A new approach to model reduction for complex physiologically based drug models

Control Engineering Practice

Volumn 10, Issue 1, 2002, Pages 67-81

  Mahfouf, M ^a   Linkens, D A ^a   Xue, D ^a  

^a UNIVERSITY OF SHEFFIELD   (United Kingdom)

Author keywords

Anaesthetic; Balanced realisation; Model reduction; Pharmacodynamics; Pharmacokinetics; Physiological modelling; Predictive control

Indexed keywords

CONCENTRATION (PROCESS); DIFFERENTIAL EQUATIONS; PHYSIOLOGY; TRANSFER FUNCTIONS;

ALGEBRAIC EQUATIONS;

DRUG DOSAGE;

CONTROL; MEDICAL APPLICATION;

EID: 0036141214     PISSN: 09670661     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0967-0661(01)00131-9     Document Type: Article

References (20)

1. Generalised predictive control-Part I and II
2. A physiological model for the distribution of injected agents with special reference to pethedine
3. Understanding pharmacokinetics and pharmacodynamics through computer simulation: I. The comparative clinical profiles of fentanyl and alfentanil
4. Algorithm to control effect compartment drug concentrations in pharmacokinetic model- driven drug delivery
5. Physiological pharmacokinetic models-a review of their principles and development
6. A comparative study of flow-limited and diffusion-limited physiological models for fentanyl in humans
7. Model reduction for complex physiologically based drug models
8. Circulation-time models of the uptake of inhaled anaesthetics and data for quantifying them
9. Principal component analysis in linear systems: Controllability, observability, and model reduction
10. Total intravenous anaesthesia with propofol and alfentanil by computer assisted infusion
11. Pharmacokinetics and pharmacodynamics- evolution of current concepts
12. A PC-based graphical simulator for physiological pharmacokinetic models
13. Intravenous propofol anaesthesia using a computerized infusion system
14. Negative power functions of time in pharmacokinetics and their applications