Arthritis-induced increase in serum levels of IGF-binding protein-3 in rats is secondary to the decrease in its proteolytic activity

Journal of Endocrinology

Volumn 173, Issue 2, 2002, Pages 357-364

  Ibanez de Caceres I ^a   Holly, J M P ^a   Priego, T ^a   Martin A I ^a   Lopez Calderon A ^a   Villanua M A ^a  

^a UNIVERSIDAD COMPLUTENSE DE MADRID   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

FREUND ADJUVANT; GROWTH HORMONE; MESSENGER RNA; RECOMBINANT GROWTH HORMONE; SOMATOMEDIN BINDING PROTEIN;

ADJUVANT ARTHRITIS; ARTICLE; CONTROLLED STUDY; DECAPITATION; DRUG EFFECT; GENE EXPRESSION; LIVER; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN DEGRADATION; PROTEIN SYNTHESIS; RAT;

ANIMALS; ARTHRITIS, EXPERIMENTAL; BLOTTING, NORTHERN; GROWTH HORMONE; HUMANS; INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN 3; INSULIN-LIKE GROWTH FACTOR I; LIVER; MALE; RATS; RATS, WISTAR; RNA, MESSENGER;

EID: 0036099095     PISSN: 00220795     EISSN: None     Source Type: Journal    
DOI: 10.1677/joe.0.1730357     Document Type: Article

References (58)

1. Cloning and characterization of the growth hormone-dependent insulin-like growth factor binding protein (IGFBP-3) in the rat
2. Tissue distribution and regulation of insulin-like growth factor (IGF)-binding protein-3 messenger ribonucleic acid (mRNA) in the rat: Comparison with IGF-I mRNA expression
3. Increased proteolysis of insulin-like growth factor-binding protein-3 (IGFBP-3) in noninsulin-dependent diabetes mellitus serum, with elevation of a 29-kilodalton (kDa) glycosylated IGFBP-3 fragment contained in the 130- to 150-kDa ternary complex
4. Radioimmunoassay of growth hormone-dependent insulin-like growth factor binding protein in human plasma
5. Insulin-like growth factor (IGF) and IGF-binding proteins: Comparison of human serum and lymph
6. In vivo proteolysis of serum insulin-like growth factor (IGF) binding protein-3 results in increased availability of IGF to target cells
7. A specific radioimmunoassay for the growth hormone (GH)-dependent somatomedin-binding protein: Its use for diagnosis of GH deficiency
8. The effects of recombinant human IGF-I administration on concentrations of acid labile subunit, IGF binding protein-3, IGF-I, IGF-II and proteolysis of IGF binding protein-3 in adolescents with insulin-dependent diabetes mellitus
9. Potentiation of insulin-like growth factor (IGF) action by IGF-binding protein-3: Studies of underlying mechanism
10. The insulin-like growth factor (IGF)-binding proteins and IGF bioactivity in Laron-type dwarfism
11. The differential regulation of the circulating levels of the insulin-like growth factors and their binding proteins (IGFBP) 1, 2 and 3 after elective abdominal surgery
12. Regulation of serum insulin-like growth factor-I (IGF-I) and IGF binding proteins during rat pregnancy
13. Insulin-like growth factor-binding protein-3 proteolysis is induced after elective surgery
14. Growth hormone-dependent insulin-like growth factor (IGF) binding protein both inhibits and potentiates IGF-I-stimulated DNA synthesis in human skin fibroblasts
15. Growth hormone (GH) stimulates insulin-like growth factor-I (IGF-I) and IGF-I-binding protein-3, but not GH receptor gene expression in livers of juvenile rats
16. Local disruption of the insulin-like growth factor system in the arthritic joint
17. Characterization of insulin-like growth factor binding proteins (IGFBPs) during gestation in mice: Effects of hypophysectomy and an IGFBP-specific serum protease activity
18. Expression of serum insulin-like growth factors, insulin-like growth factor-binding proteins, and the growth hormone-binding protein in heterozygote relatives of Ecuadorian growth hormone receptor deficient patients
19. Differential long-term effects of insulin-like growth factor-I (IGF-I), growth hormone (GH), and IGF-I plus GH on body growth and IGF binding proteins in hypophysectomized rats
20. Proteolytic modification of insulin-like growth factor-binding proteins: Comparison of conditioned media from human cell lines, circulating proteases and characterized enzymes
21. Administration of growth hormone (GH), but not insulin-like growth factor-I (IGF-I) by continuous infusion can induce the formation of the 150-kilodalton IGF-binding protein-3 complex in GH-deficient rats
22. Inflammation-related neutrophil proteases, cathepsin G and elastase, function as insulin-like growth factor binding protein proteases
23. Insulin-like growth factor binding proteins in maternal serum throughout gestation and in the puerperium: Effects of a pregnancy-associated serum protease activity
24. Cellular adhesion molecules in rat adjuvant arthritis
25. Analysis of serum insulin-like growth factor binding protein using Western blotting: Use of the method for titration of the binding proteins and competitive binding studies
26. Evidence of enzymatic degradation of insulin-like growth factor-binding proteins in the 150K complex during pregnancy
27. IGF and IGF-binding proteins in rats with adjuvant-induced arthritis given recombinant human growth hormone
28. Insulin-like growth factor-binding protein-3 protease activity in Snell normal and Pit-1 deficient dwarf mice
29. A simple assay for the proteolysis of insulin-like growth factor binding protein-3 (IGFBP-3)
30. Vitamin D metabolism in rats with adjuvant-induced arthritis
31. Growth hormone resistance
32. Use of the ligand immunofunctional assay for human insulin-like growth factor (IGF) binding protein-3 (IGFBP-3) to analyze IGFBP-3 proteolysis and IGF-I bioavailability in healthy adults, GH-deficient and acromegalic and diabetics
33. Differential regulation of tissue insulin-like growth factor-binding protein (IGFBP)-3, IGF-I and IGF type 1 receptor mRNA levels, and serum IGF-I and IGFBP concentrations by growth hormone and IGF-I
34. Association between insulin-like growth factor status and physical activity levels in rheumatoid arthritis
35. Adjuvant-induced polyarthritis: Synovial cell activation prior to polyarthritis onset
36. Chronic inflammation inhibits GH secretion and alters the serum insulin-like growth factor system in rats
37. The decrease in hepatic IGF-I gene expression in arthritic rats is not associated with modifications in hepatic GH receptor mRNA
38. Insulin-like growth factor binding protein-3: Biochemistry and physiology
39. The effect of epidermal growth factor and IGF-I infusion on hepatic and renal expression of the IGF-system in adult female rats
40. Changes in systemic levels of insulin-like growth factors and their binding proteins in patients with rheumatoid arthritis
41. Elevated levels of insulin-like growth factor (IGF) binding protein-3 in rheumatoid arthritis synovial fluid inhibit stimulation by IGF-I of articular chondrocyte proteoglycan synthesis
42. Hyperprolactinaemia in hypophysectomized or intact male rats and the development of adjuvant arthritis
43. Acute and short-term effects of growth hormone on insulin-like growth factors and their binding proteins: Serum levels and hepatic messenger ribonucleic acid responses in humans
44. Adjuvant arthritis as a model of inflammatory cachexia
45. Growth hormone, but not insulin-like growth factor I, induces a serum protease activity for insulin-like growth factor binding protein-3 in hypophysectomized rats in vivo
46. Synthesis of insulinlike growth factor binding proteins and of the acid-labile subunit in primary cultures of rat hepatocytes, of Kupffer cells, and in cocultures: Regulation by insulin, insulinlike growth factor, and growth hormone
47. Twenty-four-hour rhythms of serum ACTH, prolactin, growth hormone, and thyroid-stimulating hormone, and of median-eminence norepinephrine, dopamine, and serotonin, in rats injected with Freund's adjuvant
48. Differential changes in free and total insulin-like growth factor I after major, elective abdominal surgery: The possible role of insulin-like growth factor-binding protein-3 proteolysis
49. No effect of growth hormone on serum insulin-like growth factor binding protein-3 proteolysis
50. Effects of endotoxin lipopolysaccharide administration on the somatotropic axis
51. Low serum levels of free and total insulin-like growth factor I (IGF-I) in patients with anorexia nervosa are not associated with increased IGF-binding protein-3 proteolysis
52. Temporal expression of inflammatory cytokines and chemokines in rat adjuvant-induced arthritis
53. IGF and IGF-binding protein system in the synovial fluid of osteoarthritic and rheumatoid arthritic patients
54. Hormonal and metabolic effects and pharmacokinetics of recombinant insulin-like growth factor-I in growth hormone receptor deficiency/Laron syndrome
55. Coculture of primary rat hepatocytes and nonparenchymal cells permits expression of insulin-like growth factor binding protein-3 in vitro
56. Alterations in insulin-like growth factor binding protein-3 proteolysis and complex formation in the arthritic joint
57. Animal models of rheumatoid arthritis
58. Absence of proteolysis of insulin-like growth factor binding protein-3 in serum from patients with growth hormone deficiency