Linkage disequilibrium and founder effect analysis of the NF1 gene in French Canadians from the Quebec population

Annales de Genetique

Volumn 45, Issue 1, 2002, Pages 39-44

  Fang, Li Juan ^a   Li, Wentian ^b   Chalhoub, Nader ^a   Feingold, Josué ^c   Ortenberg, June ^d   Thirion, Jean Paul ^a  

^a UNIVERSITY OF SHERBROOKE   (Canada)

^b ROCKEFELLER UNIVERSITY   (United States)

^c HÔPITAL NECKER ENFANTS MALADES   (France)

^d MONTREAL CHILDREN S HOSPITAL   (Canada)

Author keywords

Founder effect; French Canadians; Linkage disequilibrium; Microsatellite; Neurofibromatosis type 1 (NF1)

Indexed keywords

GENE PRODUCT; MICROSATELLITE DNA; NEUROFIBROMIN;

ARTICLE; CANADA; CHROMOSOME DELETION; CLINICAL ARTICLE; CORRELATION ANALYSIS; DISEASE MARKER; FOUNDER EFFECT; GENE LINKAGE DISEQUILIBRIUM; GENE MUTATION; GENOTYPE; HUMAN; LINKAGE ANALYSIS; NEUROFIBROMATOSIS; PEDIGREE;

FOUNDER EFFECT; GENE FREQUENCY; GENES, NEUROFIBROMATOSIS 1; GENETIC MARKERS; HAPLOTYPES; HUMANS; LINKAGE DISEQUILIBRIUM; MICROSATELLITE REPEATS; QUEBEC;

EID: 0036111932     PISSN: 00033995     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0003-3995(02)01105-X     Document Type: Article

References (39)

1. Exclusion of allelism of Noonan syndrome and Neurofibromatosis-type 1 in a large family with Noonan syndrome-Neurofibromatosis association
2. Homogénéité ou diversité? L'histoire de la population du Québec revue à travers ses gènes
3. The oculopharyngeal muscular dystrophy locus maps to the region of the cardiac α and β myosin heavy chain genes on chromosome 14q11.2-q13
4. Neurofibromatosis type 1: A model condition for the study of the molecular basis of variable expressivity in human disorders
5. The gene responsible for a severe form of peripheral neuropathy and agenesis of the corpus callosum maps to chromosome 15q
6. The French origins of the Canadian population 1608-1759
7. Founder effect in beta-thalassaemia in Portneuf, Québec
8. Genotype analysis of the NF1 gene in the French Canadian from the Québec population
9. A novel mutation in the Neurofibromatosis type 1 (NF1) gene promotes skipping of two exons by preventing exon definition
10. Neurofibromatosis type 1: Piecing the puzzle together
11. Linkage disequilibrium in the neurofibromatosis 1 (NF1) region: Implications for gene mapping
12. Clouston hidrotic ectodermal dysplasia (HED): Genetic homogeneity, presence of a founder effect in the French Canadians population and fine genetic mapping
13. Parametric and non-parametric linkage analysis: A unified multipoint approach
14. Vitamin D deficiency, rickets, and the founder effect in French Canadianss
15. Two CA/GT repeat polymorphisms in intron 27 of the human neurofibromatosis type 1 (NF1) gene
16. A highly informative CA/GT repeat polymorphism in intron 38 of the human neurofibromatosis type 1 (NF1) gene
17. Genomic organization of the Neurofibromatosis 1 gene (NF1)
18. The trimmed-haplotype test for linkage disequilibrium
19. Lack of independence between five DNA polymorphisms in the NF1 gene
20. Clinical, metabolic, and genetic aspects of cytochrome C oxidase deficiency in Saguenay-Lac-Saint-Jean
21. Genotyping of PCR-based polymorphisms and linkage-disequilibrium analysis at the NF1 locus
22. Cystic fibrosis mutations in French Canadianss: Three CFTR mutations are relatively frequent in a Québec population with an elevated incidence of cystic fibrosis
23. General score tests for association of genetic markers with disease using cases and their parents
24. Molecular genetics of neurofibromatosis type 1 (NF1)
25. Transmission test for linkage disequilibrium: The insulin gene region and insulin-dependent diabetes mellitus (IDDM)
26. Confirmation of linkage of oculopharyngeal muscular dystrophy to chromosome 14q11.2-q13
27. A powerful likelihood method for the analysis of linkage disequilibrium between trait loci one or more polymorphic marker loci
28. Founder BRCA1 and BRCA2 mutations in French Canadians breast and ovarian cancer families
29. Molecular basis of neurofibromatosis type 1 (NF1): Mutation analysis and polymorphisms in the NF1 gene
30. Linkage disequilibrium between four intragenic polymorphic microsatellites of the NF1 gene and its implications for genetic counselling
31. Geographic distribution of French-Canadian low-density lipoprotein receptor gene mutations in the province of Québec
32. Mapping of a gene determining familial partial epilepsy with variable foci to chromosome 22q11-q12