Detection of genetic alterations in the p53 suppressor gene and the K-ras oncogene among different grades of dysplasia in patients with colorectal adenomas

Cancer

Volumn 94, Issue 1, 2002, Pages 219-227

  Hosaka, Shigetoshi ^a   Aoki, Yuji ^a   Akamatsu, Taiji ^a   Nakamura, Naoshi ^a   Hosaka, Noriko ^a   Kiyosawa, Kendo ^a  

^a SHINSHU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Colorectal adenomas; High grade dysplasia; K ras gene mutations; Low grade dysplasia; p53 gene mutations; p53 protein expression,

Indexed keywords

PROTEIN P53;

ADULT; AGED; ARTICLE; COLON ADENOMA; COLON CARCINOGENESIS; COLORECTAL TUMOR; DYSPLASIA; FEMALE; GENE MUTATION; GENE SEQUENCE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; MAJOR CLINICAL STUDY; MALE; ONCOGENE K RAS; PRIORITY JOURNAL; PROTEIN EXPRESSION; SCORING SYSTEM; SUPPRESSOR GENE;

ADENOMA; ADULT; AGED; AGED, 80 AND OVER; COLORECTAL NEOPLASMS; FEMALE; GENES, P53; GENES, RAS; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; MIDDLE AGED; MUTATION; POLYMERASE CHAIN REACTION; TUMOR SUPPRESSOR PROTEIN P53;

EID: 0036142361     PISSN: 0008543X     EISSN: None     Source Type: Journal    
DOI: 10.1002/cncr.10198     Document Type: Article

References (33)

1. Genetic alterations during colorectal-tumor development
2. A genetic model for colorectal tumorigenesis
3. Clinical implications of the p53 tumor-suppressor gene
4. Mutations in the p53 tumor suppressor gene: Clues to cancer etiology and molecular pathogenesis
5. p53 gene mutations occur in combination with 17p allelic deletions as late events in colorectal tumorigenesis
6. p53 mutations in colorectal cancer
7. Loss of heterozygosity of p53 gene and p53 protein expression in human colorectal carcinomas
8. Expression of p53 and 17p allelic loss in colorectal carcinoma
9. Expression of the nuclear oncogene p53 in colon tumours
10. p53 expression in colorectai tumors
11. Over-expression of p53 nuclear oncoprotein in colorectal adenomas
12. Immunohistochemical study of p53 expression in microwave-fixed, paraffin-embedded sections of colorectal carcinoma and adenoma
13. p53 expression in colorectal adenomas
14. Immunohistochemical analysis of p53 overexpression in human colonic tumors
15. Overexpression of p53 protein and proliferative activity in colorectal adenoma
16. p53 protein expression in colorectal adenomas: An immunohistochemical study using an antigen retrieval system
17. Expression of bcl-2 and in de novo and ex-adenoma colon carcinoma: A comparative immunohistochemical study
18. p53 protein immunohistochemical expression in colonic adenomas with and without associated carcinoma
19. Prevalence of rasgene mutations in human colorectal cancers
20. Detection of high incidence of K-ras oncogenes during human colon tumorigenesis
21. Genetic events in sporadic colorectal adenomas: K-ras and p53 heterozygous mutations are not sufficient for malignant progression
22. High frequency of K-ras mutations in sporadic colorectal adenomas
23. P53 expression and K-ras mutation in colorectal adenomas
24. K-ras gene mutation related to histological atypias in human colorectal adenomas
25. K-ras mutations in adenomas: A characteristic of cancer-bearing colorectal mucosa
26. K-RAS-2 gene mutations as predictors of metachronous colorectal adenomas
27. Genetic heterogeneity in sporadic colorectal adenomas
28. Genetic epidemiology of mutated K-ras proto-oncogene, altered suppressor genes, and microsatellite instability in colorectal adenomas
29. Activation of c-K-ras mutations in human gastrointestinal tumors
30. The national polyp study: Patient and polyp characteristics associated with high-grade dysplasia in colorectal adenomas
31. bcl-2 and p53 oncoprotein expression during colorectal tumorigenesis
32. Reassessment of K-ras mutations at codon 12 by direct PCR and sequencing from tissue microdissection in human pancreatic adenocarcinomas