Detection of vitamin K-dependent proteins in venoms with a monoclonal antibody specific for γ-carboxyglutamic acid

Toxicon

Volumn 40, Issue 4, 2002, Pages 447-453

  Brown, M A ^a   Hambe, B ^a   Furie, B ^b   Furie, B C ^b   Stenflo, J ^a   Stenberg, L M ^a  

^a LUND UNIVERSITY   (Sweden)

^b HARVARD MEDICAL SCHOOL   (United States)

Author keywords

Cone snail; Conotoxins; Gamma carboxyglutamic acid; Gla; Snake venom; Vitamin K

Indexed keywords

4 CARBOXYGLUTAMIC ACID; AMINO ACID; BLOOD CLOTTING FACTOR 10A; CALCIUM ION; CARBOXYL GROUP; CHELATING AGENT; GLUTAMIC ACID; MONOCLONAL ANTIBODY; NEUROTOXIN; POLYPEPTIDE; PROTEIN; SNAIL VENOM; SNAKE VENOM; VITAMIN K GROUP;

AMINO ACID ANALYSIS; ANTIBODY SPECIFICITY; ARTICLE; BIOSYNTHESIS; CONTROLLED STUDY; IMMUNOFLUORESCENCE TEST; MOLECULAR RECOGNITION; NONHUMAN; PEPTIDE SYNTHESIS; PRIORITY JOURNAL; SALIVATION; SNAIL; SNAKE; WESTERN BLOTTING;

1-CARBOXYGLUTAMIC ACID; AMPHIBIAN VENOMS; ANIMALS; ANTIBODIES, MONOCLONAL; ANURA; BIOLOGICAL ASSAY; BLOOD PROTEINS; BLOTTING, WESTERN; ELAPID VENOMS; FACTOR XA; FLUORESCENT ANTIBODY TECHNIQUE; MOLLUSK VENOMS; PEPTIDES; SALIVARY GLANDS; SNAILS; SNAKES; VITAMIN K;

ACANTHOPHIINAE; GASTROPODA; SERPENTES;

EID: 0036135796     PISSN: 00410101     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0041-0101(01)00233-1     Document Type: Article

References (40)

1. A conserved motif within the vitamin K-dependent carboxylase gene is widely distributed across animal phyla
2. Identification and purification of vitamin K-dependent proteins and peptides with monoclonal antibodies specific for γ-carboxyglutamyl (Gla) residues
3. In vitro coagulant properties of venoms from Australian snakes
4. Post-translationally modified neuropeptides from Conus venoms
5. The mechanism of action of vitamin K
6. Mollusc-specific toxins from the venom of Conus textile neovicarius
7. Vitamin K and the biosynthesis of prothrombin - V: γ-carboxyglutamic acids, the vitamin K-dependent structures in prothrombin
8. Structure-function properties of venom components from Australian elapids
9. The molecular basis of blood coagulation
10. Higher-level snake phylogeny inferred from mitochondrial DNA sequences of 12S rRNA and 16S rRNA genes
11. Action of snake venom components on the haemostatic system
12. Amino acid sequence of Trocarin, a prothrombin activator from Tropidechis carinatus venom: Its structural similarity to coagulation factor Xa
13. Structure determination of two conotoxins from Conus textile by a combination of matrix-assisted laser desorption/ionization time-of-flight and electrospray ionization mass spectrometry and biochemical methods
14. Phylogenetic relationships of terrestrial Australo-Papuan elapid snakes (subfamily Hydrophiinae) based on cytochrome b and 16S rRNA sequences
15. Cleavage of structural proteins during the assembly of the head of bacteriophage T4
16. Identification of a Drosophila vitamin K-dependent γ-glutamyl carboxylase
17. The spasmodic peptide defines a new conotoxin superfamily
18. Purification and characterization of a prothrombin activator from the venom of the Australian brown snake, Pseudonaja textilis textilis
19. Sequence from picomole quantities of proteins electroblotted onto polyvinylidene difluoride membranes
20. γ-Carboxyglutamate in a neuroactive toxin
21. Vitamin K-dependent proteins
22. Diversity of Conus neuropeptides
23. Structural and functional similarity between pseutarin - A snake venom group III prothrombin activator from Pseudonaja textilis, and mammalian prothrombinase complex
24. 2+ influx
25. Structural and functional properties of snake venom prothrombin activators
26. Phylogenetic relationships of elapid snakes based on cytochrome b mtDNA sequences
27. Prothrombin activation by an activator from the venom of Oxyuranus scutellatus (Taipan snake)
28. Identification of a vitamin K-dependent carboxylase in the venom duct of a Conus snail
29. A functional prothrombin gene product is synthesized by human kidney cells
30. Synthesis of γ-carboxylated polypeptides by α-cells of the pancreatic islets
31. Contributions of Gla and EGF-like domains to the function of vitamin K-dependent coagulation factors
32. Vitamin K-dependent proteins in blood coagulation
33. Vitamin K dependent modifications of glutamic acid residues in prothrombin
34. Vitamin K-dependent carboxylase
35. A comparative study of the biological properties of Australian elapid venoms
36. Purification and properties of a prothrombin activator from the venom of Notechis scutatus scutatus
37. The cardiovascular, coagulation and haematological effects of tiger snake (Notechis scutatus) prothrombin activator and investigation of release of vasoactive substances
38. On a potential global role for vitamin K-dependent γ-carboxylation in animal systems: Evidence for a γ-glutamyl carboxylase in Drosophila
39. Characterization of the prothrombin activator from the venom of Oxyuranus scutellatus scutellatus (Taipan venom)
40. Cloning and expression of the cDNA for human γ-glutamyl carboxylase