Evaluation of dextromethorphan N-demethylation activity as a biomarker for cytochrome P450 3A activity in man

Pharmacology and Toxicology

Volumn 90, Issue 2, 2002, Pages 82-88

  Kawashima, Yoshiaki ^a   Hagiwara, Mieko ^b   Inoue, Yoshimasa ^c   Someya, Toshiyuki ^a  

^a NIIGATA UNIVERSITY GRADUATE SCHOOL OF MEDICAL AND DENTAL SCIENCES   (Japan)

^b NIIGATA UNIVERSITY MEDICAL AND DENTAL HOSPITAL   (Japan)

^c Welfide Corporation   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

3 METHOXYMORPHINAN; BIOLOGICAL MARKER; CYTOCHROME P450 3A; DEXTROMETHORPHAN; DEXTRORPHAN; DRUG METABOLITE; MIDAZOLAM; NORLEVORPHANOL; UNCLASSIFIED DRUG;

ADULT; ARTICLE; CONTROLLED STUDY; CORRELATION ANALYSIS; DEMETHYLATION; DRUG ACTIVITY; DRUG CLEARANCE; DRUG DETERMINATION; DRUG METABOLISM; DRUG SCREENING; ENZYME ACTIVITY; HUMAN; HUMAN EXPERIMENT; MALE; NORMAL HUMAN; PRIORITY JOURNAL; URINALYSIS;

ADULT; ARYL HYDROCARBON HYDROXYLASES; BIOLOGICAL MARKERS; CYTOCHROME P-450 CYP3A; DEXTROMETHORPHAN; HUMANS; MALE; METABOLIC CLEARANCE RATE; METHYLATION; MIDAZOLAM; MIDDLE AGED; OXIDOREDUCTASES, N-DEMETHYLATING; SENSITIVITY AND SPECIFICITY;

STAPHYLOCOCCUS PHAGE 3A;

EID: 0036126454     PISSN: 09019928     EISSN: None     Source Type: Journal    
DOI: 10.1034/j.1600-0773.2002.900205.x     Document Type: Article

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