A metabolic hypothesis of cell growth and death in pancreatic cancer

Pancreas

Volumn 24, Issue 1, 2002, Pages 26-33

  Boros, L G ^a   Lee, W N P ^a   Go, V L W ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Cancer; Glucose intermediary metabolism; Growth signaling pathways; Pentose cycle ribose synthesis

Indexed keywords

GENISTEIN; GLEEVAC; IMATINIB; TRANSFORMING GROWTH FACTOR BETA;

ARTICLE; CELL DEATH; CELL GROWTH; CELL METABOLISM; CELL TRANSFORMATION; GLUCOSE UTILIZATION; HUMAN; NUCLEIC ACID SYNTHESIS; PANCREAS CANCER; PHOSPHORYLATION; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION; TUMOR GROWTH;

APOPTOSIS; CARBON RADIOISOTOPES; CELL CYCLE; CELL DIFFERENTIATION; CELL DIVISION; CITRIC ACID CYCLE; DEUTERIUM; ENZYME INHIBITORS; GENISTEIN; GLUCOSE; GLYCOLYSIS; HUMANS; ISOTOPES; MASS SPECTROMETRY; PANCREATIC NEOPLASMS; PHENOTYPE; SIGNAL TRANSDUCTION; TRANSFORMING GROWTH FACTOR BETA; TUMOR CELLS, CULTURED;

EID: 0036135276     PISSN: 08853177     EISSN: None     Source Type: Journal    
DOI: 10.1097/00006676-200201000-00004     Document Type: Article

References (46)

1. Association of poor prognosis with loss of 12q, 17p, and 18q, and concordant loss of 6q/17p and 12q/18q in human pancreatic ductal adenocarcinoma
2. K-ras gene mutations and loss of heterozygosity at the p53 gene locus relative to histological characteristics of mucin-producing tumors of the pancreas
3. The Breast Cancer Information Core: Database design, structure, and scope
4. Genetic alterations in human prostate cancer: A review of current literature
5. Genetic heterogeneity in acute myeloid leukemia: Maximizing information flow from MuLV mutagenesis studies
6. Genetic and Hormonal Risk Factors in Breast Cancer
7. Molecular mechanisms and pathways in bladder cancer development and progression
8. The epigenetics of colorectal cancer
9. On the origin of cancer cells
10. The unitarian or trophoblastic thesis of cancer
11. Pathways of carbohydrate metabolism and their physiological significance
12. Fluorine-18-fluorodeoxy-glucose-guided breast cancer surgery with a positron-sensitive probe: Validation in preclinical studies
13. In vivo assessment of glucose metabolism in hepatocellular carcinoma with FDG-PET
14. The application of PET in clinical oncology
15. F-18 fluorodeoxyglucose PET in vivo evaluation of pancreatic glucose metabolism for detection of pancreatic cancer
16. 13C-glucose in rats
17. Analysis of tricarboxylic acid cycle using mass isotopomer ratios
18. Isotopomer study of lipogenesis in human hepatoma cells in culture: Contribution of carbon and reducing hydrogen from glucose
19. Gensitein inhibits nonoxidative ribose synthesis in MIA pancreatic adenocarcinoma cells: A new mechanism of controlling tumor growth
20. A comparison of C14-labeling patterns in deoxyribose and ribose in mammalian cells
21. 14C and estimation of the rates of transaldolase, transketolase, the contribution of the pentose cycle, and ribose phosphate synthesis
22. Mass isotopomer pattern and precursor-product relationship
23. 13C]Glucose
24. Isotopomer study of lipogenesis in human hepatoma cells in culture: Contribution of carbon and hydrogen atoms from glucose
25. Cyclosporine induces cancer progression by a cell-autonomous mechanism
26. Transforming growth factor beta2 promotes glucose carbon incorporation into nucleic acid ribose through the nonoxidative pentose cycle in lung epithelial carcinoma cells
27. The anti-proliferative effects of tyrosine kinase inhibitors towards tamoxifen-sensitive and tamoxifen-resistant human breast cancer cell lines in relation to the expression of epidermal growth factor receptors (EGF-R) and the inhibition of EGF-R tyrosine kinase
28. Oxidative stress induces protein kinase D activation in intact cell: Involvement of Src and dependence on protein kinase C
29. Genistein-induced G2-M arrest, p21WAF1 upregulation, and apoptosis in a non-small-cell lung cancer cell line
30. Soybean phytochemicals inhibit the growth of transplantable human prostate carcinoma and tumor angiogenesis in mice
31. Glucose deprivation-induced oxidative stress in human tumor cells. A fundamental defect in metabolism?
32. A unique glucose-dependent apoptotic pathway induced by c-Myc
33. Deregulation of glucose transporter I and glycolytic gene expression by c-Myc
34. Proliferative activity and tumorigenic conversion: Impact on cellular metabolism in 3-dimensional culture
35. Tumor growth modulation by sense and antisense vascular endothelial growth factor gene expression: Effects on angiogenesis, vascular permeability, blood volume, blood flow, fluorodeoxyglucose uptake, and proliferation of human melanoma intracerebral xenografts
36. Modulation of type M2 pyruvate kinase activity by the human papillomavirus type 16 E7 oncoprotein
37. Deregulation of glucose transporter I and glycolytic gene expression by c-Myc
38. An inducible gene product for 6-phosphofructo-2-kinase with an AU-rich instability element: Role in tumor cell glycolysis and the Warburg effect
39. Overexpression of transketolase: A mechanism by which thiamine supplementation promotes cancer growth
40. Oxythiamine and dehydroeplandrosterone inhibit the nonoxidative synthesis of ribose and tumor cell proliferation
41. Oxythiamine and dehydroepiandrosterone induce a G1 phase cycle arrest in Ehrlich's tumor cells through inhibition of the pentose cycle
42. Metabolic effects of fermented wheat germ extract with anti-tumor properties in cultured MIA pancreatic adenocarcinoma cells
43. Wheat germ extract decreases glucose uptake and RNA ribose formation but increases fatty acid synthesis in MIA pancreatic adenocarcinoma cells
44. First clinical data of a natural immunomodulator in colorectal cancer
45. Gleevec (ST1571) influences metabolic enzyme activities and glucose carbon flow toward nucleic acid and fatty acid synthesis in myeloid tumor cells