Cardiac contractile function is enhanced in isolated ventricular myocytes from growth hormone transgenic mice

Journal of Endocrinology

Volumn 173, Issue 2, 2002, Pages 257-264

  Colligan, P B ^a   Brown Borg, H M ^a   Duan, J ^a   Ren, B H ^a   Ren, J ^a  

^a UNIVERSITY OF NORTH DAKOTA SCHOOL OF MEDICINE AND HEALTH SCIENCES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM ION; FURA 2; GROWTH HORMONE;

ACROMEGALY; AGE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CALCIUM CELL LEVEL; CARDIOMEGALY; CELL ISOLATION; CELL SIZE; CONTROLLED STUDY; ECHOCARDIOGRAPHY; EXCITATION CONTRACTION COUPLING; EXTRACELLULAR CALCIUM; HEART CONTRACTION; HEART DEVELOPMENT; HEART DISEASE; HEART FUNCTION; HEART MUSCLE CELL; HEART MUSCLE CONTRACTILITY; HEART VENTRICLE; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; TRANSGENIC MOUSE; WEIGHT GAIN; WILD TYPE;

ANIMALS; CALCIUM; CELL SIZE; CELLS, CULTURED; GENE EXPRESSION; GROWTH HORMONE; HEART VENTRICLES; MALE; MICE; MICE, TRANSGENIC; MICROSCOPY, FLUORESCENCE; MYOCARDIAL CONTRACTION; MYOCARDIUM; STIMULATION, CHEMICAL;

EID: 0036098869     PISSN: 00220795     EISSN: None     Source Type: Journal    
DOI: 10.1677/joe.0.1730257     Document Type: Article

References (30)

1. Body composition, bone metabolism, heart structure and function in growth hormone deficient adults before and after growth hormone replacement therapy at low doses
2. Overexpression of bovine growth hormone in transgenic mice is associated with changes in hepatic insulin receptors and in their kinase activity
3. Vascular function and blood pressure in GH transgenic mice
4. Impairment of cardiac function and bioenergetics in adult transgenic mice overexpressing the bovine growth hormone gene
5. Growth hormone attenuates early left ventricular remodeling and improves cardiac function in rats with large myocardial infarction
6. Growth hormone and the heart
7. Role of hyperinsulinemia on hepatic insulin binding and insulin receptor autophosphorylation in the presence of high growth hormone (GH) levels in transgenic mice expressing GH gene
8. Impaired cardiac performance is a distinct feature of uncomplicated acromegaly
9. A preliminary study of growth hormone in the treatment of dilated cardiomyopathy
10. Cardiovascular effects of short-term growth hormone hypersecretion
11. The role of the GH/IGF-I axis for cardiac function and structure
12. Transgenic models of growth hormone action
13. Pathology of the heart in acromegaly: Anatomic findings in 27 autopsied patients
14. Cardiovascular aspects in acromegaly: Effects of treatment
15. Cardiological aspects of growth hormone and insulin-like growth factor-I
16. Growth hormone and cardiac function
17. Tissue-specific expression and dietary regulation of a chimeric phosphoenolpyruvate carboxykinase/bovine growth hormone gene in transgenic mice
18. Mechanical properties of rat cardiac skinned fibers are altered by chronic growth hormone hypersecretion
19. Cardiac structural and functional abnormalities in GH-deficient adults
20. Effect of excessive secretion of growth hormone on tissues of the rat, with particular reference to the heart and skeletal muscle
21. Altered cardiac contractile responsiveness to insulin-like growth factor I in ventricular myocytes from BB spontaneous diabetic rats
22. Insulin-like growth factor I as a cardiac hormone: Physiological and pathophysiological implications in heart disease
23. Growth hormone, cardiomyocyte contractile reserve, and heart failure
24. Growth hormone and the heart
25. Disproportional bone growth and reduced weight gain in gonadectomized male bovine growth hormone transgenic and normal mice
26. GH replacement fails to improve ventricular function in hypophysectomized rats with myocardial infarction
27. Effects of chronic exposure to bovine growth hormone (bGH) on the hypothalamic-pituitary axis in transgenic mice: Relationship to the degree of expression of the PEPCK.bGH hybrid gene
28. Treatment with growth hormone enhances contractile reserve and intracellular calcium transients in myocytes from rats with postinfarction heart failure
29. Effects of growth hormone and IGF-I on cardiac hypertrophy and gene expression in mice
30. The growth hormone secretagogue hexarelin improves cardiac function in rats after experimental myocardial infarction