Increased risk for therapy-associated hematologic malignancies in patients with carcinoma of the breast and combined homozygous gene deletions of glutathione transferases M1 and T1

Leukemia Research

Volumn 26, Issue 3, 2002, Pages 249-254

  Haase, Detlef ^a   Binder, Claudia ^a   Bünger, Jürgen ^a   Fonatsch, Christa ^b   Streubel, Berthold ^b   Schnittger, Susanne ^c   Griesinger, Frank ^a   Westphal, Götz ^a   Schoch, Claudia ^c   Knopp, Agnes ^d   Berkovicz, Dinko ^a   Krieger, Otto ^e   Wörmann, Bernhard ^f   Hilgers, Reinhard ^a   Hallier, Ernst ^a   Schulz, Thomas ^a  

^a UNIVERSITY OF GÖTTINGEN   (Germany)

^b UNIVERSITY OF VIENNA   (Austria)

^c UNIVERSITY OF MUNICH   (Germany)

^d UNIVERSITY OF ROSTOCK   (Germany)

^e ELISABETHINEN HOSPITAL   (Austria)

^f Department of Internal Medicine   (Germany)

Author keywords

AML; Breast cancer; Detoxification; GST; MDS; Secondary leukemia; Therapy associated leukemia

Indexed keywords

ANTINEOPLASTIC AGENT; CYCLOPHOSPHAMIDE; FLUOROURACIL; GLUTATHIONE TRANSFERASE; GOLD DERIVATIVE; ISOENZYME; METHOTREXATE; RADIOACTIVE IODINE;

ACUTE GRANULOCYTIC LEUKEMIA; ADOLESCENT; ADULT; AGED; ARTICLE; BONE MARROW BIOPSY; BREAST CARCINOMA; CHEMOTHERAPY; CHROMOSOME BREAKAGE; CONTROLLED STUDY; CYTOGENETICS; DNA DETERMINATION; FEMALE; GENE DELETION; GENOTYPE; HEMATOLOGIC DISEASE; HODGKIN DISEASE; HUMAN; KARYOTYPE; LUNG CANCER; MAJOR CLINICAL STUDY; MALE; METASTASIS; MULTIPLE MYELOMA; MYELODYSPLASTIC SYNDROME; NONHODGKIN LYMPHOMA; OVARY CANCER; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; RADIOTHERAPY; RETROSPECTIVE STUDY; RHEUMATOID ARTHRITIS; RISK ASSESSMENT; SCHOOL CHILD; TESTIS CANCER; THYROID CANCER;

ADULT; AGED; AGED, 80 AND OVER; ANTINEOPLASTIC AGENTS; BONE MARROW CELLS; BREAST NEOPLASMS; BREAST NEOPLASMS, MALE; CHROMOSOME ABERRATIONS; FEMALE; GENE DELETION; GENOTYPE; GLUTATHIONE TRANSFERASE; HEMATOLOGIC NEOPLASMS; HOMOZYGOTE; HUMANS; KARYOTYPING; LEUKEMIA, MYELOCYTIC, ACUTE; LEUKEMIA, RADIATION-INDUCED; LYMPHOCYTES; MALE; MIDDLE AGED; MYELODYSPLASTIC SYNDROMES; RADIOTHERAPY; RETROSPECTIVE STUDIES; RISK FACTORS; TRANSLOCATION, GENETIC;

EID: 0036138886     PISSN: 01452126     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0145-2126(01)00124-2     Document Type: Article

References (28)

1. Leukemias and myelodysplastic syndromes secondary to drug, radiation, and environmental exposure
2. The molecular pathogenesis of treatment-induced (secondary) leukemias: foundations for treatment and prevention
3. Microsatellite instability and p53 mutations in therapy-related leukemia suggests mutator phenotype
4. Association of CYP3A4 genotype with treatment-related leukemia
5. The glutathione S-transferase supergene family: regulation of GST and the contribution of the isoenzymes to cancer chemoprotection and drug resistance
6. Human lung carcinogen-DNA adduct levels mediated by genetic polymorphisms in vivo
7. Isoenzyme(s) of glutathione transferase (class μ) as a marker for the susceptibility to lung cancer: a follow up study
8. Relationship between the GSTM1 genetic polymorphism and susceptibility to bladder, breast and colon cancer
9. Association between glutathione S-transferase M1, P1, and T1 genetic polymorphisms and development of breast cancer
10. Increased risk for myelodysplastic syndromes in individuals with glutathione transferase theta 1 (GSTT1) gene defect
11. Glutathione S-transferase gene deletions in myelodysplasia
12. Glutathione S-transferase theta 1 (GSTT1) gene defect in myelodysplasia and acute myeloid leukaemia
13. Proposals for the classification of the myelodysplastic syndromes
14. Proposed revised criteria of the classification of acute myeloid leukemia
15. Evidence for malignant transformation in acute myeloid leukemia at the level of early hematopoietic stem cells by cytogenetic analysis of CD34+ subpopulations
16. A simple salting out procedure for extracting DNA from human nucleated cells
17. Genetic risk and carcinogen exposure: a common inherited defect of the carcinogen-metabolism gene glutathione S-transferase M1 (GSTM 1) that increases susceptibility to bladder cancer
18. Human glutathione S-transferase Theta (GSTT1): cDNA cloning and the characterization of a genetic polymorphism
19. Comparative genotyping and phenotyping of glutathione S-transferase GSTT1
20. Akute myeloische Leukämie
21. Reduced topoisomerase II and elevated alpha class glutathione S-transferase expression in a multidrug resistant CHO cell line highly cross-resistant to mitomycin C
22. Role of cellular glutathione and glutathione S-transferase in the expression of alkylating agent toxicity in human breast cancer cells
23. GST-pi-gene-transduced hematopoietic progenitor cell transplantation overcomes the bone marrow toxicity of cyclophosphamide in mice
24. Glutathione-S-transferase as a selective inhibitor of oncogenic ras-p21-induced mitogenic signaling through blockade of activation of jun by jun-N-terminal kinase
25. Transfection of glutathione S-transferase (GST)-pi antisense complementary DNA increases the sensitivity of a colon cancer cell line to adriamycin, cisplatin, melphalan, and etoposide