Kinetics of paraquat and copper reactions with nitroxides: The effects of nitroxides on the aerobic and anoxic toxicity of paraquat

Chemical Research in Toxicology

Volumn 15, Issue 5, 2002, Pages 686-691

  Goldstein, Sara ^a   Samuni, Amram ^a   Aronovitch, Yaacov ^a   Godinger, Dina ^a   Russo, Angelo ^b   Mitchell, James B ^b  

^a HEBREW UNIVERSITY OF JERUSALEM   (Israel)

^b NATIONAL CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COPPER; METAL DERIVATIVE; NITROXIDE; PARAQUAT; SCAVENGER; XENOBIOTIC AGENT;

AEROBIC METABOLISM; ANIMAL CELL; ANTIOXIDANT ACTIVITY; ARTICLE; CELL MEMBRANE PERMEABILITY; CONTROLLED STUDY; CORRELATION ANALYSIS; KINETICS; MAMMAL CELL; NONHUMAN; OXIDATIVE STRESS; RADIOLYSIS; REACTION ANALYSIS;

ANIMALS; ANOXIA; CELLS, CULTURED; COPPER; CRICETINAE; CRICETULUS; DNA; DRUG INTERACTIONS; ESCHERICHIA COLI; HERBICIDES; KINETICS; NITROGEN OXIDES; PARAQUAT; PULSE RADIOLYSIS;

ANIMALIA; BACTERIA (MICROORGANISMS); MAMMALIA;

EID: 0036098201     PISSN: 0893228X     EISSN: None     Source Type: Journal    
DOI: 10.1021/tx0155956     Document Type: Article

References (24)

1. Microsomal interactions between iron, paraquat, and menadione: Effect on hydroxyl radical production and alcohol oxidation
2. Bacteria form intracellular free radicals in response to paraquat and streptonigrin. Demonstration of the potency of hydroxyl radical
3. Superoxide mediates the toxicity of paraquat for Chinese hamster ovary cells
4. Thioureas react with superoxide radicals to yield a sulfhydryl compound. Explanation for protective effect against paraquat
5. Effects of pH, glucose, and chelating agents on lethality of paraquat to Escherichia coli
6. Electron spin resonance spin-trapping investigation into the effects of paraquat and desferrioxamine on hydroxyl radical generation during acute iron poisoning
7. Zinc protects Escherichia coli against copper-mediated paraquat-induced damage
8. Protection of a rat tracheal epithelial cell line from paraquat toxicity by inhibition of glucose-6-phosphate dehydrogenase
9. Mechanisms of hypoxic and aerobic cytotoxicity of mitomycin C in Chinese hamster V79 cells
10. A novel metal-free low molecular weight superoxide dismutase mimic
11. Oxoammonium cation intermediate in the nitroxide-catalyzed dismutation of superoxide
12. .- or as SOD mimics?
13. Biologically active metal-independent superoxide dismutase mimics
14. Nitroxide stable radicals protect beating cardiomyocytes against oxidative damage
15. Nitroxides block DNA scission and protect cells from oxidative damage
16. Kinetics of nitroxides reaction with iron(II)
17. Mechanisms of the reactions of some copper complexes in the presence of DNA with superoxide, hydrogen peroxide and molecular oxygen
18. Paraquat toxicity: Proposed mechanism of action involving lipid peroxidation
19. Three models of free radical-induced cell injury
20. Copper toxicity: Evidence for the conversion of cupric to cuprous copper in vivo under anaerobic conditions
21. Copper as a hypoxic cell sensitizer of mammalian cells
22. In vivo evidence of hydroxyl radical formation after acute copper and ascorbic acid intake: Electron spin resonance spin trapping investigation
23. Radiosensitization by copper ions and consequent reversal of the oxygen effect
24. Effects of paraquat on Escherichia coli: Differences between B and K-12 strains