The inhibition of tryptophan hydroxylase, not protein synthesis, reduces the brain trapping of α-methyl-L-tryptophan: An autoradiographic study

Neurochemistry International

Volumn 40, Issue 7, 2002, Pages 603-610

  Tohyama, Yoshihiro ^a   Takahashi, Sho ^a   Merid, Maraki Fikre ^a   Watanabe, Arata ^a   Diksic, Mirko ^a  

^a MCGILL UNIVERSITY   (Canada)

Author keywords

p Chlorophenylalanine; Serotonin synthesis; Tryptophan hydroxylase; Methyl L tryptophan

Indexed keywords

CARBON 14; CYCLOHEXIMIDE; FENCLONINE; N METHYLTRYPTOPHAN; SEROTONIN; SODIUM CHLORIDE; TRYPTOPHAN HYDROXYLASE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; AUTORADIOGRAPHY; BRAIN; CONTROLLED STUDY; DRUG EFFECT; ENZYME INHIBITION; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN SYNTHESIS; RAT;

ANIMALS; AUTORADIOGRAPHY; BRAIN; CYCLOHEXIMIDE; ENZYME INHIBITORS; FENCLONINE; MALE; PROTEIN BIOSYNTHESIS; PROTEIN SYNTHESIS INHIBITORS; RATS; RATS, SPRAGUE-DAWLEY; SEROTONIN; TRYPTOPHAN; TRYPTOPHAN HYDROXYLASE;

EID: 0036126568     PISSN: 01970186     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0197-0186(01)00132-2     Document Type: Article

References (51)

1. 11C]methyl-L-tryptophan method for measuring rates of serotonin synthesis in the human brain
2. Depletion of serotonin using p-chlorophenylalanine (PCPA) and reserpine protects against the neurotoxic effects of p-chloroamphetamine (PCA) in the brain
3. A study of proposed determinants of brain tryptophan concentration in rats after portocaval anastomosis or sham operation
4. Simultaneous measurement of tyrosine and tryptophan hydroxylase activities in the rat brain in vivo using an inhibitor of the aromatic aminoacid decarboxylase
5. Evidence for the existence of monoamine-containing neurons in the central nervous system. I. Demonstration of monoamines in the cell bodies of brain stem neurons
6. Effect of p-chlorophenylalanine on hydroxylation of tryptophan in pineal and brain of rats
7. Comparative studies on the effect of p-chlorophenylalanine on hydroxylation of tryptophan in pineal and brain of rat
8. The serotonin neurons in nucleus raphe dorsalis of the adult rat: A light and electron microscope radioautographic study
9. Does labeled α-methyl-L-tryptophan images only blood brain barrier transport of tryptophan?
10. Labeled α-methyl-L-tryptophan as tracer to study brain serotonergic system
11. Study of the brain serotonergic system with labeled α-methyl-L-tryptophan
12. A new method to measure brain serotonin synthesis in vivo. I. Theory and basic data for a biological model
13. The serotonin synthesis rate measured in living dog brain by PET
14. The regional rate of serotonin synthesis estimated by the α-methyl-L-tryptophan method in rat brain from one-time method
15. Is α-methyl-L-tryptophan a good tracer for brain serotonin synthesis measurements, and does the lumped constant vary in different structures of the rat brain?
16. 14C]methyl-L-tryptophan (α-MTrp) and its correlation with regional serotonin synthesis, tryptophan incorporation into proteins, and permeability surface area products of tryptophan and α-MTrp
17. Molecular basis of inhibition of monooxygenases by p-chlorophenylalanines
18. 14C]p-chlorophenylalanine: A revision
19. 14C]p-chlorophenylalanine as an inhibitor of tryptophan 5-hydroxylase
20. Effect of p-chloroamphetamine on cerebral tryptophan-5-hydroxylase in vivo: A reexamination
21. Biochemical and autoradiographic measurements of brain serotonin synthesis rate in the freely moving rat: A reexamination of the α-methyl-L-tryptophan method
22. Tryptophan toxicity-time and dose-response in rats
23. End product inhibition of serotonin synthesis in the rat striatum
24. Tryptophan hydroxylase inhibition: The mechanism by which p-chlorophenylalanine depletes rat brain serotonin
25. p-Chlorophenylalanine: A specific depletor of brain serotonin and experimental therapeutics
26. The pharmacology of p-chlorophenylalanine, a selective depletor of serotonin stores
27. In vivo measurement of 5-hydroxytryptamine turnover rate in the rat brain from the conversion of C14-tryptophan to C14-5-hydroxytryptamine
28. Tryptophan hydroxylation: Measurement in pineal gland, brainstem and carcinoid tumor
29. Physiologic and drug-induced regulation of serotonin synthesis
30. Feedback control of rat brain 5-hydroxytryptamine synthesis
31. Regulation of serotonin biosynthesis in brain: Role of the high affinity uptake of tryptophan into serotonergic neurons
32. Tryptophan 5-hydroxylase: Approximation of half-life and rate of axonal transport
33. Comparative effects of p-chlorophenylalanine, p-chloroamphetamine and p-chloro-N-methylamphetamine on rat brain norepinephrine, serotonin and 5-hydroxyindole-3-acetic acid
34. The acute effects of reserpine and NSD-1015 on the brain serotonin synthesis rate measured by an autoradiographic method
35. D, L-Fenfluramine increases the 5HT synthesis rate in the terminals while decreasing it in the cell bodies of the rat brain
36. Influence of fluoxetine on regional serotonin synthesis in the rat brain
37. 14C]methyl-L-tryptophan
38. A new method to measure brain serotonin synthesis in vivo. II. A practical autoradiographic method tested in normal and lithium-treated rats
39. Effect of cycloheximide administered to rats in early postnatal life: Prolonged inhibition of DNA synthesis in the developing brain
40. Assays and properties of tryptophan 5-hydroxylase
41. Variation of tryptophan-5-hydroxylase concentration in the rat raphe dorsalis nucleus after p-chlorophenylalanine administration. I. A model to study the turnover of the enzymatic protein
42. How does displacement of albumin-bound tryptophan cause sustained increases in the free tryptophan concentration in plasma and 5-hydroxytryptamine synthesis in brain?
43. 14C] labeled tracer
44. The raphe nuclei of the rat brainstem: A cytoarchitectonic and immunohistochemical study
45. Effect of psychotropic drugs on tryptophan concentration in the rat brain
46. Rapid steady-state analysis of blood-brain transfer of L-Trp in rat, with special reference to the plasma protein binding
47. Synthesis of serotonin in traumatized rat brain
48. Determination of the lumped constant for the α-methyl-L-tryptophan method of estimating the rate of serotonin synthesis
49. Sleep patterns of the monkey and brain serotonin concentration. Effect of p-chlorophenylalanine