Biallelic inactivation of the von Hippel-Lindau tumor suppressor gene in sporadic renal cell carcinoma

Journal of Urology

Volumn 167, Issue 2 I, 2002, Pages 713-717

  Hamano, Kiminari ^a   Esumi, Mariko ^a   Igarashi, Hiroshi ^a   Chino, Kenji ^a   Mochida, Jun'Ichi ^a   Ishida, Hajime ^a   Okada, Kiyoki ^a  

^a NIHON UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Carcinoma, renal cell; Genes, suppressor tumor; Hippel Lindau disease; Kidney; Loss of heterozygosity

Indexed keywords

AMINO ACID; MICROSATELLITE DNA;

ALLELE; ARTICLE; CARCINOGENESIS; CHROMOSOME 3P; DNA EXTRACTION; DNA METHYLATION; DNA SEQUENCE; FRAMESHIFT MUTATION; GENE INACTIVATION; GENE LOCUS; HETEROZYGOSITY LOSS; HUMAN; HUMAN TISSUE; JAPAN; KIDNEY CARCINOMA; MAJOR CLINICAL STUDY; NUCLEOTIDE REPEAT; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; SEQUENCE ANALYSIS; SINGLE NUCLEOTIDE POLYMORPHISM; SOMATIC MUTATION; TUMOR SUPPRESSOR GENE; VON HIPPEL LINDAU DISEASE; VON HIPPEL LINDAU TUMOR SUPPRESSOR GENE;

EID: 0036143370     PISSN: 00225347     EISSN: None     Source Type: Journal    
DOI: 10.1097/00005392-200202000-00071     Document Type: Article

References (27)

1. A detailed deletion mapping of the short arm of chromosome 3 in sporadic renal cell carcinoma
2. Terminal deletion of chromosome 3p sequences in nonpapillary renal cell carcinomas: A breakpoint cluster between loci D3S1285 and D3S1603
3. The FHIT gene, scanning the chromosome 3p14.2 fragile site and renal carcinoma-associated t(3;8) breakpoint, is abnormal in digestive tract cancers
4. Identification of the von Hippel-Lindau disease tumor suppressor gene
5. Characteristic loss of heterozygosity in chromosome 3P and low frequency of replication errors in sporadic renal cell carcinoma
6. Mutations of the VHL tumour suppressor gene in renal carcinoma
7. Frequent somatic mutations and loss of heterozygosity of the von Hippel-Lindau tumor suppressor gene in primary human renal cell carcinomas
8. DNA methylation errors and cancer
9. A PCR generated AccI RFLP in the 3′ untranslated region of the von Hippel-Lindau disease (VHL) tumour suppressor gene
10. Mutations of the VHL gene in sporadic renal cell carcinoma: Definition of a risk factor for VHL patients to develop an RCC
11. Molecular analysis of the von Hippel-Lindau disease tumor suppressor gene in human lung cancer cell lines
12. Methylation-specific PCR: A novel PCR assay for methylation status of CpG islands
13. VHL alterations in human clear cell renal cell carcinoma: Association with advanced tumor stage and a novel hot spot mutation
14. Inactivation of the von Hippel-Lindau (VHL) tumour suppressor gene and allelic losses at chromosome arm 3p in primary renal cell carcinoma: Evidence for a VHL-independent pathway in clear cell renal tumourigenesis
15. Silencing of the VHL tumor-suppressor gene by DNA methylation in renal carcinoma
16. Inhibition of transcription elongation by the VHL tumor suppressor protein
17. Rbx1, a component of the VHL tumor suppressor complex and SCF ubiquitin ligase
18. Ubiquitination of hypoxia-inducible factor requires direct binding to the beta-domain of the von Hippel-Lindau protein
19. The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis
20. The von Hippel-Lindau tumor suppressor protein is required for proper assembly of an extracellular fibronectin matrix
21. The von Hippel-Lindau tumor suppressor gene is required for cell cycle exit upon serum withdrawal
22. The von Hippel-Lindau gene product inhibits vascular permeability factor/vascular endothelial growth factor expression in renal cell carcinoma by blocking protein kinase C pathways
23. Inhibition of insulin-like growth factor-I-mediated cell signaling by the von Hippel-Lindau gene product in renal cancer
24. Activation of Sp1-mediated vascular permeability factor/vascular endothelial growth factor transcription requires specific interaction with protein kinase C zeta
25. An important von Hippel-Lindau tumor suppressor domain mediates Sp1-binding and self-association
26. Genomic organization and chromosomal localization of the human CUL2 gene and the role of von Hippel-Lindau tumor suppressor-binding protein (CUL2 and VBP1) mutation and loss in renal-cell carcinoma development