Evolution of bacteriophage in continuous culture: A model system to test antiviral gene therapies for the emergence of phage escape mutants

Journal of Virology

Volumn 76, Issue 11, 2002, Pages 5784-5792

  Lindemann, Björn F ^a   Klug, Christian ^a   Schwienhorst, Andreas ^a  

^a Inst fuer Mikrobiologie und Genetik   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIVIRUS AGENT; REPRESSOR PROTEIN;

ARTICLE; BACTERIOPHAGE; BINDING SITE; ESCHERICHIA COLI; NONHUMAN; PRIORITY JOURNAL; SEQUENCE ANALYSIS; VIRAL GENE THERAPY; VIRUS GENOME; VIRUS MUTANT;

ALLOLEVIVIRUS; CAPSID; EVOLUTION, MOLECULAR; GENE EXPRESSION; GENE THERAPY; GENETIC VECTORS; MUTAGENESIS; PLASMIDS; RNA, VIRAL; SEQUENCE ANALYSIS, RNA;

EID: 0036097684     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/JVI.76.11.5784-5792.2002     Document Type: Article

References (54)

1. Prediction of RNA secondary structure, including pseudoknotting, by computer simulation
2. cis-acting elements within an RNA coliphage genome: Fold as you please, but fold you must
3. A polarity, gradient in the expression of the replicase gene of RNA bacteriophage Qβ
4. Evolution im laboratorium
5. RNA sequencing using fluorescent-labeled dideoxynucleotides and automated fluorescence detection
6. Down modulation of HIV-1 gene expression using a prokaryotic RNA-binding protein
7. Regulation of ribosomal RNA promoters with a synthetic lac operator
8. Sequence-specific interaction of R17 coat protein with its ribonucleic acid binding site
9. The quasispecies (extremely heterogeneous) nature of viral RNA genome populations: Biological relevance - A review
10. Translational regulation of ribosomal proteins in Escherichia coli: Molecular mechanisms
11. Self-organization of matter and the evolution of biological macromolecules
12. Sequence space and quasispecies distribution
13. Activation of the translational suppressor 4E-BP1 following infection with encephalomyocarditis virus and poliovirus
14. Direct physical evidence for secondary structure in an isolated fragment of R17 bacteriophage mRNA
15. Translational control of transcription termination in prokaryotes
16. Translational control and the RNA-dependent protein kinase (PKR): Antagonists of PKR enhance the translational activity of mRNAs that include a 161 nucleotide region from reovirus S1 mRNA
17. The readthrough protein A1 is essential for the formation of viable Qβ particles
18. Coevolution of Escherichia coli and bacteriophages in chemostat culture
19. Selection and evolution of bacteriophages in cellstat
20. Continuous culture of bacteriophage Qβ using a cellstat with a bubble wall-growth scraper
21. Cellstat - A continuous culture system of a bacteriophage for the study of the mutation rate and the selection process at the DNA level
22. Structural plasticity in RNA and its role in the regulation of protein translation in coliphage Qβ
23. Translational repression of a viral messenger RNA by a host protein
24. Possible mechanism for transition of viral RNA from polysome to replication complex
25. Whole-virus vaccine development by continuous culture on a complementing host
26. Recombinant RNA phage Qβ capsid particles synthesized and self-assembled in Escherichia coli
27. Cleavage of structural proteins during the assembly of the head of bacteriophage T4
28. Mutants of the bacteriophage f2
29. Mutations of bacteria from virus sensitivity to virus resistance
30. Translational repression: Biological activity of plasmid-endoded bacteriophage T4 RegA protein
31. Oligoribonucleotide synthesis using T7 RNA polymerase and synthetic DNA templates
32. Qβ replicase: Mapping the functional domains of an RNA-dependent RNA polymerase
33. Translational repression by bacteriophage MS2 coat protein expressed from a plasmid. A system for genetic analysis of a protein-RNA interaction
34. Inhibition of protein synthesis by the human immunodeficiency virus type 1 nef gene product
35. RNA binding site of R17 coat protein
36. Constraints on the assembly of spherical virus particles
37. A novel vector for generating RNAs with defined 3′ ends and its use in antiviral strategies
38. Growth kinetics of a bacteriophage in continuous culture
39. The 3′-terminal sequence of Escherichia coli 16S ribosomal RNA: Complementarity to nonsense triplets and ribosome binding sites
40. A two-dimensional model at the nucleotide level for the central hairpin of coliphage Qβ RNA
41. gag
42. Escherichia coli threonyltransfer RNA synthetasc as a model system to study translational autoregulation in prokaryotes
43. Regulation of translation by specific protein/mRNA interactions
44. Translational regulation in bacteriophages
45. An APL-programmed genetic algorithm for the prediction of RNA secondary structure
46. Selection of predation-resistant bacteria in continuous culture
47. The binding site for coat protein on bacteriophage Qβ RNA
48. Molecular basis for repressor activity of Q replicase
49. Proteins of the RNA phages
50. Specific RNA binding by Qβ coat protein
51. Improved M13 phage cloning vectors and host strains: Nucleotide sequences of the M13mp18 and pUC19 vectors