Par-1 regulates stability of the posterior determinant Oskar by phosphorylation

Nature Cell Biology

Volumn 4, Issue 5, 2002, Pages 337-342

  Riechmann, Veit ^a   Gutierrez, Gustavo J ^a   Filardo, Paolo ^a   Nebreda, Angel R ^a   Ephrussi, Anne ^a  

^a EUROPEAN MOLECULAR BIOLOGY LABORATORY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

PHOSPHOPROTEIN; PROTEIN OSK; PROTEINASE ACTIVATED RECEPTOR 1; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BIOACCUMULATION; CELL FREE SYSTEM; CONTROLLED STUDY; DROSOPHILA; EMBRYO; EMBRYO PATTERN FORMATION; GENETIC ANALYSIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; PROTEIN STABILITY; REGULATORY MECHANISM;

3' UNTRANSLATED REGIONS; ANIMALS; BODY PATTERNING; CAENORHABDITIS ELEGANS; CAENORHABDITIS ELEGANS PROTEINS; CYSTEINE ENDOPEPTIDASES; DROSOPHILA MELANOGASTER; DROSOPHILA PROTEINS; EMBRYO; FEMALE; MODELS, BIOLOGICAL; MULTIENZYME COMPLEXES; OVARY; PHOSPHORYLATION; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEIN-SERINE-THREONINE KINASES; RECOMBINANT FUSION PROTEINS; TISSUE EXTRACTS; UBIQUITIN; XENOPUS LAEVIS;

ANIMALIA; ARACHNIDA; CAENORHABDITIS; CAENORHABDITIS ELEGANS; DROSOPHILA MELANOGASTER; HEXAPODA; MELANOGASTER;

EID: 0036094925     PISSN: 14657392     EISSN: None     Source Type: Journal    
DOI: 10.1038/ncb782     Document Type: Article

References (28)

1. Par-1, a gene required for establishing polarity in C. elegans embryos, encodes a putative Ser/Thr kinase that is asymmetrically distributed
2. The Drosophila homolog of C. elegans PAR-1 organizes the oocyte cytoskeleton and directs oskar mRNA localization to the posterior pole
3. A Drosophila melanogaster homologue of Caenorhabditis elegans par-1 acts at an early step in embryonic-axis formation
4. Drosophila par-1 is required for oocyte differentiation and microtubule organization
5. Par-1 is required for the maintenance of oocyte fate in Drosophila
6. MARK, a novel family of protein kinases that phosphorylate microtubule-associated proteins and trigger microtubule disruption
7. Translational control of oskar generates short OSK, the isoform that induces pole plasma assembly
8. Localization of oskar RNA regulates oskar translation and requires Oskar protein
9. Translational regulation of oskar mRNA by Bruno, an ovarian RNA-binding protein, is essential
10. Translational repressor Bruno plays multiple roles in development and is widely conserved
11. Localization-dependent translation requires a functional interaction between the 5′ and 3′ ends of oskar mRNA
12. Induction of germ cell formation by oskar
13. Overexpression of oskar directs ectopic activation of nanos and presumptive pole cell formation in Drosophila embryos
14. Oskar organizes the germ plasm and directs localization of the posterior determinant nanos
15. Oskar mRNA is localized to the posterior pole of the Drosophila oocyte
16. Localization of vasa, a component of Drosophila polar granules, in maternal-effect mutants that alter embryonic anteroposterior polarity
17. Posterior localization of Vasa protein correlates with, but is not sufficient for, pole cell development
18. Oskar protein interaction with Vasa represents an essential step in polar granule assembly
19. Efficient translation and phosphorylation of Oskar require Oskar protein and the RNA helicase Vasa
20. A conserved double-stranded RNA-binding domain
21. RNA sorting in Drosophila oocytes and embryos
22. Stress-activated kinases regulate protein stability
23. Staufen, a gene required to localize maternal RNAs in the Drosophila egg
24. PARsing embryonic polarity
25. PAR-2 is asymmetrically distributed and promotes association of P granules and PAR-1 with the cortex in C. elegans embryos
26. The maternal par genes and the segregation of cell fate specification activities in early Caenorhabditis elegans embryos
27. Gal4 in the Drosophila female germline
28. Cyclin synthesis drives the early embryonic cell cycle