Differential response of neural cells to trauma-induced free radical production in vitro

Neurochemical Research

Volumn 27, Issue 1-2, 2002, Pages 161-166

  Panickar, K S ^a   Jayakumar, A R ^a   Norenberg, M D ^a  

^a UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

Author keywords

Astrocytes; CNS trauma; Cyclosporin A; Free radicals; Microglia; Mitochondrial permeability transition; Neurons

Indexed keywords

CYCLOSPORIN A; FLUORESCENT DYE; FREE RADICAL;

ANIMAL CELL; ARTICLE; ASTROCYTE; BRAIN MITOCHONDRION; CELL CULTURE; CELL MEMBRANE PERMEABILITY; CONTROLLED STUDY; IN VITRO STUDY; INJURY; MICROGLIA; NERVE CELL; NEWBORN; NONHUMAN; PRIORITY JOURNAL; RAT; SCAVENGING SYSTEM;

ANIMALS; ASTROCYTES; BRAIN INJURIES; CALCINEURIN; CELLS, CULTURED; CYCLOSPORINE; FREE RADICALS; INTRACELLULAR MEMBRANES; MICROGLIA; MITOCHONDRIA; NEURONS; PERMEABILITY; RATS; REFERENCE VALUES; TACROLIMUS; TIME FACTORS;

ANIMALIA;

EID: 0036131371     PISSN: 03643190     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1014875210852     Document Type: Article

References (38)

1. Oxygen radicals in brain injury
2. Central nervous system trauma and stroke. I. Biochemical consideration for oxygen radical formation and lipid peroxidation
3. The role of oxygen radicals in traumatic injury: Clinical implications
4. Brain hydroxyl radical generation in acute experimental head injury
5. Free radical pathways in CNS injury
6. Oxypurinol inhibits free radical release from the cerebral cortex of closed head injured rats
7. alpha-phenyl-tert-butyl-nitrone inhibits free radical release in brain concussion
8. Cyclosporin A attenuates acute mitochondrial dysfunction following traumatic brain injury
9. Fluid percussion barotrauma chamber: A new in vitro model for traumatic brain injury
10. Mitochondrial participation in ischemic and traumatic neural cell death
11. Changes in extracellular levels of energy-related metabolites and amino acids following concussive brain injury to rats
12. Mitochondrial metabolism following traumatic brain injury in rats
13. Modulation of the mitochondrial permeability transition pore. Effect of protons and divalent cations
14. The mitochondrial permeability transition
15. Mitochondrial control of cell death
16. The mitochondrial permeability transition in cell death: A common mechanism in necrosis, apoptosis and autophagy
17. Mitochondrial permeability transition in the central system: Induction by calcium cycling-dependent and-independent pathways
18. Continuous infusion of cyclosporin A post-injury significantly ameliorates cortical damage following traumatic brain injury
19. The mitochondrial permeability transition in CNS trauma in vitro
20. Effect of ammonium chloride on the astrocyte benzodiazepine receptor
21. Preparation of primary cultures of mouse (rat) cerebellar granule cells
22. Fluid-percussion model of mechanical brain injury in the cat
23. Bcl-2 inhibition of neural death: Decreased generation of reactive oxygen species
24. Mitochondrial electron transport complex I is a potential source of oxygen free radicals in the failing myocardium
25. Respiratory activity in brain macrophages: A flow cytometric study on cultured rat microglia
26. Cytokine and free radical production by porcine microglia
27. Identification of hypoxanthine transport and xanthine oxidase activity in brain capillaries
28. Reactive microglia in cerebral ischemia: An early mediator of tissue damage?
29. Macrophage and microglial responses to cytokines in vitro: Phagocytic activity, proteolytic enzyme release, and free radical production
30. Neurons induce the activation of microglial cells in vitro
31. Microglial cells in culture express a prominent glutathione system for the defense against reactive oxygen species
32. Mitochondrial dysfunction and calcium perturbation induced by traumatic brain injury
33. Mitochondrial dysfunction after experimental traumatic brain injury: Combined efficacy of SNX-111 and U-101033E
34. The giant channel of the inner mitochondrial membrane is inhibited by cyclosporin A
35. Calcineurin phosphatase activity in T lymphocytes is inhibited by FK 506 and cyclosporin A
36. Cyclosporin A, but not FK 506, protects mitochondria and neurons against hypoglycemic damage and implicates the mitochondrial permeability transition in cell death
37. Mitochondrial implication in accidental and programmed cell death: Apoptosis and necrosis
38. Electrophysiology of the inner mitochondrial membrane