Progress and problems in defining susceptibility genes for rheumatic diseases

Rheumatology

Volumn 41, Issue 4, 2002, Pages 361-364

  Lanchbury, J ^a   Hall, M ^a   Steer, S ^a  

^a GUY S HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

APOLIPOPROTEIN E; CORTICOTROPIN RELEASING FACTOR; HLA ANTIGEN; INTERLEUKIN 1BETA; TUMOR NECROSIS FACTOR ALPHA;

CONTROLLED STUDY; EDITORIAL; GENE FREQUENCY; GENE LINKAGE DISEQUILIBRIUM; GENE LOCATION; GENE MAPPING; GENE REPLICATION; GENE SEQUENCE; GENETIC ANALYSIS; GENETIC ASSOCIATION; GENETIC HETEROGENEITY; GENETIC LINKAGE; GENETIC POLYMORPHISM; GENETIC SCREENING; GENETIC SUSCEPTIBILITY; GENETIC VARIABILITY; HEREDITY; HLA SYSTEM; HUMAN; HYPOTHESIS; MARKER GENE; MEDICAL RESEARCH; MICROSATELLITE MARKER; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; RAT; RHEUMATOID ARTHRITIS; SINGLE NUCLEOTIDE POLYMORPHISM; TANDEM REPEAT;

ARTHRITIS, RHEUMATOID; CHROMOSOME MAPPING; GENETIC PREDISPOSITION TO DISEASE; HUMANS;

EID: 0036113837     PISSN: 14620324     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Editorial

References (46)

1. How many diseases does it take to map a gene with SNPs?
2. Linkage disequilibrium mapping of complex disease: Fantasy or reality?
3. Genetic dissection of complex traits
4. The future of genetic epidemiology
5. The major murine systemic lupus erythematosus susceptibility locus, Sle1, is a cluster of functionally related genes
6. Single nucleotide polymorphisms and the future of genetic epidemiology
7. Identification of the gene loci that predispose to rheumatoid arthritis
8. New susceptibility locus for rheumatoid arthritis suggested by a genome-wide linkage study
9. A genomewide screen in multiplex rheumatoid arthritis families suggests genetic overlap with other autoimmune diseases
10. A genome-wide search for susceptibility genes in human systemic lupus erythematosus sib-pair families
11. Genome screening in human systemic lupus erythematosus: Results from a second Minnesota cohort and combined analyses of 187 sib-pair families
12. Genome scan of human systemic lupus erythematosus by regression modeling: Evidence of linkage and epistasis at 4p16-15.2
13. Genome scan of human systemic lupus erythematosus: Evidence for linkage on chromosome 1q in African-American pedigrees
14. Genome-wide screen for systemic lupus erythematosus susceptibility genes in multiplex families
15. A comparison of genome-scans performed in multicase families with systemic lupus erythematosus from different population groups
16. Fine mapping of the SLEB2 locus involved in susceptibility to systemic lupus erythematosus
17. A susceptibility locus for human systemic lupus erythematosus (hSLE1) on chromosome 2q
18. A genome-wide screen for susceptibility loci in ankylosing spondylitis
19. Whole-genome screening in ankylosing spondylitis: Evidence of non-MHC genetic-susceptibility loci
20. Stratification analysis of an osteoarthritis genome screen-suggestive linkage to chromosomes 4, 6 and 16
21. Genome scan for predisposing loci for distal interphalangeal joint osteoarthritis: Evidence for a locus on 2q
22. Linkage analysis of chromosome 2q in osteoarthritis
23. Prevalence of BRCA1 and BRCA2 gene mutations in patients with early-onset breast cancer
24. Genetics of Parkinson's disease
25. Systemic lupus erythematosus, complement deficiency and apoptosis
26. Genetic mapping of susceptibility loci in the genes involved in rheumatoid arthritis
27. A model for disease heterogeneity in systemic lupus erythematosus. Relationships between histocompatibility antigens, autoantibodies, and lymphopenia or renal disease
28. HLA class II restriction of autoantibody production in patients with systemic lupus erythematosus
29. Searching for genes in complex diseases: Lessons from systemic lupus erythematosus
30. Multiple loci for multiple sclerosis
31. Searching for genetic determinants in the new millennium
32. The future of genetic case-control studies
33. Peaks and troughs in linkage disequilibrium mapping for the rheumatic diseases
34. Meta-analysis of genome searches
35. Suggestive evidence for association of human chromosome 18q12-q21 and its orthologue on rat and mouse chromosome 18 with several autoimmune diseases
36. Multipoint linkage analysis of a candidate gene locus in rheumatoid arthritis demonstrates significant evidence of linkage and association with the corticotropin-releasing hormone genomic region
37. A single corticotropin releasing hormone (CRH) genomic region (8q13) haplotype is associated with both familial and sporadic rheumatoid arthritis
38. SNPing away at complex diseases: Analysis of single-nucleotide polymorphisms around APOE in Alzheimer disease
39. A model for susceptibility polymorphisms for complex diseases: Apolipoprotein E and Alzheimer disease
40. Genetic analysis of case/control data using estimated haplotype frequencies: Application to APOE locus variation and Alzheimer's disease
41. Clinical and immunogenetic characteristics of European multicase rheumatoid arthritis families
42. Prospects for whole-genome linkage disequilibrium mapping of common disease genes
43. Genetic epidemiology of single-nucleotide polymorphisms
44. Initial sequencing and analysis of the human genome
45. Assessing the role of HLA-linked and unlinked determinants of disease
46. Interferon gamma gene in rheumatoid arthritis