Gastrin biosynthesis in canine G cells

American Journal of Physiology - Gastrointestinal and Liver Physiology

Volumn 282, Issue 5 45-5, 2002, Pages

  Stepan, Vinzenz ^a   Sugano, Kentaro ^a   Yamada, Tadataka ^b   Park, Jung ^a   Dickinson, Chris J ^a,c  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^b GLAXOSMITHKLINE   (United States)

^c A520 MSRB I ^*  (United States)

Author keywords

COOH terminally amidated gastrin; Glycine; Peptidyl glycine amidating monooxygenase; Prohormone convertase

Indexed keywords

ALPHA AMIDATING ENZYME; ASCORBIC ACID; FURIN; GASTRIN; GLYCINE; PROGASTRIN;

ANIMAL CELL; ARTICLE; CELL LINE; CONTROLLED STUDY; DOG; GASTRIN CELL; ISOTOPE LABELING; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN PROCESSING; PROTEIN SYNTHESIS;

EID: 0036088378     PISSN: 01931857     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpgi.00167.2001     Document Type: Article

References (41)

1. Antisense oligonucleotides as a tool for gene functionalization and target validation
2. Complete tyrosine-O-sulphation of gastrin in neonatal rat pancreas
3. Biosynthesis of tyrosine O-sulfated gastrins in rat antral mucosa
4. Molecular forms of gastrin in peptic ulcer: Comparison of serum and tissue concentrations of G17 and G34 in gastric and duodenal ulcer subjects
5. Biosynthesis of somatostatin in canine fundic D cells
6. Heterologous expression of gastrin in murine thyroid carcinoma cells
7. Progastrin and its glycine-extended post-translational processing intermediates in human gastrointestinal tissues
8. Molecular analysis of dibasic endoproteolytic cleavage signals
9. Substrate specificity of the gastrin amidating enzyme
10. Inhibition of the α-amidation of gastrin: Effects on gastric acid secretion
11. Specificity of prohormone convertase endoproteolysis of progastrin in AtT-20 cells
12. Biosynthetic relationships of big and little gastrins
13. Selective loss of α-melanotropin activity in primary cultures of rat intermediate pituitary cells
14. Identification in pituitary tissue of a peptide α-amidation activity that acts on glycine-extended peptides and requires molecular oxygen, copper, and ascorbic acid
15. Influence of ascorbic acid on in vivo amidation of α-melanocyte stimulating hormone in guinea pig pituitary
16. Bombesin stimulation of gastrin release from canine gastrin cells in primary culture
17. The characterization of the ascorbic acid-mediated α-amidation of α-melanotropin in cultured intermediate pituitary lobe cells
18. Impaired α-carboxyamidation of gastrin in vitamin C-deficient guinea
19. Post-translational processing of gastrin in neoplastic human colonic tissues
20. Overexpression of glycine-extended gastrin in transgenic mice results in increased colonic proliferation
21. Culture of Zollinger-Ellison tumor cells
22. cDNA structure of the mouse and rat subtilisin/kexin-like PC5: A candidate proprotein convertase expressed in endocrine and nonendocrine cells
23. Identification and expression of prohormone-converting enzymes in the rat stomach
24. Glycine-extended post-translational processing intermediates of gastrin and cholecystokinin in the gut
25. Human placental sodium-dependent vitamin C transporter (SVCT2): Molecular cloning and transport function
26. "Big gastrins" in the Zollinger-Ellison syndrome
27. Diminished prohormone convertase 3 (PC1/PC3) inhibits progastrin post-translational processing
28. Proprotein convertases (PC1/PC3 and PC2) in normal and neoplastic tissues: Their use as markers of neuroendocrine differentiation
29. cDNA sequence of two distinct pituitary proteins homologous to Kex2 and furin gene products: Tissue-specific mRNAs encoding candidates for pro-hormone processing proteinases
30. Growth promoting effects of glycine-extended progastrin
31. Biosynthesis of the prohormone convertase PC2 in Chinese hamster ovary cells and in rat insulinoma cells
32. Identification of a cDNA encoding a second putative prohormone convertase related to PC2 in AtT20 cells and islets of Langerhans
33. Identification of a human insulinoma cDNA encoding a novel mammalian protein structurally related to the yeast dibasic processing protease Kex2
34. Identification and characterization of glycine-extended post-translational processing intermediates of progastrin in porcine stomach
35. Glycine-extended progastrin processing intermediates: Accumulation and cosecretion with gastrin
36. Stimulation of gastrin release by bombesin and canine gastrin-releasing peptides. Studies with isolated canine G cells in primary culture
37. Progastrin-like immunoreactivity in porcine antrum: Identification and characterization with regionspecific antisera
38. Gastrin and glycine-extended processing intermediates induce different programs of early gene activation
39. Gastrin biosynthesis in the antrum of patients with pernicious anemia
40. Pathways of processing of the gastrin precursor in rat antral mucosa
41. +-dependent vitamin C transporter 1 (hSVCT1): Primary structure, functional characteristics and evidence for a non-functional splice variant