The toxin Tx4(6-1) from the spider Phoneutria nigriventer slows down NA+ current inactivation in insect CNS via binding to receptor site 3

Journal of Insect Physiology

Volumn 48, Issue 1, 2002, Pages 53-61

  De Lima, M E ^a   Stankiewicz, M ^b   Hamon, A ^c   De Figueiredo, S G ^d   Cordeiro, M N ^e   Diniz, C R ^e   Martin Eauclaire, M F ^f   Pelhate, M ^c  

^a FEDERAL UNIVERSITY OF MINAS GERAIS   (Brazil)

^b NICOLAUS COPERNICUS UNIVERSITY   (Poland)

^c UNIVERSITÉ D'ANGERS   (France)

^d FEDERAL UNIVERSITY OF ESPÍRITO SANTO   (Brazil)

^e FUNDAÇÃO EZEQUIEL DIAS   (Brazil)

^f CNRS   (France)

Author keywords

Insect; Neurotoxin; Sodium channel; Spider; Toxin

Indexed keywords

ALPHA TOXIN; NEUROTOXIN; RECEPTOR; SCORPION VENOM; TOXIN TX4(6-1); UNCLASSIFIED DRUG;

SPIDER; TOXIN;

AMINO ACID SEQUENCE; ANIMAL TISSUE; ARTICLE; BINDING SITE; CENTRAL NERVOUS SYSTEM; CONTROLLED STUDY; ELECTROPHYSIOLOGY; EVOKED RESPONSE; NONHUMAN; PROTEIN BINDING; PROTEIN INTERACTION; RAT; SEQUENCE ANALYSIS; SODIUM CHANNEL; SODIUM CURRENT; SPIDER;

ARANEAE; HEXAPODA; INSECTA; MAMMALIA; MUS; PHONEUTRIA NIGRIVENTER; SCORPIONES;

EID: 0036138970     PISSN: 00221910     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0022-1910(01)00143-3     Document Type: Article

References (45)

1. Two classes of channel-specific toxins from funnel web spider venom
2. Structure and properties of omega-agatoxin IVB, a new antagonist of P-type calcium channels
3. Effects of a toxic fraction PhTx2, from the spider Phoneutria nigriventer on the sodium current
4. Isolation and characterization of glutamate receptor antagonists from venoms of orb-web spiders
5. Molecular mechanisms of neurotoxin action on voltage-gated sodium channels
6. Scorpion alpha-like toxins, toxic to both mammals and insects, differentially interact with receptor site 3 on voltage-gated sodium channels in mammals and insects
7. Properties of the venom from the South American 'armed' spider Phoneutria nigriventer (Keyserling, 1891)
8. Isolation, synthesis and pharmacological characterization of δ-palutoxins IT, novel insecticidal toxins from the spider Paracoelotes luctuosus (Amaurobiidae)
9. 2+
10. On the binding of two scorpion toxins to the central nervous system of the cockroach Periplaneta americana
11. Structure and pharmacology of spider venom neurotoxins
12. Purification and amino acid sequence of the insecticidal neurotoxin Tx4(6-1) from the venom of the 'armed' spider Phoneutria nigriventer (Keyserling, 1891)
13. Purification and pharmacological activity of two potent insecticidal neurotoxins from Phoneutria nigriventer spider venom
14. The structure of a novel insecticidal neurotoxin, omega-atracotoxin-HV1, from the venom of an Australian funnel web spider
15. Sodium channels as targets for neurotoxins: Mode of action and interaction of neurotoxins with receptor sites on sodium channels
16. Scorpion toxins affecting sodium current inactivation bind to distinct homologous receptor sites on rat brain and insect sodium channels
17. Fonctionnel anatomy of scorpion toxins affecting sodium channels
18. + channels
19. An improved vaseline gap voltage-clamp for skeletal muscle fibers
20. Strategy and tactics in receptor binding studies
21. Spider venom contains specific receptor blocker of glutaminergic synapses
22. + channels
23. 2+-independent insulin exocytosis induced by alpha-latrotoxin requires latrophilin, a G protein-coupled receptor
24. Delta-atracotoxins from Australian funnel-web spiders compete with scorpion alpha-toxin binding on both rat and insect sodium channels
25. Alpha-latrotoxin alters spontaneous and depolarization-evoked quantal release from rat adrenal chromaffin cells: Evidence for multiple modes of action
26. Blocking and isolation of a calcium channel from neurons in mammals and cephalopods utilizing a toxin fraction (FTX) from funnel-web spider poison
27. Protein measurement with the Folin phenol reagent
28. PhTx4, a new class of toxins from Phoneutria nigriventer spider venom, inhibits the glutamate uptake in rat brain synaptosomes
29. Selective peptide antagonist of the class E calcium channel from the venom of the tarantula Hysterocrates gigas
30. Modification of sodium channel gating and kinetics by versutoxin from Australian funnel-web spider Hadronyche versuta
31. Selective alteration of sodium channel gating by Australian funnel-web spider toxins
32. Characterization of the effects of robustoxin, the lethal neurotoxin from the Sydney funnel-web spider Atrax robustus, on sodium channel activation and inactivation
33. Three-dimensional structure analysis of μ-agatoxins: Further evidence for common motifs among neurotoxins with diverse ion channel specificities
34. Solution structure of robustoxin, the lethal neurotoxin from the funnelweb spider Atrax robustus
35. Improved tools for biological sequence comparison
36. Pharmacological properties of insect axons: A review
37. Les toxines antiinsectes de scorpions: Historique, modes d'actions et perspectives
38. Current-voltage relations in the isolated giant axon of the cockroach under voltage-clamp conditions
39. Arthropod venoms as tools for the study of neuromuscular transmission
40. Effect of deltamethrin treatment on lepidopteran larvae infected with baculoviruses expressing insect-selective toxins μ-Aga-IV, AS II, or Sh 1
41. Radioiodination of scorpion and snake toxins
42. + channel alpha subunit
43. Purification and characterization of two classes of neurotoxins from the funnel web spider Agelenopsis aperta
44. Slowly-reversible block of glutamate receptor-channels by venoms of the spiders, Argiope trifasciata and Araneus gemma
45. Characterization of six toxins from the venom of the Moroccan scorpion Buthus occitanus mardochei