylmaleimide GF 109203X is a potent and selective inhibitor of protein kinase C
42. Interaction of the small G protein RhoA with the C terminus of human phospholipase D1
43. Dependence of intracellular signaling and neurosecretion on phospholipase D activation in immortalized gonadotropin-releasing hormone neurons