Alteration of amino acids in VP2 of very virulent infectious bursal disease virus results in tissue culture adaptation and attenuation in chickens

Journal of General Virology

Volumn 83, Issue 1, 2002, Pages 121-129

  Van Loon, A A W M ^a   De Haas, N ^a   Mundt, E ^a  

^a FEDERAL RESEARCH INSTITUTE FOR ANIMAL HEALTH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID; VIRUS PROTEIN;

ADAPTATION; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CHICKEN; CONTROLLED STUDY; EMBRYO; GENETIC CODE; INFECTIOUS BURSAL DISEASE VIRUS; MOLECULAR CLONING; MORBIDITY; MORTALITY; NONHUMAN; PATHOGENICITY; PRIORITY JOURNAL; PROVOCATION TEST; SITE DIRECTED MUTAGENESIS; TISSUE CULTURE; VIRUS ATTENUATION; VIRUS CULTURE; VIRUS INFECTION; VIRUS REPLICATION; VIRUS STRAIN; VIRUS VIRULENCE;

ANIMALIA; GALLUS GALLUS; INFECTIOUS BURSAL DISEASE VIRUS; RNA VIRUSES;

EID: 0036136631     PISSN: 00221317     EISSN: None     Source Type: Journal    
DOI: 10.1099/0022-1317-83-1-121     Document Type: Article

References (34)

1. A comparison of the sequences of segment A of four infectious bursal disease virus strains and identification of a variable region in VP2
2. A non-canonical Lon proteinase deficient of the ATPase domain employs the Ser-Lys catalytic dyad to impose broad control over the life cycle of a double-stranded RNA virus
3. Efficient rescue of infectious bursal disease virus from cloned cDNA: Evidence for involvement of the 3′-terminal sequence in genome replication
4. Rescue of very virulent and mosaic infectious bursal disease virus from cloned cDNA: VP2 is not the sole determinant of the very virulent phenotype
5. High maternal antibodies help chicks beat virulent strains
6. Coding sequences of both genome segments of a European 'very virulent' infectious bursal disease virus
7. Mortality associated with Gumboro disease
8. Outbreak of virulent infectious bursal disease in East Anglia
9. An apparently new disease of chickens-avian nephrosis
10. Loss of virulence in a small plaque mutant of the infectious bursal disease virus
11. European-like pathogenic infectious bursal disease viruses in Brazil
12. Pathogenicity and preliminary antigenic characterization of six infectious bursal disease virus strains isolated in France from acute outbreaks
13. Antigenic and genetic relationship between European very virulent infectious bursal disease viruses and an early West African isolate
14. Antigenicity, pathogenicity, and immunogenicity of small and large plaque infectious bursal disease virus clones
15. Rapid and efficient site-specific mutagenesis without phenotypic selection
16. Pathogenic and structural properties of wild type infectious bursal disease virus (IBDV) and virus grown in vitro
17. Family Birnaviridae
18. Adaption of very virulent infectious bursal disease virus to chicken embryonic fibroblasts by site-directed mutagenesis of residues 279 and 284 of viral coat protein VP2
19. Isolation and serological studies with infectious bursal disease virus from fowl, turkeys and ducks: Demonstration of a second serotype
20. Formation, characterization and interfering capacity of a small plaque mutant and of incomplete virus particles of infectious bursal disease virus
21. Tissue culture infectivity of different strains of infectious bursal disease virus is determined by distinct amino acids in VP2
22. Complete nucleotide sequences of 5′-and 3′-noncoding regions of both genome segments of different strains of infectious bursal disease virus
23. Synthetic transcripts of double-stranded birnavirus genome are infectious
24. Identification of a novel viral protein in infectious bursal disease virus-infected cells
25. Immunsuppressive effect of a highly virulent infectious bursal disease virus isolated in Japan
26. The structural polypeptide VP3 of infectious bursal disease virus carries group- and serotype-specific epitopes
27. Chimeras in noncoding regions between serotypes I and II of segment A of infectious bursal disease virus are viable and show pathogenic phenotype in chickens
28. Naturally occurring-neutralizing monoclonal antibody escape variants define the epidemiology of infectious bursal disease virus in the United States
29. Properties of RNA polymerase activity associated with infectious bursal disease virus and characterization of its reaction products
30. Nucleotide sequence of infectious bursal disease virus segment A delineates two major open reading frames
31. Acute infectious bursal disease in poultry: Isolation and characterization of a highly virulent strain
32. Rapid quantification of infectious bursal disease (IBD) challenge, field or vaccine virus strains
33. In vitro attenuation of highly virulent infectious bursal disease virus: Some characteristics of attenuated strains
34. Identification of sequence changes responsible for the attenuation of highly virulent infectious bursal disease virus