Synthesis, dimerization, and biological activity of hexaoxygenated chalcones related to calythropsin and combretastatins

Natural Product Letters

Volumn 16, Issue 3, 2002, Pages 187-193

  Magiatis, P ^a   Seguin, E ^b   Elomri, A ^b   Skaltsounis, A L ^a   Rui Chao, L ^c   Tillequin, F ^c  

^a UNIVERSITY OF ATHENS   (Greece)

^b UNIVERSITÉ DE ROUEN   (France)

^c UNIVERSITÉ PARIS DESCARTES   (France)

Author keywords

Aldol condensation; Chalcone; Cyclobutane; Cytotoxicity; Photochemical dimerization; Tubuline assembly

Indexed keywords

1,3 BIS(3,4,5 TRIMETHOXYBENZOYL) 2,4 BIS(3,4,5 TRIMETHOXYPHENYL)CYCLOBUTANE; 3,4,5,3',4',5' HEXAMETHOXYCHALCONE; 4,4' DIACETOXY 3,5,3',5' TETRAMETHOXYCHALCONE; 4,4' DIBENZYLOXY 3,5,3',5' TETRAMETHOXYCHALCONE; 4,4' DIHYDROXY 3,5,3',5' TETRAMETHOXYCHALCONE; 4,4' DIPHENACYLOXY 3,5,3',5' TETRAMETHOXYCHALCONE; CHALCONE DERIVATIVE; DIMER; TUBULIN; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CONCENTRATION (PARAMETERS); CYTOTOXICITY TEST; DEPOLYMERIZATION; DIMERIZATION; DRUG ACTIVITY; DRUG CYTOTOXICITY; DRUG MECHANISM; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IC 50; LEUKEMIA CELL; LEUKEMIA L 1210; MICROTUBULE ASSEMBLY; POLYMERIZATION; PROTEIN ASSEMBLY; PROTEIN SYNTHESIS INHIBITION;

ANIMALS; BRAIN; CHALCONE; DRUG SCREENING ASSAYS, ANTITUMOR; INHIBITORY CONCENTRATION 50; LEUKEMIA; MICE; MOLECULAR STRUCTURE; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PHOTOCHEMISTRY; SPECTROPHOTOMETRY, INFRARED; STRUCTURE-ACTIVITY RELATIONSHIP; SWINE; TUBULIN; TUMOR CELLS, CULTURED;

EID: 0036099762     PISSN: 10575634     EISSN: None     Source Type: Journal    
DOI: 10.1080/10575630290010993     Document Type: Article

References (23)

1. The pharmacology and therapeutic aspects of colchicine