Robustness of MetaNet graph models: Predicting control of urea production in humans

BioSystems

Volumn 65, Issue 1, 2002, Pages 61-78

  Kohn, Michael C ^a   Tohmaz, Abdul S ^b   Giroux, Karen J ^b   Blumenthal, Gregory M ^a   Feezor, Michael D ^c   Millington, David S ^c  

^a NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

^b BioKinetics Inc ^*  (United States)

^c DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Graph models; Metabolic regulation; Robustness; Urea cycle

Indexed keywords

AMINO ACID DERIVATIVE; ENZYME; REAGENT; UREA;

UREA;

ANALYTICAL ERROR; ARTICLE; BINDING SITE; CHEMICAL REACTION; DEVICE; FEEDBACK SYSTEM; KINETICS; LIGAND BINDING; MEMBRANE TRANSPORT; METABOLISM; MITOCHONDRIAL MEMBRANE; MODEL; PREDICTION; UREA CYCLE;

EID: 0036122013     PISSN: 03032647     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0303-2647(02)00002-3     Document Type: Article

References (69)

1. N-acetylglutamate synthetase (NAGS) deficiency: Diagnosis, clinical observations and treatment
2. Robustness in simple biochemical networks
3. Allosteric regulation of beef liver arginase activity by L-ornithine
4. Regulation of urea and citrulline synthesis under physiological conditions
5. Amino group transfer
6. Regulation of urea synthesis in vivo: Facts and speculations
7. Arginine, an indispensable amino acid for patients with inborn errors of urea synthesis
8. Urea cycle enzymes
9. Amino acid acylation: A mechanism of nitrogen excretion in inborn errors of urea synthesis
10. Enzymatic mechanism of creatine synthesis
11. Acute glucagon treatment in rats fed various protein diets
12. Evolutionary and comparative aspects of urea biosynthesis
13. Kinetic properties of carbamoyl-phosphate synthetase (ammonia) and ornithine carbamoyltransferase in permeabilized mitochondria
14. 13N-labeled glutamate, alanine, and glutamine(amide) in rat liver
15. Guanadinoacetate methyltransferase activity in tissues and cultured cells
16. Microcompartmentation of aspartate in rat liver mitochondria
17. Kinetic studies on mammalian liver carbamyl phosphate synthetase
18. Design of metabolic control for large flux changes
19. Co-operative components, spatial localization and oscillatory cellular dynamics
20. Glutamate dehydrogenase from rat brain
21. The purification and characterization of human kidney L-arginine:glycine amidinotransferase
22. Metabolism of amino acids and ammonia
23. Identification of the ornithine/citrulline carrier from rat liver mitochondria
24. The large-scale organization of metabolic networks
25. Control circuits for determination and transdetermination
26. Pyrimidine nucleotide metabolism and its compartmentation
27. Computer simulation of metabolism in palmitate-perfused rat heart. III. Sensitivity analysis
28. Propagation of information in MetaNet graph models
29. Molecular interaction map of the mammalian cell cycle control and DNA repair systems
30. Information flow and complexity of large-scale metabolic systems
31. Identification of regulatory properties of metabolic networks by graph theoretical modeling
32. A graph-theoretical analysis of metabolic regulation
33. Amplification and adaptation in regulatory and sensory systems
34. Molecular aspects of isolated and reconstituted carrier proteins from animal mitochondria
35. Isolation and functional reconstitution of the aspartate/glutamate carrier from mitochondria
36. Metabolite transport in mammalian mitochondria
37. Kinetic properties of aspartate transport in rat heart mitochondrial inner membranes
38. Glutamine as a precursor of urea
39. Hybrid Perti net representation of gene regulatory network
40. Circuit simulation of genetic networks
41. Ureogenesis
42. Zur organ und subzellularverteilung der transamindinase
43. Metabolic pathway of guanidino compounds in chronic renal failure
44. Labile methyl group balance in the human: The role of sarcosine
45. Isolation of arginosuccinase from bovine brain: Catalytic, physical and chemical properties compared to liver and kidney enzymes
46. Crystallization and properties of human liver ornithine aminotransferase
47. 2+ control of respiration in isolated rat liver mitochondria
48. Urea synthesis and ammonia metabolism
49. Enzyme and reactant concentrations and the regulation of urea synthesis
50. Enzymes of arginine and urea synthesis
51. Regulation of urea synthesis: Changes in the concentration of ornithine in the liver corresponding to changes in urea synthesis
52. Enzymatic analysis of citrullinemia (12 cases) in Japan
53. A mechanism for exact sensory adaptation based on receptor modification
54. Topological analysis of metabolic control
55. Subcellular distribution of adenine nucleotides and of metabolites of tricarboxylic acid cycle and gluconeogenesis in hepatocytes
56. Arginase
57. Distribution of metabolites between mitochondria and cytosol of perfused liver
58. Species-dependent compartmentation of guanine nucleotide metabolism in the vertebrate liver cell
59. Purification and properties of rat liver ornithine δ-transaminase
60. The metabolism of α-ketoglutarate
61. Acetylglutamate synthetase
62. Dynamical behaviour of biological regulatory networks, I. Biological role of feedback loops and practical use of the concept of the loop-characteristic state
63. Studies on the mechanism of action of kidney trasamidinase
64. Creatine: Biosynthesis, regulation, and function
65. Role and regulation of glutamate dehdyrogenases in ureogenesis
66. Metabolite distribution in isolated rat-liver cells and equilibium relationships of mitochondrial and cytosolic dehydrogenases