Statistical gene mapping of traits in humans - Hypertension as a complex trait: Is it amenable to genetic analysis?

Seminars in Nephrology

Volumn 22, Issue 2, 2002, Pages 105-114

  Nothnagel, Michael ^a,b   Ott, Jürg ^a  

^a ROCKEFELLER UNIVERSITY   (United States)

^b INFOGEN GmbH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

DISEASE PREDISPOSITION; GENE MAPPING; GENETIC LINKAGE; GENETIC RECOMBINATION; GILLES DE LA TOURETTE SYNDROME; HERITABILITY; HUMAN; HYPERTENSION; MATHEMATICAL MODEL; PRIORITY JOURNAL; REVIEW; TECHNIQUE;

EID: 0036122289     PISSN: 02709295     EISSN: None     Source Type: Journal    
DOI: 10.1053/snep.2002.30209     Document Type: Review

References (80)

1. The early history of statistical estimation of linkage
2. Linkage and association
3. Linkage analysis in nuclear families. 2: Relationship between affected sib-pair tests and lod score analysis
4. Genome scanning for linkage: An overview
5. Linkage analysis in the presence of errors iv: Joint pseudomarker analysis of linkage and/or linkage disequilibrium on a mixture of pedigrees and singletons when the mode of inheritance cannot be accurately specified
6. Initial sequencing and analysis of the human genome
7. The sequence of the human genome
8. On the mathematical foundations of theoretical statistics
9. Sequential tests for the detection of linkage
10. All LODs are not created equal
11. Genetic dissection of complex traits: Guidelines for interpreting and reporting linkage results
12. Effects of misspecifying genetic parameters in lod score analysis
13. Major strengths and weaknesses of the lod score: Method
14. The investigation of linkage between a quantitative trait and a marker locus
15. A sib-pair approach to interval mapping of quantitative trait loci
16. The power of interval mapping of quantitative trait loci, using selected sib pairs
17. A unified Haseman-Elston method for testing linkage with quantitative traits
18. Linkage analysis in nuclear families. 1: Optimality criteria for affected sib-pair tests
19. The affected-pedigree-member method of linkage analysis
20. Absence of linkage of phonological coding dyslexia to chromosome 6p23-p21.3 in a larger family data set
21. Parametric and nonparametric linkage analysis: A unified multipoint approach
22. Variance component methods for detecting complex trait loci
23. A twin-pronged attack on complex traits
24. The use of twins in quantitative trait locus mapping
25. Linkage but lack of association for blood pressure and the alpha-adducin locus in normotensive twins
26. Quantitative trait loci for blood pressure exist near the IGF-1, the Liddle syndrome, the angiotensin II-receptor gene and the renin loci in man
27. Beta-2 adrenergic receptor gene variations, blood pressure, and heart size in normal twins
28. Genetic influences on baroreflex function in normal twins
29. A cholesterol-lowering gene maps to chromosome 13q
30. High-resolution genetic mapping of complex traits
31. Linkage disequilibrium measures for fine-scale mapping: A comparison
32. Linkage disequilibrium and the search for complex disease genes
33. Linkage disequilibrium in the human genome
34. Genetics of HLA disease associations. The use of the haplotype relative risk (HRR) and the "haplo-delta" (Dh) estimates in juvenile diabetes from three racial groups
35. A haplotype-based 'haplotype relative risk' approach to detecting allelic associations
36. Transmission test for linkage disequilibrium: The insulin gene region and insulin-dependent diabetes mellitus (IDDM)
37. Sibling-based tests of linkage and association for quantitative traits
38. A sibship test for linkage in the presence of association: The sib transmission/disequilibrium test
39. A transmission disequilibrium test for quantitative trait loci
40. The transmission/disequilibrium test and parental-genotype reconstruction: The reconstruction-combined transmission/disequilibrium test
41. The family based association test method: Strategies for studying general genotypephenotype associations
42. Combined linkage and association sib-pair analysis for quantitative traits
43. Power of linkage versus association analysis of quantitative traits, by use of variance-components models, for sibship data
44. Genetic dissection of complex traits
45. The flexible genome
46. A pathway model of lipid metabolism to predict the effect of genetic variability on lipid levels
47. Sometimes it's hot, sometimes it's not
48. A multivariate method for detecting genetic linkage, with application to a pedigree with an adverse lipoprotein phenotype
49. Haseman and Elston revisited
50. Extension of the Haseman-Elston method to multiple alleles and multiple loci: Theory and practice for candidate genes
51. Multipoint interval mapping of quantitative trait loci, using sib pairs
52. Unbiased application of the transmission/disequilibrium test to multilocus haplotypes
53. Multipoint quantitative-trait linkage analysis in general pedigrees
54. A general model for the analysis of pedigree data
55. Construction of multilocus genetic maps in humans
56. Markov chain Monte Carlo segregation and linkage analysis for oligogenic models
57. MCMC segregation and linkage analysis
58. Descent graphs in pedigree analysis: Applications to haplotyping, location scores, and marker sharing statistics
59. Searching for alcoholism susceptibility genes using Markov chain Monte Carlo methods
60. Multipoint oligogenic analysis of age-at-onset data with applications to Alzheimer disease pedigrees
61. Multi-locus nonparametric linkage analysis of complex trait loci with neural networks
62. Neural network analysis of complex traits
63. Mapping genotype to phenotype for linkage analysis
64. Neural networks and disease association studies
65. Applications of neural networks for gene finding
66. The complexity of linkage analysis with neural networks
67. Statistical multilocus methods for disequilibrium analysis in complex traits
68. Selecting SNPs in two-stage analysis of disease association data: A model-free approach
69. Scan statistics to scan markers for susceptibility genes
70. A complete genome screen in sib pairs affected by Gilles de la Tourette syndrome
71. Identification of genetic markers associated with Gilles de la Tourette syndrome in an Afrikaner population
72. Significant linkage for Tourette syndrome in a large French Canadian family
73. Further evidence for linkage of Gilles de la Tourette syndrome (GTS) susceptibility loci on chromosomes 2p11, 8q22 and 11q23-24 in South African Afrikaners