NXY-059. Treatment of ischemic stroke free, radical scavenger

Drugs of the Future

Volumn 27, Issue 3, 2002, Pages 240-247

  Sorbera, L A ^a   Leeson, P A ^a   Castaner J ^a   Del Fresno, M ^a  

^a PROUS SCIENCE   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

4 (4 FLUOROPHENYL) 2 METHYL 6 (5 PIPERIDINOPENTYLOXY)PYRIMIDINE; AEOL 10113; AEOL 10150; DEHYDROASCORBIC ACID; DISUFENTON SODIUM; EBSELEN; EDAROVONE; EUK 189; GT 015; GT 715; KR 31378; N [4 [4 [(3,4 DIHYDRO 6 HYDROXY 2,5,7,8 TETRAMETHYL 2H 1 BENZOPYRAN 2 YL)CARBONYL] 1 PIPERAZINYL]PHENYL] 2 THIOPHENECARBOXIMIDAMIDE; NICARAVEN; SCAVENGER; SPBN; SUN N8075; TRILAZAD MESYLATE; UNCLASSIFIED DRUG;

BLOOD BRAIN BARRIER; CEREBROVASCULAR ACCIDENT; DOSE RESPONSE; DRUG EFFICACY; DRUG SAFETY; DRUG STRUCTURE; DRUG SYNTHESIS; DRUG TOLERABILITY; NEUROPROTECTION; REVIEW; SUBARACHNOID HEMORRHAGE; TREATMENT CONTRAINDICATION; TREATMENT OUTCOME;

EID: 0036115894     PISSN: 03778282     EISSN: None     Source Type: Journal    
DOI: 10.1358/dof.2002.027.03.660638     Document Type: Review

References (22)

1. Treatment of acute ischemic stroke
2. Comparison of the radical trapping ability of PBN, S-PPBN and NXY-059
3. Neuroprotective effects of a novel nitrone, NXY-059, after transient focal cerebral ischemia in the rat
4. Effect of NXY-059 on infarct volume after transient or permanent middle cerebral artery occlusion in the rat: Studies on dose, plasma concentration and therapeutic time window
5. NXY-059 prevents downregulation of Akt and release of cytochrome C after focal cerebral ischemia
6. NXY-059, a novel free radical trapping compound, reduces cortical infarction after permanent focal cerebral ischemia in the rat
7. Efficacy of disodium 4-[(tert-butyl-imino)-methyl]benzene-1,3-disulfonate N-oxide (NXY-059), a free radical trapping agent, in a rat model of hemorrhagic stroke
8. NXY-059 pharmacology part 1: The spin trap agent disodium-[(tert-butylimino)methyl]benzene-1,3-disulfonate N-oxide (NXY-059) is neuroprotective in a rabbit small clot embolic stroke model. Combination studies with tissue plasminogen activator (tPA)
9. NXY-059 pharmacology part 2: The spin trap agent disodium-[(tert-butylimino)methyl]benzene-1,3-disulfonate N-oxide (NXY-059) increases hemorrhage incidence in a rabbit large clot embolic stroke model. Combination studies with tissue plasminogen activator (tPA)
10. NXY-059, a free radical trapping agent, substantially lessens the functional disability resulting from cerebral ischemia in a primate species
11. Tolerability and pharmacokinetics of the nitrone NXY-059 in patients with acute stroke
12. Safety and tolerability of NXY-059 at higher target concentrations in acute stroke patients