Towards a general model for protein-substrate stereoselectivity

Protein Science

Volumn 11, Issue 6, 2002, Pages 1330-1339

  Sundaresan, Vidyasankar ^a,b   Abro, Ravinder ^a  

^a California Institute of Technology   (United States)

^b SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

Biomolecular recognition; Chiral resolution; Four location model; Isocitrate dehydrogenase; Multiple stereocenters; Rational drug design; Receptor substrate complementarity; Three point attachment model

Indexed keywords

ISOCITRATE DEHYDROGENASE; ISOCITRIC ACID; ALPHA ADRENERGIC RECEPTOR; ISOCITRATE DEHYDROGENASE (NADP+); NORADRENALIN; PROTEIN;

ARTICLE; CHIRALITY; DRUG DESIGN; ENANTIOMER; GEOMETRY; LIGAND BINDING; MOLECULAR MODEL; MOLECULAR RECOGNITION; PRIORITY JOURNAL; PROTEIN INTERACTION; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; RECEPTOR BINDING; STEREOCHEMISTRY; ANIMAL; BINDING SITE; CHEMICAL MODEL; CHEMISTRY; ENZYME SPECIFICITY; HUMAN; METABOLISM; STEREOISOMERISM;

ANIMALS; BINDING SITES; HUMANS; ISOCITRATE DEHYDROGENASE; ISOCITRATES; MODELS, CHEMICAL; NOREPINEPHRINE; PROTEINS; RECEPTORS, ADRENERGIC, ALPHA; STEREOISOMERISM; SUBSTRATE SPECIFICITY;

EID: 0036107851     PISSN: 09618368     EISSN: None     Source Type: Journal    
DOI: 10.1110/ps.3280102     Document Type: Article

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