A pilot study evaluating the safety and microbiologic efficacy of an economically viable antimicrobial lozenge in patients with head and neck cancer receiving radiation therapy

Head and Neck

Volumn 24, Issue 1, 2002, Pages 6-15

  El Sayed, Samy ^a   Epstein, Joel ^b   Minish, Erin ^c   Burns, Patricia ^c   Hay, John ^b   Laukkanen, Ethan ^d  

^a OTTAWA REGIONAL CANCER CENTRE   (Canada)

^b BRITISH COLUMBIA CANCER AGENCY   (Canada)

^c CANCERCARE MANITOBA   (Canada)

^d Centre Regional De Cancerologie De Windsor   (Canada)

Author keywords

Antimicrobial lozenge; Oral microbial flora; Oral mucositis; Radiation therapy

Indexed keywords

ANTIINFECTIVE AGENT; BACITRACIN; CLOTRIMAZOLE; GENTAMICIN;

ADULT; AGED; ANTIMICROBIAL THERAPY; ARTICLE; BACTERIAL FLORA; CANDIDA; CLINICAL ARTICLE; CLINICAL TRIAL; DRUG EFFICACY; DRUG SAFETY; FEMALE; HEAD AND NECK CANCER; HUMAN; LOZENGE; MALE; MUCOSA INFLAMMATION; MULTICENTER STUDY; PHASE 2 CLINICAL TRIAL; PRIORITY JOURNAL; TREATMENT OUTCOME;

ADMINISTRATION, ORAL; ADULT; AGED; BACITRACIN; CARCINOMA, SQUAMOUS CELL; CLOTRIMAZOLE; FEMALE; FOLLOW-UP STUDIES; GENTAMICINS; HEAD AND NECK NEOPLASMS; HUMANS; MALE; MICROBIAL SENSITIVITY TESTS; MIDDLE AGED; MOUTH MUCOSA; PILOT PROJECTS; RADIATION DOSAGE; RADIATION INJURIES; RADIOTHERAPY, ADJUVANT; STOMATITIS; TREATMENT OUTCOME;

EID: 0036134841     PISSN: 10433074     EISSN: None     Source Type: Journal    
DOI: 10.1002/hed.10044     Document Type: Article

References (92)

1. Radiation mucositis: A new approach to prevention and treatment
2. Radiation therapy and pain in patients with head and neck cancer
3. Oral care of cancer patients undergoing head and neck irradiation
4. Patient reports of complications of bone marrow transplantation
5. Acute oral pain and mucositis in bone marrow transplant and leukemia patients: Data from a pilot study
6. Extramedullary toxicity in bone marrow transplantation using busulfan and cyclophosphamide conditioning
7. High dose busulphan/cyclophosphamide for autologous bone marrow transplantation is associated with minimal non-hemopoietic toxicity
8. Intensive conditioning regimen for bone marrow transplantation in children with high-risk haematological malignancies
9. A longitudinal study of oral ulcerative mucositis in bone marrow transplant recipients
10. Patterns of mucositis and pain in patients receiving preparative chemotherapy and bone marrow transplantation
11. Oral mucositis in patients undergoing bone marrow transplantation
12. Regimenrelated toxicity in patients undergoing bone marrow transplantation
13. Role of accelerated fractionated irradiation for supraglottic carcinoma: Assessment of results
14. Preliminary results of a randomized trial comparing neoadjuvant chemotherapy (cisplatin, epirubicin, bleomycin) plus radiotherapy vs radiotherapy alone in stage IV(> or = N2, M0) undifferentiated nasopharyngeal carcinoma: A positive effect on progression-free survival. International Nasopharynx Cancer Study Group. VUMCA I trial
15. Prolonged continuous infusion of carboplatin and concomitant radiotherapy in advanced head and neck cancer. A phase I study
16. A pilot study of concomitant radiation and chemotherapy in patients with locally advanced head and neck cancer
17. Chemoradiotherapy for advanced inoperable head and neck cancer: A phase II study
18. Conventional vs accelerated fractionation in head and neck cancer
19. The hazard of accelerated tumor clonogenic repopulation during radiotherapy
20. Hyperfractionation for head and neck cancer
21. Twice-a-day versus once-a-day radiation therapy in head and neck cancer
22. Concomitant cisplatin chemotherapy and radiotherapy in advanced mucosal squamous cell carcinoma of the head and neck: Long-term results of the Radiation Therapy Oncology Group Study 81-17
23. Favorable long-term survival following induction chemotherapy with cisplatin, fluorouracil, and leucovorin and concomitant chemoradiotherapy for locally advanced head and neck cancer
24. Hyperfractionation in the reirradiation of head and neck cancers. Result of a pilot study
25. Five-year update of a randomized trial of alternating radiotherapy and chemotherapy compared with radiotherapy alone in treatment of unresectable squamous cell carcinoma of the head and neck
26. Radiation therapy alone or with concurrent low-dose daily either cisplatin or carboplatin in locally advanced unresectable squamous cell carcinoma of the head and neck: A prospective randomized trial
27. A phase III randomized trial comparing concurrent chemotherapy and radiotherapy with radiotherapy alone in resectable stage iii and iv squamous cell head and neck cancer: Preliminary results
28. Simultaneous radiochemotherapy versus radiotherapy alone in advanced head and neck cancer: A randomized multicenter study
29. Comparison of surgical complications after organ-preservation therapy in patients with stage iii or iv squamous cell head and neck cancer
30. Randomized trial of radiation therapy versus concomitant chemotherapy and radiation therapy for advanced-stage oropharynx carcinoma
31. Use of patient-controlled analgesia for pain control for children receiving bone marrow transplant
32. Quality-of-life management of patients with colorectal cancer
33. Evidence for a biopsychosocial model of cancer treatment-related pain
34. Management of orofacial pain in cancer patients
35. Chemoradiotherapy toxicity during bone marrow transplantation: Time course and variation in pain and nausea
36. Oral mucositis after bone marrow transplantation: A marker of treatment toxicity and predictor of hepatic veno-occlusive disease
37. Patterns of mucositis and pain in patients receiving preparative chemotherapy and bone marrow transplantation
38. Tandem autotransplantation for the treatment of metastatic breast cancer
39. The radiobiological basis for tissue reactions in the oral cavity following therapeutic X-irradiation
40. Iatrogenic salivary gland dysfunction
41. Oral findings in irradiated edentulous patients
42. Analysis of factors that correlate with mucositis in recipients of autologous and allogeneic stem-cell transplants
43. Risk factors associated with mucositis in cancer patients receiving 5-fluorouracil
44. Factors influencing oral cavity status during high-dose antineoplastic therapy: A secondary data analysis
45. Risk factors for oropharyngeal candidiasis in patients who receive radiation therapy for malignant conditions of the head and neck
46. Inhibition of adherence of Candida albicans by conventional and experimental antifungal drugs
47. Oral monilia study on patients with head and neck cancer during radiotherapy
48. The relationships among fluoride, cariogenic oral flora and salivary flow rate during radiation therapy
49. Yeast flora of the mouth and skin during and after irradiation for oral and laryngeal cancer
50. The effect of chlorhexidine and benzydamine mouthwashes on mucositis induced by therapeutic irradiation
51. The effect of chlorhexidine mouth rinses on human oral flora
52. Therapeutic use of chlorhexidine in bone marrow transplant patients: Case studies
53. Control of oral mucositis and candidiasis in marrow transplantation: A prospective, double-blind trial of chlorhexidine gluconate oral rinse
54. The effects of chlorhexidine on the oral microflora of bone marrow transplant patients
55. Oropharyngeal mucositis complicating bone marrow transplantation prognostic factors and the effect of chlorhexidine mouth rinse
56. Effects of chlorhexidine mouth rinse on oral health n patients with acute leukemia
57. Effect of chlorhexidine rinsing on the oropharyngeal ecology in patients with head and neck cancer who have irradiation mucositis
58. The effects of sublethal concentrations of chlorhexidine on bacterial pathogenicity
59. Chlorhexidine inactivation by saliva
60. Efficacy of chlorhexidine and nystatin rinses in prevention of oral complications in leukemia and bone marrow transplantation
61. Chlorhexidine prophylaxis for chemotherapy and radiotherapy-induced stomatitis: A randomized double-blind trial
62. Randomized trial of a chlorhexidine mouthwash for alleviation of radiation- induced mucositis
63. Selective decontamination
64. Scoring irradiation mucositis in head and neck cancer patients
65. Colonization index of the oral cavity: A novel technique for monitoring colonization defense
66. Antibiotic prophylaxis in cancer patients: Regimens of oral, non-absorbable antibiotics for prevention of infection during induction of remission
67. Effect of selective flora suppression on colonization, infection and mortality in critically ill patients: A one year, prospective consecutive study
68. Measurement of bound and free endotoxin by the limulus assay
69. Endotoxin and the inflammatory process
70. Inactivation of endotoxin by polymyxin B
71. Significant reduction of faecal endotoxin pool by oral polymyxin E and tobramycin in human volunteers
72. A re-evaluation of split-course technique for squamous cell carcinoma of the head and neck
73. Local control of oropharyngeal carcinoma after accelerated hyperfractionated radiotherapy schemes
74. Prevention of irradiation mucositis in head and neck cancer patients
75. Effect of selective elimination of the oral flora on mucositis in irradiated head and neck cancer patients
76. Randomized trial of a nonabsorbable antibiotic lozenge for alleviation of radiation-induced mucositis
77. The reduction of radiation mucositis by selective decontamination antibiotic pastilles: A placebo-controlled double-blind trial
78. Prevention of nosocomial infection in ventilated patients: Use of an antimicrobial pharyngeal nonabsorbable paste
79. Decreased acute toxicity by using midline mucosa-sparing blocks during radiation therapy for carcinoma of the oral cavity, oropharynx, and nasopharynx
80. Oral capsaicin provides temporary relief for oral mucositis pain secondary to chemotherapy/radiation therapy
81. Propantheline prevention of mucositis from etoposide
82. Herpes simplex virus and oral mucositis in children with cancer
83. Oral and pharyngeal herpes simplex virus infection after allogeneic bone marrow transplantation: Analysis of factors associated with infection
84. Clinical study of herpes simplex virus infection in leukemia
85. Prevention of oral mucositis in radiation therapy: A controlled study with benzydamine hydrochloride rinse
86. Prevention of oral mucositis in patients treated with high-dose chemotherapy and bone marrow transplantation: A randomised controlled trial comparing two protocols of dental care
87. The PROSELF Mouth Aware program: An effective approach for reducing chemotherapy-induced mucositis
88. Risk factors for chemotherapy-induced oral mucositis: Dental appliances, oral hygiene, previous oral lesions and history of smoking