An alternate targeting pathway for procathepsin L in mouse fibroblasts

Traffic

Volumn 3, Issue 2, 2002, Pages 147-159

  Ahn, Kyujeong ^a   Yeyeodu, Susan ^a   Collette, John ^a   Madden, Victoria ^a   Arthur, Joshua ^a   Li, Lian ^b   Erickson, Ann H ^a  

^a UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^b EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

CD63; Lysosome; Multivesicular endosomes; Procathepsin L; Protease; Secretion; Transformation

Indexed keywords

CATHEPSIN L; CD63 ANTIGEN; CELL RECEPTOR; CYCLOHEXIMIDE; CYSTEINE PROTEINASE; ENZYME PRECURSOR; GROWTH HORMONE; LEUPEPTIN; MANNOSE PHOSPHATE; PEPTIDE ANTIBODY; PHORBOL 13 ACETATE 12 MYRISTATE; PROTEINASE;

ANIMAL CELL; ANTIBODY LABELING; ARTICLE; CELL MEMBRANE; CELL SECRETION; CELL STIMULATION; CELL TRANSFORMATION; CELL ULTRASTRUCTURE; CELLULAR DISTRIBUTION; CONTROLLED STUDY; ENDOSOME; ENZYME ACTIVATION; ENZYME LOCALIZATION; FIBROBLAST; LYSOSOME; MICROSOME; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN SYNTHESIS; PROTEIN TARGETING; SECRETORY GRANULE; SUCROSE GRADIENT;

3T3 CELLS; ANIMALS; ANTIGENS, CD; BLOTTING, WESTERN; CATHEPSINS; CELL LINE, TRANSFORMED; CYSTEINE ENDOPEPTIDASES; ENZYME PRECURSORS; FIBROBLASTS; LYSOSOMES; MICE; MICROSCOPY, ELECTRON; MICROSOMES; PLATELET MEMBRANE GLYCOPROTEINS; RAS PROTEINS; RECEPTOR, IGF TYPE 2; TETRADECANOYLPHORBOL ACETATE; TIME FACTORS; TRANSFECTION;

EID: 0036114243     PISSN: 13989219     EISSN: None     Source Type: Journal    
DOI: 10.1034/j.1600-0854.2002.030207.x     Document Type: Article

References (68)

1. The biogenesis of lysosomes
2. Molecular recognition and targeting of lysosomal proteins
3. Structure and function of the mannose 6-phosphate/insulin-like growth factor II receptors
4. The trans Golgi network: Sorting at the exit site of the Golgi complex
5. Disorders of lysosomal enzyme synthesis and localization: I-cell disease and pseudo-Hurler polydystrophy
6. Synthesis, transport and processing of cathepsin C in Morris hepatoma 7777 cells and rat hepatocytes
7. In vitro mutagenesis of potential N-glycosylation sites of arylsulfatase A
8. Phosphorylation and subcellular location of α-L-fucosidase in lymphoid cells from patients with I-cell disease and pseudo-Hurler polydystrophy
9. Mannose 6-phosphate-independent targeting of lysosomal enzymes in I-cell disease B lymphoblasts
10. Differential sorting of lysosomal enzymes in mannose 6-phosphate receptor-deficient fibroblasts
11. The two mannose 6-phosphate receptors transport distinct complement of lysosomal proteins
12. Alternative mechanisms for trafficking of lysosomal enzymes in mannose 6-phosphate receptor-deficient mice are cell type-specific
13. Cathepsin D is membrane-associated in macrophage endosomes
14. Transient membrane association of the precursors of cathepsin C during their transfer into lysosomes
15. Procathepsins L and D are membrane-bound in acidic microsomal vesicles
16. Mannose 6-phosphate-independent membrane association of cathepsin D, glucocerebrosidase, and sphingolipid-activating protein in HepG2 cells
17. Proteolysis of glucagon within hepatic endosomes by membrane-associated cathepsins B and D
18. Procathepsin L self-association as a mechanism for selective secretion
19. The major excreted protein of transformed fibroblasts is an activable acid-protease
20. Multiple processing of procathepsin L to cathepsin L in vivo
21. Mechanism for selective secretion of a lysosomal protease by transformed mouse fibroblasts
22. Evidence that syntaxin 1A is involved in storage in the secretory pathway
23. A glycophospholipid membrane anchor acts as an apical targeting signal in polarized epithelial cells
24. Reduced temperature prevents transfer of a membrane glycoprotein to the cell surface but does not prevent terminal glycosylation
25. Evidence for colocalization and interaction between 37 and 39 kDa isoforms of a secretory carrier membrane proteins (SCAMPs)
26. Rab8 promotes polarized membrane transport through reorganization of actin and microtubules in fibroblasts
27. Y receptor-mediated induction of CD63 transcripts, a tetraspanin determined to be necessary for differentiation of the intestinal epithelial cell line, hBRIEb 380i cells
28. The tetraspanin CD63/lamp3 cycles between endocytic and secretory compartments in human endothelial cells
29. Cellular distribution of CD63 antigen in platelets and in three megakaryocytic cell lines
30. Distribution of newly synthesized lysosomal enzymes in the endocytic pathway of normal rat kidney cells
31. Analysis of the endocytic system by using horseradish peroxidase
32. Trans-Golgi network (TGN) of different cell types three-dimensional structural characteristics and variability
33. Overexpression of human alphagalactosidase A results in its intracellular aggregation, crystallization in lysosomes, and selective secretion
34. Tumor promoters and Kirsten sarcoma virus increase synthesis of a secreted glycoprotein by regulating levels of translatable mRNA
35. Multivesicular bodies in HEp-2 cells are maturing endosomes
36. Differential targeting and processing of procathepsin D in normal and transformed murine 3T3 fibroblasts
37. Transformation by oncogenic ras-p21 alters the processing and sub-cellular localization of the lysosomal protease cathepsin D
38. Weibel-Palade body membrane proteins exhibit differential trafficking after exocytosis in endothelial cells
39. Selective enrichment of tetraspan proteins on the internal vesicles of multivesicular endosomes and on exosomes secreted by human B-lymphocytes
40. Influence of 12 (S)-hydroxyeicosatetraenoic acid (12 (S)-HETE) on the localization of cathepsin B and cathepsin L in human lung tumor cells
41. On vesicles and membrane compartments
42. Isolation and characterization of early endosomes, late endosomes and terminal lysosomes: Their role in protein degradation
43. Dense core lysosomes can fuse with late endosomes and are re-formed from the resultant hybrid organelles
44. Cathepsin B: Association with plasma membrane in metastatic tumors
45. Membrane-associated cathepsin L. A role in metastasis of melanomas
46. Immunodetection of cathepsins B and L present in and secreted from human pre-malignant and malignant colorectal tumour cell lines
47. Cell surface complex of cathepsin B/annexin II tetramer in malignant progression
48. Constitutive and basal secretion from the endocrine cell line, AtT-20
49. Protein sorting and secretion granule formation in regulated secretory cells
50. Protein traffic from the secretory pathway to the endosomal system in pancreatic β cells
51. A biosynthetic regulated secretory pathway in constitutive secretory cells
52. Cathepsin D in breast cancer cells can digest extracellular matrix in large acidic vesicles
53. Characterization of very acidic phagosomes in breast cancer cells and the association with invasion
54. Rac1-induced endocytosis is associated with intracellular proteolysis during migration through a three-dimensional matrix
55. Secretory granule biogenesis: Rafting to the SNARE
56. Mannose-6-phosphate receptor independend targeting of lysosomal enzymes
57. Intermolecular association of lysosomal protein precursors during biosynthesis
58. fat mice
59. Protein secretion: Puzzling receptors
60. Post-Golgi biosynthetic trafficking
61. Cloning and characterization of a mouse cysteine proteinase
62. Cleavage of structural proteins during the assembly of the head of bacteriophage T4
63. Microwave processing of cell monolayers in situ for post-embedding immunocytochemistry with retention of ultrastructure and antigenicity
64. Ultrastructure of Leydig cells as revealed by secondary tissue treatment with a ferrocyanide: Osmium mixture
65. White resin and improved on-grid immunogold detection of vicilin, a pea storage protein
66. Gold markers for single and double immunolabelling of ultrathin cryosections
67. Biosynthesis and intracellular targeting of the lysosomal aspartic proteinase cathepsin D